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排序方式: 共有1223条查询结果,搜索用时 125 毫秒
991.
Stefan D. Anker Aldo P. Maggioni Andrew J. Coats Gerasimos Filippatos Frank Ruschitzka Roberto Ferrari Massimo Francesco Piepoli Juan F. Delgado Jimenez Marco Metra Candida Fonseca Jaromir Hradec Offer Amir Damien Logeart Ulf Dahlstr?m Bela Merkely Jaroslaw Drozdz Eva Goncalvesova Mahmoud Hassanein Ovidiu Chioncel Mitja Lainscak Petar M. Seferovic Dimitris Tousoulis Ausra Kavoliuniene Friedrich Fruhwald Emir Fazlibegovic Ahmet Temizhan Plamen Gatzov Andrejs Erglis Cécile Laroche Alexandre Mebazaa 《European journal of heart failure》2016,18(6):613-625
992.
993.
994.
Csaba Polgár Erik Van Limbergen György Kovács Jaroslaw Lyczek Peter Niehoff Ferran Guedea Oliver J. Ott Vratislav Strnad On behalf of the GEC-ESTRO breast cancer working group 《Radiotherapy and oncology》2010,94(3):264-273
Purpose
To give recommendations on patient selection criteria for the use of accelerated partial-breast irradiation (APBI) based on available clinical evidence complemented by expert opinion.Methods and materials
Overall, 340 articles were identified by a systematic search of the PubMed database using the keywords “partial-breast irradiation” and “APBI”. This search was complemented by searches of reference lists of articles and handsearching of relevant conference abstracts and book chapters. Of these, 3 randomized and 19 prospective non-randomized studies with a minimum median follow-up time of 4 years were identified. The authors reviewed the published clinical evidence on APBI, complemented by relevant clinical and pathological studies of standard breast-conserving therapy and, through a series of personal communications, formulated the recommendations presented in this article.Results
The GEC-ESTRO Breast Cancer Working Group recommends three categories guiding patient selection for APBI: (1) a low-risk group for whom APBI outside the context of a clinical trial is an acceptable treatment option; including patients ageing at least 50 years with unicentric, unifocal, pT1-2 (?30 mm) pN0, non-lobular invasive breast cancer without the presence of an extensive intraductal component (EIC) and lympho-vascular invasion (LVI) and with negative surgical margins of at least 2 mm, (2) a high-risk group, for whom APBI is considered contraindicated; including patients ageing ?40 years; having positive margins, and/or multicentric or large (>30 mm) tumours, and/or EIC positive or LVI positive tumours, and/or 4 or more positive lymph nodes or unknown axillary status (pNx), and (3) an intermediate-risk group, for whom APBI is considered acceptable only in the context of prospective clinical trials.Conclusions
These recommendations will provide a clinical guidance regarding the use of APBI outside the context of a clinical trial before large-scale randomized clinical trial outcome data become available. Furthermore they should promote further clinical research focusing on controversial issues in the treatment of early-stage breast carcinoma. 相似文献995.
996.
997.
Peter Mitto Andreas Barankay Paul Späth Regula Kunkel Josef A. Richter 《Pediatric cardiology》1992,13(1):14-19
Summary In a prospective study results of central venous catheter (CVC) placements in a consecutive group of 500 patients with less than 20 kg body weight undergoing cardiac surgery were evaluated. The incidence of previous cardiac surgery was 21% and the incidence of factors preventing the primary puncture of the right jugular or innominate vein was 13.4%. The anesthesiologists were free to select the catheterization technique, site of puncture, and catheter type. All CVC insertions were performed prior to surgery under continuous circulatory monitoring and optimal positioning of the anesthetized patient.Ninety-six percent of all catheterizations were successful, 81% of them on the first attempt. In the 4% of cases where catheterization failed, a CVC had to be placed by the surgeon. Of all catheters, 66% were positioned via the right internal jugular (IJV) or innominate vein (IV), 8% via the left, 16% via an external jugular vein (EJV), and 5% via other veins. Seventy-six percent of CVC insertions were performed with the Seldinger technique. Of the four catheter types used in this study, double lumen catheters were most frequently selected (38%). Placement of 22-ga single lumen catheters was preferred in infants with less than 5 kg body weight, in spite of their tendency to kink. Observed complications (10% arterial puncture, 4% hematoma, and 1% intrathoracic bleeding) never required immediate surgical intervention. Careful selection of appropriate catheters, as well as extensive experience and knowledge of the anatomical structures involved in special heart defects, helped to keep the risk of complications low. 相似文献
998.
Magdalena Malejczyk Jaroslaw J
wiak Anna Osiecka Piotr I. Roszkowski Walentyna Mazurkiewicz-Smoktunowicz Tomasz T. Rogoziski Leszek Walczak Stefania Jabloska Slawomir Majewski Jacek Malejczyk 《International journal of cancer. Journal international du cancer》1997,73(1):16-19
The levels of type-I and type-II soluble TNF-α receptors (sTNF-Rs) were evaluated in sera from patients with various human-papillomavirus-(HPV)-associated benign and malignant anogenital lesions using specific enzyme-linked immunobiological assays. In patients with benign HPV6/11-associated condylomata acuminata, the levels of sTNF-RI were significantly increased, while sTNF-RII were in normal range. Both types of sTNF-Rs were in normal range in patients with benign HPV16-associated grade-I/II and grade-III cervical intra-epithelial neoplasia. However, their levels were significantly increased in patients with HPV16/18-associated squamous cervical cancer and anogenital Bowen's carcinoma. Sera from patients with condylomata acuminata and anogenital carcinomas displayed significantly increased TNF-α-inhibitory activity, as revealed by L929 cell-cytotoxicity assay. Increased serum TNF-α-inhibitory activity correlated with higher levels of sTNF-Rs. Furthermore, this inhibitory activity could be specifically abrogated by htr9 and utr1 monoclonal antibodies recognizing TNF-RI and TNF-RII respectively. Our results strongly suggest that serum sTNF-Rs may protect tumor cells from cytotoxic/cytostatic effects of locally released TNF-α, and that elevated levels of circulating sTNF-Rs may facilitate the growth of HPV-associated anogenital lesions. Int. J. Cancer 73:16–19, 1997. © 1997 Wiley-Liss, Inc. 相似文献
999.
Szymon Janczar Katarzyna Babol‐Pokora Izabela Jatczak‐Pawlik Kamila Wypyszczak Anna Klukowska Pawel Laguna Magdalena Kostrzewska Olga Wegner Jaroslaw Zielinski Andrzej Koltan Halina Bobrowska Irena Woznica-Karczmarz Lucja Dakowicz Marek Wlazlowski Iwona Ruranska Grzegorz Dobaczewski Monika Radwanska Grazyna Karolczyk Danuta Pietrys Walentyna Balwierz Tomasz Szczepaski Tomasz Urasiski Rafal Ploski Wojciech Mlynarski 《Haemophilia》2019,25(4):e311-e314
1000.
Galar M Piszcz J Bolkun L Szumowska A Kloczko J 《Clinical and applied thrombosis/hemostasis》2012,18(5):542-545
Protein Z (PZ) deficiency may induce bleeding as well as thrombosis. The aim of our study was to estimate the concentration of PZ in patients with acute leukemia. Plasma levels of PZ were determined in 76 patients with newly diagnosed acute leukemia ([AML], n = 50; acute lymphoblastic leukemia [ALL], n = 26) and 62 healthy participants. In the patients, mean plasma concentrations of PZ were statistically lower than in healthy individuals: AML (1.24 ± 0.11 μg/mL vs 1.58 ± 0.05 μg/mL P = .01) and ALL (1.19 ± 0.16 μg/mL vs 1.58 ± 0.05 μg/mL P = .01). Levels of PZ below the fifth percentile (0.873 μg/mL) of normal value distribution in control participants were found in 30% of patients with AML and ALL and in 3% of controls (P < .0001). In this AML subgroup, we found statistically significant correlation between episodes of bleeding and PZ level (P = .01). There was no such correlation in ALL group. The results suggest that PZ can be a cofactor associated with an increased bleeding tendency in patients with AML. 相似文献