全文获取类型
收费全文 | 1147篇 |
免费 | 34篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 89篇 |
儿科学 | 21篇 |
妇产科学 | 81篇 |
基础医学 | 125篇 |
口腔科学 | 6篇 |
临床医学 | 70篇 |
内科学 | 299篇 |
皮肤病学 | 9篇 |
神经病学 | 167篇 |
特种医学 | 15篇 |
外科学 | 93篇 |
综合类 | 13篇 |
预防医学 | 53篇 |
眼科学 | 42篇 |
药学 | 69篇 |
中国医学 | 2篇 |
肿瘤学 | 28篇 |
出版年
2023年 | 7篇 |
2022年 | 3篇 |
2021年 | 12篇 |
2020年 | 3篇 |
2019年 | 14篇 |
2018年 | 25篇 |
2017年 | 26篇 |
2016年 | 21篇 |
2015年 | 25篇 |
2014年 | 51篇 |
2013年 | 57篇 |
2012年 | 108篇 |
2011年 | 104篇 |
2010年 | 43篇 |
2009年 | 13篇 |
2008年 | 54篇 |
2007年 | 91篇 |
2006年 | 89篇 |
2005年 | 93篇 |
2004年 | 103篇 |
2003年 | 86篇 |
2002年 | 73篇 |
2001年 | 7篇 |
2000年 | 7篇 |
1999年 | 5篇 |
1998年 | 5篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 7篇 |
1993年 | 1篇 |
1992年 | 4篇 |
1991年 | 4篇 |
1989年 | 3篇 |
1988年 | 5篇 |
1987年 | 1篇 |
1986年 | 4篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1983年 | 4篇 |
1978年 | 2篇 |
1975年 | 3篇 |
1973年 | 3篇 |
1971年 | 1篇 |
1967年 | 1篇 |
1966年 | 2篇 |
1940年 | 1篇 |
1917年 | 1篇 |
排序方式: 共有1182条查询结果,搜索用时 31 毫秒
101.
Rola J 《Psychiatria polska》2007,41(2):203-216
The approach towards the issues of depression and mental health problems of mentally disabled persons is discussed in the paper. The author discussed the various susceptibilities, resistances and typical mental health disturbances of mentally disabled persons as well as their diagnostic criteria and methods of measuring them. A longer part of the paper concerns the approach towards depressive disorders in the population with developmental disabilities. 相似文献
102.
Sinkiewicz W Droźdź J Dubiel JS Filipiak KJ Rozentryt P Wierzchowiecki M Opolski G 《Kardiologia polska》2007,65(2):223-228
103.
Mak M Jarek D Nasuszny W Stanisławski R Arkowski J Klausa F Rogulski Ł Gemel M Skiba J Banasiak W 《Kardiologia polska》2007,65(4):427-429
A case of a patient with congenital anomaly of coronary blood vessels with left anterior descending artery starting from right coronary sinus is presented. The patient was operated on due to symptoms of myocardial ischaemia by carrying out an off-pump coronary artery bypass graft to left anterior descending artery and obtuse marginal artery, with a very good outcome. 相似文献
104.
105.
Lipiec P Uznańska B Krzemińska-Pakuła M Wejner-Mik P Chrzanowski L Kasprzak JD 《Kardiologia polska》2007,65(9):1119-1121
We present a case of severe complication of myocardial infarction -- acute mitral regurgitation caused by papillary muscle rupture. A 69-year-old man was admitted with chest pain lasting 1 hour and pulmonary oedema. ECG revealed ST-segment depression in leads II, III, aVF, V2-V6. Soon after admission the patient experienced respiratory disorders and consequently arrest. The patient was transferred in shock to the Department of Cardiothoracic Surgery, where he underwent successful artificial mitral valve implantation. One year later the patient is in good condition (NYHA class I) and the valve is fully functional. 相似文献
106.
107.
Wybieralska E Szpak K Górecki A Bonarek P Miękus K Drukała J Majka M Reiss K Madeja Z Czyż J 《Oncology reports》2011,26(2):447-453
In the present study, we investigated the effects of fenofibrate on the invasive potential of DU-145 human prostate cancer cells in the context of gap junctional intercellular coupling and the formation of reactive oxygen species. Time-lapse analyses of cell motility, accompanied by tests of cell viability, membrane microviscosity, reactive oxygen species accumulation and the function of gap junctional protein connexin 43 were performed in monolayer cultures of DU-145 cells following fenofibrate administration. Fenofibrate inhibited the motility of DU-145 cells and attenuated gap junctional intercellular coupling in a manner independent of its effects on cell viability, PPARα activation and cell membrane micro-viscosity. Instead, N-acetyl-L-cysteine, a scavenger of reactive oxygen species, restored cell motility and gap junctional coupling in fenofibrate-treated DU-145 cell populations. These data indicate that two parameters crucial for cancer cell metastatic potential, i.e. cell motility and gap junctional coupling, are inhibited by fenofibrate. Thus, fenofibrate affects prostate cancer cell invasion via an orchestrated action on versatile cancer cell properties determining this process. A novel mechanism of anti-invasive activity of fenofibrate, which depends on its interference with cell motility and the function of gap junctions regulated by reactive oxygen species, is suggested. 相似文献
108.
We present a case of a 57 year-old patient with a right ventricular metastasis of leiomyosarcoma. The patient was subjected to a tumour excision and a supplementary radiotherapy 12 years earlier. Non-characteristic symptoms and adverse medical history of coronary heart disease (three remote myocardial infarctions) delayed diagnosis and treatment. Because the disease was advanced, the patient was disqualified from surgical treatment. Good clinical condition, however, allowed for gemcitabine treatment, however, long-termed prognosis is poor. 相似文献
109.
Brzozowski Z Saczewski F Sławiński J Sanchez T Neamati N 《European journal of medicinal chemistry》2009,44(1):190-196
A series of novel 3-aroyl-2,3-dihydro-1,1-dioxo-1,4,2-benzodithiazines 15-28 as potential HIV-1 integrase (IN) inhibitors have been synthesized by the reduction of 3-aroyl-1,1-dioxo-1,4,2-benzodithiazines 1-14 with benzenesulfonyl hydrazide. All the compounds 15-28 inhibited IN mediated strand transfer reaction with IC(50) values ranging from 3 to 30 microM. The 3-(4-bromobenzoyl)-6-chloro-7-methyl-2,3-dihydro-1,1-dioxo-1,4,2-benzodithiazine 17 with the IC(50) values of 4+/-1 and 3+/-1 microM for 3'-processing and strand transfer, respectively, was the most potent. Compound 17 as well its analogues were 5-20-fold less potent in Y99S and H114A mutants, implicating these residues as potential drug-binding site. This is a first report implicating Y99S and H114A of IN core domain in drug-binding interactions. 相似文献