全文获取类型
收费全文 | 1839篇 |
免费 | 132篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 57篇 |
妇产科学 | 43篇 |
基础医学 | 287篇 |
口腔科学 | 9篇 |
临床医学 | 208篇 |
内科学 | 384篇 |
皮肤病学 | 21篇 |
神经病学 | 165篇 |
特种医学 | 36篇 |
外科学 | 159篇 |
综合类 | 13篇 |
一般理论 | 5篇 |
预防医学 | 273篇 |
眼科学 | 14篇 |
药学 | 106篇 |
中国医学 | 6篇 |
肿瘤学 | 183篇 |
出版年
2024年 | 3篇 |
2023年 | 14篇 |
2022年 | 13篇 |
2021年 | 38篇 |
2020年 | 17篇 |
2019年 | 32篇 |
2018年 | 43篇 |
2017年 | 26篇 |
2016年 | 50篇 |
2015年 | 56篇 |
2014年 | 57篇 |
2013年 | 106篇 |
2012年 | 135篇 |
2011年 | 143篇 |
2010年 | 76篇 |
2009年 | 74篇 |
2008年 | 122篇 |
2007年 | 129篇 |
2006年 | 106篇 |
2005年 | 113篇 |
2004年 | 136篇 |
2003年 | 104篇 |
2002年 | 95篇 |
2001年 | 30篇 |
2000年 | 24篇 |
1999年 | 22篇 |
1998年 | 18篇 |
1997年 | 14篇 |
1996年 | 19篇 |
1995年 | 8篇 |
1994年 | 8篇 |
1993年 | 13篇 |
1992年 | 12篇 |
1991年 | 10篇 |
1990年 | 15篇 |
1989年 | 14篇 |
1988年 | 8篇 |
1987年 | 8篇 |
1986年 | 13篇 |
1985年 | 6篇 |
1984年 | 3篇 |
1983年 | 3篇 |
1982年 | 6篇 |
1981年 | 4篇 |
1980年 | 3篇 |
1979年 | 5篇 |
1978年 | 3篇 |
1976年 | 2篇 |
1969年 | 3篇 |
1968年 | 2篇 |
排序方式: 共有1977条查询结果,搜索用时 31 毫秒
71.
Joyce M.G. Florisson Irene M.J. Mathijssen Belinda Dumee Jeannette A.M. Hoogeboom Pino J. Poddighe Ben A. Oostra Jean Pierre Frijns Linda Koster Annelies de Klein Bert Eussen Bert B.A. de Vries Sigrid Swagemakers Peter J. van der Spek Annemieke J.M.H. Verkerk PhD 《American journal of medical genetics. Part A》2013,161(2):244-253
In a screening project of patients with (complex) craniosynostosis using genomic arrays, we identified two patients with craniosynostosis and microcephaly with a deletion in the 2p15p16.1 chromosomal region. This region has been associated with a new microdeletion syndrome, for which patients have various features in common, including microcephaly and intellectual disability. Deletions were identified using Affymetrix 250K SNP array and further characterized by fluorescence in situ hybridization (FISH) analysis and qPCR. The deletions in our two patients overlapped within the 2p15p16.1 microdeletion syndrome area and were 6.8 and 6.9 Mb in size, respectively. FISH and qPCR confirmed the presence of only one copy in this region. Finemapping of the breakpoints indicated precise borders in our patients and were further finemapped in two other previously reported patients. Clinical features of patients with deletions in the 2p15p16.1 region vary. Including data from our patients, now eight out of nine reported patients have microcephaly, one of the major features, and all had intellectual disability. The current reported two patients add different forms of craniosynostosis to the clinical spectrum of this recently recognized microdeletion syndrome. © 2013 Wiley Periodicals, Inc. 相似文献
72.
Füst Ágnes Tóth Jeannette Imre László Nagy Zoltán Zsolt 《International ophthalmology》2021,41(5):1827-1834
International Ophthalmology - To observe and describe the anterior segment optical coherence tomography features of limbally localised non-malignant epithelial mass lesions Thirteen patients (age:... 相似文献
73.
Jeannette M. van der Stelt Ton G. Wempe Louis C. W. Pols 《Clinical linguistics & phonetics》2013,27(10-11):835-844
The influence of the mother tongue on vowel productions in infancy is different for deaf and hearing babies. Audio material of five hearing and five deaf infants acquiring Dutch was collected monthly from month 5–18, and at 24 months. Fifty unlabelled utterances were digitized for each recording. This study focused on developmental paths in vowel productions. The applied automated band filtering analysis is F0‐independent and results in a spectral envelope, sampled in a 40‐dimensional space. Via a Principal Component Analysis (PCA, data reduction), a vowel space for normally hearing 2‐year‐olds was constructed, enabling the projection of the individual developmental data of the infants in a two‐dimensional reference plane. Comparison of the results for the hearing and the deaf infants over 2 years indicates individual as well as group differences. The amount of hearing loss as well as the communication styles seem to be important factors in explaining differences between the infant categories. 相似文献
74.
Incidence and Characteristics of Atypical Femoral Fractures: Clinical and Geometrical Data 下载免费PDF全文
Zeineb Mahjoub Sonia Jean Jean‐Thomas Leclerc Jacques P Brown Dominic Boulet Stéphane Pelet Charlotte Grondin Jeannette Dumont Étienne L Belzile Laetitia Michou 《Journal of bone and mineral research》2016,31(4):767-776
Despite the multitude of studies published on atypical femoral fractures (AFFs), a profile for patients at risk does not exist. This study aimed first at estimating AFF incidence over a 19‐month‐period in Quebec City using the ASBMR Task force criteria to define AFF. The medical records of patients hospitalized for hip or femoral fracture between June 1, 2009, and December 31, 2010, were reviewed. Thirty‐six cases of atypical fractures were identified during the 19‐month period, representing an AFF incidence of 7.0 (range, 4.7 to 9.3) cases per 100,000 person‐years. In the second part of the study, data regarding the characteristics suspected of increasing the risks of AFF were collected from medical and pharmacological records, proximal femur radiographs, and patient interviews. The data regarding each patient with an AFF during years 2008‐2011 were compared to two controls with a hip or femoral fragility fracture or a traumatic fracture, paired for age and sex. Twenty patients with AFF were added to the 36 patients with AFF selected in the first part, thereby 56 patients with AFF were investigated. The association between the occurrence of AFF and bisphosphonates (BPs) use was proven statistically significant in multivariate analysis, odds ratio (OR) = 10.39 (95% CI, 2.22 to 48.58; p = 0.0029). Compared to controls, patients with AFF had excessive femoral offset (43.1 mm versus 38.3 mm, p = 0.0007), proximal femoral neck angle in varus (128.9 degrees versus 134.0 degrees, p < 0.0001), and had greater proximal cortical thickness. This retrospective study confirms the low incidence of AFF, confirms its significant association with exposure to BPs, and reveals the possible contribution of proximal femoral geometry in AFF occurrence. © 2016 American Society for Bone and Mineral Research. 相似文献
75.
Applied electric fields (static and pulsing) are widely used in orthopedic practices to treat nonunions and spine fusions and have been shown to improve ligament healing in vivo. Few studies, however, have addressed the effect of electric fields (EFs) on ligament fibroblast migration and biosynthesis. In the current study, we applied static and pulsing direct current (DC) EFs to calf anterior cruciate ligament (ACL) fibroblasts. ACL fibroblasts demonstrated enhanced migration speed and perpendicular alignment to the applied EFs. The motility of ligament fibroblasts was further modulated on type I collagen. In addition, type I collagen expression increased in ACL fibroblasts after exposure to pulsing EFs. In vitro wound-healing studies showed inhibitory effects of static EFs, which were alleviated with a pulsing EF. Our results demonstrate that applied EFs augment ACL fibroblast migration and biosynthesis and provide potential mechanisms by which EFs may be used for enhancing ligament healing and repair. 相似文献
76.
Hanna van Waart Johanna M. van Dongen Wim H. van Harten Martijn M. Stuiver Rosalie Huijsmans Jeannette A. J. H. Hellendoorn-van Vreeswijk Gabe S. Sonke Neil K. Aaronson 《The European journal of health economics》2018,19(6):893-904
Introduction
A home-based, low-intensity physical activity program (Onco-Move) and a supervised, moderate-to-high intensity, combined resistance and aerobic exercise program (OnTrack) have proven to be effective in maintaining physical fitness and reducing fatigue among breast cancer patients undergoing adjuvant chemotherapy. This study evaluated the cost–utility and cost-effectiveness of Onco-Move and OnTrack.Methods
A total of 230 patients were randomized to Onco-Move, OnTrack, or usual care (UC). Health outcomes included quality-adjusted life years (QALYs), general and physical fatigue, and physical fitness measured at baseline, end of chemotherapy, and 6-month follow-up. Societal costs included professional and informal health care, work absenteeism, and unpaid productivity costs. Cost data were based on 3-monthly questionnaires, supplemented by medication data obtained from pharmacies.Results
Onco-Move is not likely to be cost-effective due to the relatively high willingness-to-pay necessary to reach reasonable probabilities of cost-effectiveness (QALY, general and physical fatigue). Incremental cost-effectiveness ratios for OnTrack compared to UC were €26,916/QALY, €788/1-point decrease in general fatigue and €1402/1-point decrease in physical fatigue. The probability of OnTrack being cost-effective ranged from 31% at a willingness-to-pay (WTP) of €0–79% at a WTP of €80,000/QALY, 97% at a WTP of €15,000/1-point decrease in general fatigue, and 86% at a WTP of €24,000/1-point decrease in physical fatigue. Both interventions had a low probability of being cost-effective for physical fitness. The probability of cost-effectiveness for both interventions was greater among compliant participants.Conclusions
Onco-Move is not likely to be cost-effective. Depending on the decision-makers’ willingness-to-pay, OnTrack could be considered cost-effective in comparison with UC. Trial registration Clinical trial registration number of the Netherlands Trial Register—NTR2159.77.
Jeannette M. Iskander Heather M. Rakestraw Adam T. Morris Beth G. Wildman John C. Duby 《Children's Health Care》2018,47(4):452-466
Objective: Given the associations between externalizing behaviors and childhood unintentional injuries (CUI), this pilot study evaluated whether an empirically supported behavioral parent training program, Group Triple P, decreased risk for CUI.
Methods: Parents of 19 children ages 2–8 referred by their child’s primary care physician for child externalizing behavior problems completed measures of child injury risk pre- and post-Triple P.
Results: Child injury risk and disruptive behavior problems decreased significantly.
Conclusions: Overall, our findings indicate that teaching behavior management and parenting skills to parents has the potential to decrease injury risk in their children, despite this not being an explicit target of intervention. 相似文献
78.
79.
80.
Lucijan Skubic Lea Honjak Jeannette P. Staheli Michael R. Dyen Rebecca M. Ducore Lois M. A. Colgin Anne D. Lewis Mario Poljak 《Viruses》2021,13(4)
Papillomaviruses (PVs) are a diverse group of host species-specific DNA viruses, etiologically linked with various benign and malignant neoplasms of cutaneous and mucosal epithelia. Here, we describe the detection and characterization of the first two PVs naturally infecting Japanese macaques (Macaca fuscata), including the determination of their etiological association(s) with the development of original neoplasms. The molecular and phylogenetic analyses were performed on complete genome sequences of Macaca fuscata PV types 1 (MfuPV1) and 2 (MfuPV2), which were completely sequenced in samples of a malignant oral tumor and benign anogenital neoplasm of Japanese macaques, respectively. Subsequently, two type-specific quantitative real-time PCRs were developed to estimate viral loads of MfuPV1 and MfuPV2 and to evaluate their etiological roles. The in silico molecular analyses revealed that both viral genomes encode characteristic PV proteins with conserved functional domains and have a non-coding genomic region with regulatory sequences to regulate and complete the viral life cycle. However, additional experimental evidence is needed to finally confirm the presence and biological functionality of the molecular features of both novel PVs. While MfuPV1, together with PVs identified in other macaques, is classified into the Alphapapillomavirus (Alpha-PV) species 12, MfuPV2 is most likely a representative of the novel viral species within the Alpha-PV genus. Their relatively high viral loads suggest that both PVs are etiologically linked with the development of the original neoplasms. 相似文献