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991.
992.
An enzymatic approach to configurationally rare trans‐androsteronyl‐α‐glucoside and Its potential anticancer application
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Feng‐Pai Chou Chia‐Tse Tsai Ya‐Sheng Chiou Yi‐Ju Chen Meng‐Erh Li Ting‐Wei Guo Jason WenJay Lyu Sheng‐Hao Chou Tung‐Kung Wu 《Chemical biology & drug design》2017,89(1):61-66
Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl‐α‐glucosides. Investigation of trans‐androsteronyl‐α‐glucoside on tamoxifen‐treated MCF‐7 breast cancer cells shows dose‐dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl‐α‐glucosides with useful biological activities. 相似文献
993.
Laforce Robert Jr Dallaire-Théroux Caroline Racine Annie M. Dent Gersham Salinas-Valenzuela Cristian Poulin Elizabeth Cayer Anne-Marie Bédard-Tremblay Daphnée Rouleau-Bonenfant Thierry St-Onge Frédéric Schraen-Maschke Susanna Beauregard Jean-Mathieu Sergeant Nicolas Puymirat Jack 《Journal of neurology》2022,269(7):3579-3587
Journal of Neurology - To investigate Tau pathology using multimodal biomarkers of neurodegeneration and neurocognition in participants with myotonic dystrophy type 1 (DM1). We recruited twelve... 相似文献
994.
Neuhaus Emily Kang Veronica Youn Kresse Anna Corrigan Sarah Aylward Elizabeth Bernier Raphael Bookheimer Susan Dapretto Mirella Jack Allison Jeste Shafali McPartland James C. Van Horn John D. Pelphrey Kevin Webb Sara Jane 《Journal of autism and developmental disorders》2022,52(1):454-462
Journal of Autism and Developmental Disorders - Aggressive behaviors are common among youth with autism spectrum disorder (ASD) and correlate with pervasive social-emotional difficulties.... 相似文献
995.
996.
Yu-Chih?Lin Li-Chin?Tsai James?Chun-I?Lee Kuo-Lan?Liu Jason?Tze-Cheng?Tzen Adrian?Linacre Hsing-Mei?HsiehEmail author 《Forensic science, medicine, and pathology》2016,12(2):128-138
Purpose
Knowledge of the composition of complex body fluid mixtures may aid forensic investigations greatly. However, many of the traditional tests are presumptive in nature and can lead to ambiguous results. The aim of this study is to establish a reliable method to identify various biofluids via analysis of their DNA methylation profiles.Methods
A total of eight biofluid-specific methylated markers for saliva, venous blood, vaginal fluids, and semen were isolated from the open database of Infinium HumanMethylation450 BeadChip. These biofluid-specific markers, a control marker to confirm bisulfite conversion, and a gender marker, were combined into a 10-plex methylation-specific PCR single-base-extension (MSP-SBE) system.Results
Analysis of 65 DNA samples isolated from venous blood, semen, vaginal fluid, saliva, and menstrual blood that had been treated with bisulfite, resulted in all eight markers detecting the body fluid to which they were designed. Unambiguous body fluid identification occurred from both single sources of body fluids and complex mixtures. A threshold was devised for each marker to minimize the chance of a false inclusion. The efficacy of the assay and application to forensic practice was demonstrated using five non-probative samples from real alleged sexual assault cases. The system unambiguously determined the biofluid types for the non-probative forensic samples that previously resulted in inconclusive or conflicting results using traditional tests.Conclusions
The results demonstrated the 10-plex MSP-SBE system established in this study is both sensitive and specific when applied to body fluid identification and can be readily adopted into forensic practice.997.
Long‐Term Trajectories of PTSD in Vietnam‐Era Veterans: The Course and Consequences of PTSD in Twins
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Kathryn M. Magruder Jack Goldberg Christopher W. Forsberg Matthew J. Friedman Brett T. Litz Viola Vaccarino Patrick J. Heagerty Theresa C. Gleason Grant D. Huang Nicholas L. Smith 《Journal of traumatic stress》2016,29(1):5-16
We estimated the temporal course of posttraumatic stress disorder (PTSD) in Vietnam‐era veterans using a national sample of male twins with a 20‐year follow‐up. The complete sample included those twins with a PTSD diagnostic assessment in 1992 and who completed a DSM‐IV PTSD diagnostic assessment and a self‐report PTSD checklist in 2012 (n = 4,138). Using PTSD diagnostic data, we classified veterans into 5 mutually exclusive groups, including those who never had PTSD, and 4 PTSD trajectory groups: (a) early recovery, (b) late recovery, (c) late onset, and (d) chronic. The majority of veterans remained unaffected by PTSD throughout their lives (79.05% of those with theater service, 90.85% of those with nontheater service); however, an important minority (10.50% of theater veterans, 4.45% of nontheater veterans) in 2012 had current PTSD that was either late onset (6.55% theater, 3.29% nontheater) or chronic (3.95% theater, 1.16% nontheater). The distribution of trajectories was significantly different by theater service (p < .001). PTSD remains a prominent issue for many Vietnam‐era veterans, especially for those who served in Vietnam. 相似文献
998.
Meghan H. Pearl Anjali B. Nayak Robert B. Ettenger Dechu Puliyanda Miguel Fernando Palma Diaz Qiuheng Zhang Elaine F. Reed Eileen W. Tsai 《Pediatric nephrology (Berlin, Germany)》2016,31(8):1341-1348
Background
Current therapeutic strategies to effectively treat antibody-mediated rejection (AMR) are insufficient. Thus, we aimed to determine the benefit of a therapeutic protocol using bortezomib for refractory C4d + AMR in pediatric kidney transplant patients.Methods
We examined seven patients with treatment-refractory C4d + AMR. Immunosuppression included antithymocyte globulin or anti-CD25 monoclonal antibody for induction therapy with maintenance corticosteroids, calcineurin inhibitor, and anti-metabolite. Estimated glomerular filtration rate (eGFR) calculated by the Schwartz equation, biopsy findings assessed by 2013 Banff criteria, and human leukocyte antigen (HLA) donor-specific antibodies (DSA) performed using the Luminex single antigen bead assay were monitored pre- and post- bortezomib therapy.Results
Seven patients (86 % male, 86 % with ≥6/8 HLA mismatch, and 14 % with pre-formed DSA) age 5 to 19 (median 15) years developed refractory C4d + AMR between 1 and 145 (median 65) months post-transplantation. All patients tolerated bortezomib. One patient had allograft loss. Of the six patients with surviving grafts (86 %), mean pre-bortezomib eGFR was 42 ml/min/1.73 m2 and the mean 1 year post-bortezomib eGFR was 53 ml/min/1.73 m2. Five of seven (71 %) had improvement of histological findings of AMR, C4d staining, and/or acute cellular rejection. Reduction in HLA DSAs was more effective for class I than class II.Conclusions
Bortezomib appears safe and may correlate with stabilization of eGFR in pediatric kidney transplant patients with refractory C4d + AMR.999.
Herb formula enhances treatment of impotent patients after penile venous stripping: a randomised clinical trials
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Herbs have been regarded as aphrodisiacs in treating impotence for many centuries despite little true scientific evidence. Our latest refined penile venous stripping (PVS) technique is effective in treating impotence, although this procedure remains controversial. A synergic effect of PVS and oral herbs was confirmed in our practice but lacked rigorous scientific proof. The objective of this report was to review our experience with this combination. From August 2010 to May 2014, 263 males underwent PVS. Among these, 67 unsatisfied men chose additional salvage therapy and were randomly assigned to oral herbs (n = 35) or placebo treatment (n = 32) which replaced herb eventually. All were evaluated with the international index of erectile function (IIEF‐5) scoring and our dual pharmaco‐cavernosography. The pre‐op IIEF‐5 score for the herb group was 9.7 ± 3.7, post‐operative 13.9 ± 3.3 and post‐herb 19.6 ± 3.4, while the control group scores were as follows: pre‐op 9.3 ± 4.1, post‐op 14.5 ± 3.6, post‐placebo 15.1 ± 3.5 and post‐herb 19.9 ± 3.2. Although there was no significant difference between the two groups pre‐operatively, post‐operatively and post‐herb, a statistically significant difference was found post‐salvage therapy (19.6 ± 3.4 versus 15.1 ± 3.6, P < 0.001). It appears that the combination of oral herbs and PVS treatment provides an enhanced outcome to impotent patients refractory to medicine and unsatisfied with PVS monotherapy alone. 相似文献
1000.