Synthesis, in vitro antimicrobial and antioxidant activities of chalcone and flavone derivatives holding allylic substitutions

In a wide search program towards new and efficient biological active agents, a series of chalcone and flavone derivatives holding allylic substitutions have been synthesized and tested for their in vitro antibacterial and antifungal activities. The synthesized compounds were tested in vitro against Gram-positive, Gram-negative bacteria, and the yeast Candidia kefir in comparison with control drugs (Sulfamethoxazole and Fluconazole). The antioxidant activity of the synthesized allylic chalcones and flavones was also assessed using two methods, including, 1,1-biphenyl-2-picrylhydrazyl (DPPH) radical scavenging, and reducing power assays and compared to reference drug Trolox.     

Cirrhosis and its complications:Evidence based treatment

Cirrhosis results from progressive fibrosis and is the final outcome of all chronic liver disease.It is among the ten leading causes of death in United States.Cirrhosis can result in portal hypertension and/or hepatic dysfunction.Both of these either alone or in combination can lead to many complications,including ascites,varices,hepatic encephalopathy,hepatocellular carcinoma,hepatopulmonary syndrome,and coagulation disorders.Cirrhosis and its complications not only impair quality of life but also decrease survival.Managing patients with cirrhosis can be a challenge and requires an organized and systematic approach.Increasing physicians’knowledge about prevention and treatment of these potential complications is important to improve patient outcomes.A literature search of the published data was performed to provide a comprehensive review regarding the management of cirrhosis and its complications.     

Soft tissue aneurysmal bone cyst of the mandible: Report of a case

We report the case of a 17-year-old boy with a soft tissue aneurysmal bone cyst (STABC) located in the posterior aspect of the right mandible. Conventional radiography revealed no positive findings. On the computed tomography scan, the lesion appeared to have a non-uniform intralesional density. Magnetic resonance imaging revealed an abnormal soft tissue masses with cystic component in the superficial part of right mandibular body and angle with intact cortex. Following histopathological examination, fibro-histiocytic proliferation, blood-filled spaces and multinucleated giant cells were seen and the lesion was diagnosed as a STABC. The mass together with underlying bone and periosteum on its periphery was surgically resected under general anesthesia. Thirty-six months after surgery the patient was assessed at outpatient clinic and found no sign of recurrence This may be only the first reported case of the mandible in the English literature of this extremely rare benign tumor occurring in soft tissue.     

The effect of glutaraldehyde base disinfectants on denture base resins

The effect of two alkaline glutaraldehyde base disinfectants on a heat-cured denture base resin was evaluated by the flexural strength, the repair flexural strength, and the surface morphology of the material that had been immersed up to 12 hours in the disinfecting solutions. The flexural strength of the material was not significantly affected by either disinfectant. The disinfectant with phenolic buffer caused surface pitting of the material after 10 minutes of immersion, and softening and swelling of the surface after 2 hours of immersion. No apparent surface change was observed with the regular alkaline formulation, however. Between the two repair resins, the autopolymerized resin yielded greater repair flexural strength than the light-cured repair resin. However, the repair flexural strength of autopolymerized resin seemed to be influenced by either disinfecting solution whereas the light-cured repair resin was not affected.