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991.
Proeschold-Bell RJ Patkar AA Naggie S Coward L Mannelli P Yao J Bixby P Muir AJ 《Digestive diseases and sciences》2012,57(4):1083-1091
Background
Patients with chronic hepatitis C virus (HCV) infection have high rates of alcohol consumption, which is associated with progression of fibrosis and lower response rates to HCV treatment. 相似文献992.
Kim OY Chae JS Paik JK Seo HS Jang Y Cavaillon JM Lee JH 《Age (Dordrecht, Netherlands)》2012,34(2):415-425
Inappropriate interleukin-6 production is thought to play a role in the development of several age-related conditions including
atherosclerosis. This study aimed to determine whether aging affects circulating interleukin-6 (IL-6) levels. Healthy, nonobese
women (n = 208, 44.5 ± 0.70 years, 22.4 ± 0.17 kg/m2) were categorized into four age groups (22–31, 32–41, 42–51, and 52–63 years; cross-sectional study). Cytokine levels in
serum and those produced from peripheral blood mononuclear cell (PBMC) were measured. The oldest group had the highest circulating
levels of IL-6 and oxidized low-density lipoprotein (ox-LDL) and higher PBMC production of IL-6, tumor necrosis factor-α (TNF-α),
and interleukin-1 alpha (IL-1β). Additionally, significant interactions between age and menopause were found for serum IL-6
(P = 0.024), and TNF-α (P = 0.011) and IL-1β (P < 0.001) produced from PBMCs. Serum IL-6 levels positively correlated with age, waist–hip ratio (WHR), systolic blood pressure,
circulating levels of TNF-α, IL-1β, and ox-LDL, and urinary 8-epi-prostaglandin F2α. Multiple stepwise regression models identified the following factors for contributing to serum IL-6 levels: serum IL-1β,
menopause status, WHR, and serum TNF-α in mode I (R
2 = 0.302); serum IL-1β, age, serum TNF-α, and WHR (β = 0.197; P = 0.006) in model II (R
2 = 0.283). Sub-analysis was performed according to menopausal status. Serum IL-6 levels were positively associated with levels
of IL-6, TNF-α, and IL-1β in PBMC supernatants (unstimulated) from postmenopausal women, whereas these were negatively associated
in premenopausal women. In conclusion, circulating IL-6 levels may be interactively influenced by age and menopause. Additionally,
estrogen deprivation after menopause may enhance PBMC cytokine production in postmenopausal women, resulting in increased
IL-6 levels which are closely related to oxidative stress. 相似文献
993.
994.
Nicolas M. Van Mieghem Didier Tchetche Alaide Chieffo Nicolas Dumonteil David Messika-Zeitoun Robert M.A. van der Boon Olivier Vahdat Gill L. Buchanan Bertrand Marcheix Dominique Himbert Patrick W. Serruys Jean Fajadet Antonio Colombo Didier Carrié Alec Vahanian Peter P.T. de Jaegere 《The American journal of cardiology》2012,110(9):1361-1367
995.
Gallegos-Orozco JF Foxx-Orenstein AE Sterler SM Stoa JM 《The American journal of gastroenterology》2012,107(1):18-25; quiz 26
Constipation is one of the most frequent gastrointestinal disorders encountered in clinical practice in Western societies. Its prevalence increases with age and is more frequently reported in female patients. Chronic constipation has been associated with considerable impairment in quality of life, can result in large individual healthcare costs, and represents a burden to healthcare delivery systems. This review will focus on the definition, epidemiology, diagnostic approach, and non-pharmacologic as well as pharmacologic management of chronic constipation in the elderly, including an overview of new medications currently under clinical investigation. 相似文献
996.
997.
I Sagara B Fofana J Gaudart B Sidibe A Togo S Toure K Sanogo D Dembele A Dicko R Giorgi OK Doumbo AA Djimde 《The American journal of tropical medicine and hygiene》2012,87(1):50-56
Artemisinin-based combination therapies (ACTs) are the first-line treatment of uncomplicated malaria. The public health benefit and safety of repeated administration of a given ACT are poorly studied. We conducted a randomized trial comparing artemether-lumefantrine, artesunate plus amodiaquine (AS+AQ) and artesunate plus sulfadoxine-pyrimethamine (AS+SP) in patients 6 months of age and older with uncomplicated malaria in Mali from July 2005 to July 2007. The patient received the same initial treatment of each subsequent uncomplicated malaria episode except for treatment failures where quinine was used. Overall, 780 patients were included. Patients in the AS+AQ and AS+SP arms had significantly less risk of having malaria episodes; risk ratio (RR) = 0.84 (P = 0.002) and RR = 0.80 (P = 0.001), respectively. The treatment efficacy was similar and above 95% in all arms. Although all drugs were highly efficacious and well tolerated, AS+AQ and AS+SP were associated with less episodes of malaria. 相似文献
998.
999.
1000.
Luciana Soares de Andrade Freitas Oliveira Delano Oliveira Souza Frederico Sampaio Neves Jean Nunes dos Santos Paulo Sérgio Flores Campos Ieda Crusoé-Rebello 《Oral and maxillofacial surgery》2012,16(4):383-388