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51.
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The ability of two-component dyeing photoinitiating systems for the radical polymerization of 1,6-hexanediol diacrylate (HDDA) and 2-ethyl-2-(hydroxymethyl)-1,3-propanediol triacrylate (TMPTA) is presented. The systems under study comprised a hemicyanine dye as a sensitizer and iodonium salts that played a role of a coinitiator. The kinetic parameters of the polymerization reaction, such as the rate of polymerization (Rp) and the degree of conversion of monomer (C%), were estimated. The thermodynamic feasibility of an electron transfer process in the systems studied was verified and calculated using the Rehm–Weller equation. It was found that a benzoxazole derivative in the presence of iodonium salts effectively initiated the polymerization of acrylate monomers. The polymerization rates of about 10−7 s−1 and the degree of conversion of acrylate groups from 20% to 50% were observed. The effects of photoinitiator structures on the initiating ability and spectroscopic properties of sensitizers are described in this article.The ability of two-component dyeing photoinitiating systems for the radical polymerization of 1,6-hexanediol diacrylate (HDDA) and 2-ethyl-2-(hydroxymethyl)-1,3-propanediol triacrylate (TMPTA) is presented. 相似文献
53.
HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes
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Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family. It is localized within the cytoplasm and has unique substrate specificities for nonhistone proteins, such as α‐tubulin. Furthermore, it plays a major role in protein aggregate formation and recently was demonstrated to interact with the microtubule associated protein tau and tau was identified as a possible substrate for HDAC6 in neurons. This study was undertaken to investigate whether HDAC6 is present in oligodendrocytes and whether it is involved in tubulin and tau acetylation in these cells. We show for the first time that HDAC6 is expressed in cultured rat brain oligodendrocytes. Its inhibition by the specific HDAC6 inhibitor tubastatin A (TST) leads to morphological alterations, microtubule bundling, and tubulin acetylation, and changes in tau‐isoform expression and phosphorylation. Furthermore, the microtubule binding activity of tau was reduced. Using the oligodendroglial cell lines OLN‐t40 and OLN‐t44, which were genetically engineered to express either the longest human tau isoform with four microtubule binding repeats (4R‐tau), or the shortest tau isoform with three repeats (3R‐tau), respectively, we demonstrate that tau is acetylated by HDAC6 within the 4R‐binding domain. Tau acetylation reduced its turnover rate and acetylated tau was degraded slower in these cells. TST and shRNA‐mediated knockdown of HDAC6 in oligodendroglia cells caused an increase in pathological hyperphosphorylated tau detectable with the 12E8 antibody. Hence HDAC6 and dysregulation of the deacetylation and acetylation process in oligodendrocytes may contribute to diseases with oligodendroglial pathology. GLIA 2014;62:535–547 相似文献
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The paper analyses the forming of the surgical instrument handles made of Grade 2 titanium sheets. Sheet metal forming is a technology ensuring high strength and light weight of products. Replacing stainless steels with titanium further reduces instrument weight and additionally provides the required resistance to corrosive environments typical for surgeries. The low instrument weight is important to prevent fatigue of surgeons and allow them to maintain high operational accuracy during long term surgeries. The numerical analysis of the technological process was performed in order to adapt it to forming tool handles using titanium sheets instead of steel sheets. The numerical calculations were experimentally verified. It was found that, in the case of titanium handles, it is necessary to use a blank holder in the first forming operation to eliminate sheet wrinkling in the flange area. The shape and dimensional accuracy of the drawn part after trimming were high enough and the 4th forming operation became unnecessary. Moreover, the process modification included lubrication using rapeseed oil with the addition of boric acid, which effectively prevents the galling of titanium on the working surfaces of the steel tools and ensures a more uniform distribution of plastic strains in the drawn part. 相似文献
56.
Karolina Mozelewska Zbigniew Czech Marcin Bartkowiak Magorzata Nowak Paulina Bednarczyk Piotr Niezgoda Janina Kabatc Agnieszka Skotnicka 《Materials》2022,15(1)
In this study, syntheses of acrylate copolymers were performed based on the monomers butyl acrylate (BA), 2-ethylhexyl acrylate (2-EHA), and acrylic acid (AA) and the second-type unsaturated photoinitiator 4-acryloyloxybenzophenone (ABP). The structure of the obtained copolymers was confirmed via FT-IR spectroscopic analysis, and the viscosity and the content of non-volatile substances were determined. The adhesive films were then coated and cross-linked using ultraviolet radiation in the UV-C range at various doses (5–50 mJ/cm2). Due to the dependence of the self-adhesive properties of the adhesive layer on the basis weight, various basis weights of the layer in the range of 30–120 g/m2 were tested. Finally, the self-adhesive properties were assessed: tack, peel adhesion, shear strength (cohesion) at 20 °C and 70 °C, as well as the SAFT test and shrinkage. The aim of the study was to determine the effect of the type of monomer used, the dose of ultraviolet radiation, and the basis weight on the self-adhesive and usable properties of the obtained self-adhesive tapes. 相似文献
57.
A series of 2-phenacylbenzoxazole difluoroboranes named BODIPY dyes (1–8) was designed and applied as photosensitizers (PS) for radical photopolymerization of acrylate monomer. The light absorption within the ultraviolet-visible (UV–Vis) range (λmax = 350–410 nm; εmax = 23,000–42,500 M−1cm−1), that is strongly influenced by the substituents on the C3 and C4 atoms of phenyl ring, matched the emission of the Omnicure S2000 light within 320–500 nm. The photosensitizer possess fluorescence quantum yield from about 0.005 to 0.99. The 2-phenacylbenzoxazole difluoroboranes, together with borate salt (Bor), iodonium salt (Iod) or pyridinium salt (Pyr) acting as co-initiators, can generate active radicals upon the irradiation with a High Pressure Mercury Lamp which initiates a high-performance UV–Vis light-induced radical polymerization at 320–500 nm. The polymers obtained are characterized by strong photoluminescence. It was found that the type of radical generator (co-initiator) has a significant effect on the kinetic of radical polymerization of acrylate monomer. Moreover, the chemical structure of the BODIPY dyes does not influence the photoinitiating ability of the photoinitiator. The concentration of the photoinitiating system affects the photoinitiating performance. These 2-phenacylbenzoxazole difluoroborane-based photoinitiating systems have promising applications in UV–Vis-light induced polymerization. 相似文献
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59.
L. J. Zeldis E. L. Alling A. B. McCoord J. P. Kulka 《The Journal of experimental medicine》1945,82(6):411-430
Electrophoretic patterns of human and dog plasma are markedly altered by the extraction of a large part of the plasma lipids. Total electrophoretic areas, relative areas of individual electrophoretic components, and electrophoretic albumin: globulin ratios undergo change. For human plasma, such extractions confirm previous observations that a particularly rich lipid content characterizes beta globulin. Abnormally large beta peaks regularly occur in the presence of elevated plasma lipids. Marked increases in gamma globulin, however, are also found to be due in large part to elevated plasma lipid levels in certain abnormal human plasmas. The greatest relative amount of lipid in dog plasma, in contrast to human plasma, is associated not with the beta globulin, but with components usually designated as alpha globulins. Not only the areas, but the configuration and the number of alpha globulin peaks in dog plasma are altered by the extraction of plasma lipids. The results demonstrate that increased alpha globulin areas which occur in the plasma of hypoproteinemic dogs are due in large part to elevated plasma lipid levels. 相似文献