广东省中医院的经济学评价

对广东省中医院的资源状况、潜在竞争力和经营业绩进行了初步的分析 ,根据这些指标的变化情况分析评价广东省中医院的经营状况、发现存在的问题 ,为医院的进一步发展提供建议。     

广东省中医院人际氛围调查研究

本研究对广东省中医院的人际沟通,以及群体内聚力进行初步调查,了解了管理者的人际沟通、组织内聚力的现状与特点,以及可能存在的问题,为探讨在综合医院,加强员工的凝聚力,挖掘内部潜力,期望为进一步制定有效的管理改善方案,提高医院管理水平,改善组织沟通,增强组织内聚力等提供科学依据.     

临床试验中多处理组比较期中分析方法研究

目的 :介绍临床试验中多处理组比较期中分析方法。方法 :在多处理组比较分析方法的基础上 ,将两处理组比较成组序贯期中分析方法进一步扩展用于多处理组比较期中分析。结果 :多处理组期中分析包括各组的总检验和处理组间的两两比较。结论 :多处理组期中分析的关键是每次期中分析时界值的确定     

鼓膜置管治疗小儿分泌性中耳炎108例分析

目的了解鼓膜置管加鼓室注药对小儿分泌性中耳炎的治疗效果.方法回顾性调查小儿分泌性中耳炎108例鼓膜置管及鼓室注药后的疗效.结果鼓膜置管术有效率为92.1%(152/165).结论鼓膜置管加鼓室注药较适合小儿分泌性中耳炎的治疗.     

内皮抑素治疗人喉癌裸鼠模型的实验研究

目的 研究内皮抑素对裸鼠喉鳞状细胞癌皮下移植模型的抑瘤作用,探讨其抑瘤机制及人喉癌生物治疗新方法。方法 建立人喉癌Hep-Ⅱ细胞株裸鼠皮下接种模型。应用内皮抑素治疗,观察肿瘤生长情况,对用药后肿瘤组织进行病理学检查,通用型二步法免疫组化检查及电镜观察。计数微血管密度(microvessel density,MVD),计算增殖细胞核抗原(proliferationg cell nuclear antigen,PCNA)和血管内皮生长因子(vascuoar endothelial growth factor,VEGF)阳性率。结果 在实验组与对照组之间,鼠净重、瘤重、瘤体积及瘤重/鼠净重,经t检验P值<0.05或<0.01,差异均有显著性意义,抑瘤率为45.9％。病理学检查及电镜观察表明,实验组应用内皮抑素治疗肿瘤生长受到抑制,细胞分裂少见,可见肿瘤细胞的坏死凋亡,新生血管明显减少。MVD、PCNA及VEGF表达在实验组明显低于对照组,经t检验P值分别为<0.01、<0.05、<0.05,差异均有显著性意义。结论 内皮抑素可显著抑制人喉癌裸鼠模型肿瘤的生长和发展,其可能机制为抑制肿瘤血管生成。     

The use of an ambulatory,automatic sleep recording device (QUISI™ Version 1.0) in the evaluation of primary snoring and obstructive sleep apnoea

The use of an ambulatory, automatic sleep recording device (QUISI? Version 1.0) in the evaluation of primary snoring and obstructive sleep apnoea Electroencephalogram (EEG) evaluation with polysomnography (PSG) according to the Rechtschaffen & Kales (R&K) rules is time and cost consumptive, but ambulatory polygraphy systems do not allow EEG recording routinely. As a consequence, the number of sleep disordered events cannot be calculated exactly. QUISI is a one‐channel, self‐applicable ambulatory EEG recording device. The present study was designed as a prospective, non‐randomized clinical trial. This investigation evaluated the results of 40 patients with primary snoring and obstructive sleep apnoea measured with level 1 PSG and QUISI simultaneously. Fifteen patients (37.5%) were primary snorers with normal sleep profiles, whereas 25 patients (62.5%) suffered from obstructive sleep apnoea (OSA) with a Respiratory Disturbance Index (RDI) of 38.6 ± 23.8. The mean total sleeping time (TST) was underestimated by 4.5%, while Sleep Efficiency Index (SEI) was understimated by 4.6% by the QUISI device compared with PSG. The correlation between the QUISI and the PSG estimates for single sleep stages demonstrated only moderate correlation. The statistical significance for sleep stage 2 was r = 0.42, P = 0.002; for sleep stage 3/4, r = 0.31, P = 0.02; and for WAKE, r = 0.33, P = 0.01. Sleep stage 2 as well as sleep stage 3/4 were underestimated by QUISI substantially (difference: ?5.6% and ?10.3%), while WAKE was overestimated by QUISI to a larger amount (difference: +10.4%). Sensitivity and specificity of QUISI to recognize pathological sleep profiles compared with PSG/R&K were 0.92 and 0.96 respectively. QUISI is able to evaluate normal versus altered sleep profiles in patients with primary snoring and OSA. Comparing the quartile ranges, we found substantial differences between QUISI and PSG/R&K. QUISI gives an impression of sleep architecture and objective verification of a sleep disturbance in an ambulant setting but cannot replace the sleep laboratory‐based PSG.     

Rncat先天性白内障小鼠的晶状体形态学研究

目的　研究Crygs基因发生突变的rncat先天性白内障小鼠的晶状体组织形态学改变。方法　使用裂隙灯观察rncat白内障小鼠自出生后晶状体混浊的形态改变。并取白内障小鼠的晶状体进行光镜、透射电镜和扫描电镜的检查 ,同时以正常昆明小鼠为对照。结果　发现rncat小鼠白内障是双眼逐渐形成的核心性混浊。病理检查发现晶状体上皮细胞的异常增殖 ,去核纤维化的过程受阻。电镜检查发现晶状体纤维的异常排列和细胞间连接结构的异常。结论　Crygs基因突变可导致rncat白内障小鼠晶状体上皮细胞的变性和晶状体纤维的排列紊乱和细胞间连接的结构改变。     

难治性青光眼半导体激光经巩膜睫状体光凝术

目的　评价半导体激光经巩膜睫状体光凝术治疗难治性青光眼的效果和安全性。方法　 68例 (69眼 )接受治疗 ,术后随访 6～ 17月。分析末次治疗后第 6月的眼压、视力和眼部症状。结果　无光感组 (3 6眼 ) :光凝术前眼压 (61.16± 12 .44 )mmHg(1mmHg =0 .13 3kPa) ,末次光凝术后第 6月后 3 3眼眼压 (2 9.67± 6.79)mmHg。 3眼眼球萎缩 ,12眼需 2次或多次治疗。光感及光感以上组 (3 3眼 ) :光凝术前眼压 (5 1.72± 13 .85 )mmHg ,末次光凝术后第 6月眼压 (2 1.42± 8.2 2 )mmHg。其中 11眼需要 2次或 3次光凝术 ,4眼 3次光凝术后眼压仍高于 2 1mmHg。结论　半导体激光经巩膜睫状体光凝术是一种简单、安全、有效的治疗难治性青光眼的方法 ,但常需要重复治疗。     

卡马西平和托吡酯联合治疗复杂部分性癫痫29例

目的观察卡马西平和托吡酯联合治疗复杂部分性癫痫的临床疗效及安全性.方法对29例患儿在单用卡马西平治疗的基础上,加用托吡酯联合治疗.结果加用托吡酯后疗效明显,总有效率达69%,发作完全控制率占38%.结论研究结果表明,两药联合治疗复杂部分性癫痫是安全有效的.