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排序方式: 共有1083条查询结果,搜索用时 15 毫秒
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Kristen E. Pauken Osmaan Shahid Kaitlyn A. Lagattuta Kelly M. Mahuron Jacob M. Luber Margaret M. Lowe Linglin Huang Conor Delaney Jaclyn M. Long Megan E. Fung Kathleen Newcomer Katy K. Tsai Melissa Chow Samantha Guinn Juhi R. Kuchroo Kelly P. Burke Jason M. Schenkel Michael D. Rosenblum Adil I. Daud Arlene H. Sharpe Meromit Singer 《The Journal of experimental medicine》2021,218(4)
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Gramen Tontchev M.D. Nanette B. Silverberg M.D. Edward Shlasko M.D. Carol Henry R.D.M.S. Jaclyn L. Roberts M.D. Malcolm Z. Roth M.D. 《Pediatric dermatology》2014,31(5):625-629
Harlequin ichthyosis (HI) is a rare autosomal recessive disorder of cornification in which children are born with an extremely thick stratum corneum that becomes a restrictive circumferential encasement around the orifices, limbs, chest, and abdomen, resulting in limb contractures. We present a neonate diagnosed in utero with HI. The infant was born with encasing bands of thickened skin creating strictures that were causing digital and limb cyanosis (compartment syndrome). We treated the child using a new technique of lysis of the encasing bands that we call linear band incision, using a new escharotomy‐like procedure while the infant was undergoing a 3‐week course oral acitretin therapy. The technique involved linear incision and lysis of encasements that resulted in reperfusion of the injured limbs and prevention of further digital necrosis. The child is currently a healthy 8‐year‐old boy with skin manifestations resembling congenital ichthyosiform erythroderma. He has use of all of the limbs that were released in the procedures and is maintained on frequent application of bland emollients. Linear band incision is a potentially life‐ and limb‐saving technique in children with HI. 相似文献
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Jaclyn M. Goodrich Niladri Basu Alfred Franzblau Dana C. Dolinoy 《Environmental and molecular mutagenesis》2013,54(3):195-203
Modification of the epigenome may be a mechanism underlying toxicity and disease following chemical exposure. Animal and human data suggest that mercury (Hg) impacts DNA methylation. We hypothesize that methylmercury and inorganic Hg exposures from fish consumption and dental amalgams, respectively, may be associated with altered DNA methylation at global repetitive elements (long interspersed elements, LINE‐1) and candidate genes related to epigenetic processes (DNMT1) and protection against Hg toxicity (SEPW1, SEPP1). Dental professionals were recruited at Michigan Dental Association (MDA) meetings in 2009 and 2010. Subjects (n = 131) provided survey data (e.g. exposure sources, demographics) and biological samples for Hg measurement and epigenetic analysis. Total Hg was quantified via atomic absorption spectrophotometry in hair and urine, indicative of methylmercury and inorganic Hg exposures, respectively. Global repetitive and candidate gene methylation was quantified via pyrosequencing of bisulfite converted DNA isolated from buccal mucosa. Hair Hg (geometric mean (95% CI): 0.37 (0.31–0.44) µg/g) and urine Hg (0.70 (0.60–0.83) µg/L) were associated with sources of exposure (fish consumption and dental amalgams, respectively). Multivariable linear regression revealed a trend of SEPP1 hypomethylation with increasing hair Hg levels, and this was significant (P < 0.05) among males. The trend remained when excluding non‐dentists. No significant relationships between urine Hg and DNA methylation were observed. Thus, in a limited cohort, we identified an association between methylmercury exposure and hypomethylation of a potentially labile region of the genome (SEPP1 promoter), and this relationship was gender specific. Environ. Mol. Mutagen. 54:195–203, 2013. © 2013 Wiley Periodicals, Inc. 相似文献
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Jaclyn YOONG Jo‐An SEAH Katherine HAMILTON Lee Na TEO Geoffrey CHONG 《Asia-Pacific Journal of Clinical Oncology》2012,8(4):325-329
Aims: Benefits to patients from systemic anti‐cancer therapies (SACT) occur at a cost of significant toxicities that can be life threatening. Published data of SACT mortality outside clinical trials is limited with no published Australia data. We aim to establish local outcomes at a regional Victorian oncology center to allow comparison with limited international data. Methods: An audit was undertaken at Ballarat Health Services to analyze all deaths occurring within 30 and 60 days of receiving SACT (cytotoxic chemotherapy and targeted therapy) for epithelial malignancies and hematological malignancies (excluding acute leukemia), over a 12‐month period. Hormonal therapy was excluded. Results: Between 1 January and 31 December 2008, 378 patients received SACT. In total 13 deaths (3.4%) occurred within 30 days following SACT. Three deaths (23%) were definitely treatment‐related – neutropenic sepsis, pneumocystis pneumonia and bowel perforation, respectively. Eight deaths (62%) were definitely unrelated to treatment. Most deaths were due to disease progression (six patients) For two patients (15%), the cause of death was unknown. Most patients were treated with palliative intent. Most patients were receiving first‐line treatment (seven patients, 50%). A further five deaths (1.3%) occurred 31–60 days after SACT, four of which were due to disease progression. Conclusion: Our local outcome data are comparable to limited current international data. This type of audit reviews local outcomes and identifies factors contributing to mortality in order to improve standards of care. We encourage similar audits to establish national benchmarks of 30‐day mortality rate. 相似文献
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Zain Chagla Natasha Aleksova Jaclyn Quirt Joel Emery Christian Kraeker Shariq Haider 《The Canadian Journal of Infectious Diseases & Medical Microbiology》2014,25(4):225-226
Melioidosis is an infection endemic to Southeast Asia and Northern Australia, and is associated with significant morbidity and mortality. The present report describes a case of chronic melioidosis in a returning traveller from the Philippines. Clinical suspicion of this illness is warranted in individuals with a history of travel to endemic regions. Safety in handling clinical specimens is paramount because laboratory transmission has been described. 相似文献
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Erika J. Wolf Ci-Di Chen Xiang Zhao Zhenwei Zhou Filomene G. Morrison Nikolaos P. Daskalakis Annjanette Stone Steven Schichman Jaclyn Garza Grenier Dana Fein-Schaffer Bertrand R. Huber Traumatic Stress Brain Research Group Carmela R. Abraham Mark W. Miller Mark W. Logue 《Neuropsychopharmacology》2021,46(4):721
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