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991.
JOHN P. MULHALL ANDREW E. JAHODA MICHAEL CAIRNEY BRYAN GOLDSTEIN ROD LEITZES JORDAN WOODS TERRY PAYTON ROBERT J. KRANE IRWIN GOLDSTEIN 《The Journal of urology》1999,162(4):1291-1294
PURPOSE: Penile self-injection therapy, a second line treatment for erectile dysfunction, is the most efficacious means of reestablishing functional erections when first line therapies fail and the patient wants to avoid penile prosthesis implantation. Despite high efficacy rates, injection therapy has high dropout rates. To our knowledge studies to date analyzing patient attrition have reviewed small numbers of patients followed for only short periods. We elucidate the main reasons for patient dropout in a large penile self-injection program with long-term followup. MATERIALS AND METHODS: A questionnaire was mailed to 1,424 patients who completed the office training and home use phases of a penile self-injection program. RESULTS: The overall attrition rate was 31% of the 720 men who completed the questionnaire, with a mean followup of 38 months. The main reasons for dropout were cost of therapy, patient and partner problems with the concept of penile injection, lack of partner availability and spontaneous improvement in erections. Lack of efficacy of therapy was the primary reason for only 1 of 7 dropouts. Furthermore, adverse effects of penile injections (priapism, penile nodules, pain) appeared to be only minor contributors to dropout. CONCLUSIONS: To our knowledge this study is the largest published, single center cohort of patients treated with injection and followed for an analysis of dropout rates. Based on study data a reduction in dropout rates may be achieved by keeping the cost of therapy low, and ensuring patient and partner education as well as continued support throughout treatment. 相似文献
992.
993.
CHRISTINE IMMS BAPPSC MSC PHD JOHN CARLIN BSC PHD ANN‐CHRISTIN ELIASSON BSC PHD 《Developmental medicine and child neurology》2010,52(2):153-159
Aim To examine the stability of caregiver‐reported classifications of function of children with cerebral palsy (CP) measured 12 months apart. Method Participants were 86 children (50 males, 36 females) with CP of all motor types and severities who were recruited into a population‐based longitudinal study. Children were aged 11 years 8 months (SD 6mo) on the first assessment and 12 years 8 months (SD 6mo) on the second assessment. Data were gathered through a postal survey. Caregivers reported on the Manual Ability Classification System (MACS), the Gross Motor Function Classification System (GMFCS), and other demographic characteristics. The percentage absolute agreement and the intraclass coefficient correlation (ICC) equivalent of the weighted kappa were calculated to assess consistency between assessments for the MACS and GMFCS. We also examined associations between changes in classification and background variables. Results Fifty‐eight caregivers (67%) classified their child at the same MACS level on both assessments (ICC 0.92; 95% confidence interval [CI] 0.87–0.95), whereas 79% did so with the GMFCS (ICC 0.95; 95% CI 0.92–0.96). The evidence suggests that caregivers who were not born in Australia or who spoke a language other than English in the home were more likely to classify their child differently on the MACS at the second assessment, although this was not evident for the GMFCS. Interpretation Caregiver‐reported MACS and GMFCS levels were generally stable over 12 months. 相似文献
994.
995.
D. WYN DAVIES RAY J. WAINWRIGHT † MARK A. TOOLEY DAVID LLOYD ANTHONY W. NATHAN ROWORTH A. J. SPURRELL A. JOHN CAMM 《Pacing and clinical electrophysiology : PACE》1986,9(2):200-208
Pacemaker recognition of pathological tachycardia relies on heart rate analysis. This can lead to misdiagnosis when sinus tachycardia exceeds the preset tachycardia response trigger rate. We have explored a method for automatic tachycardia diagnosis by analysis of bipolar endocardial electrogram morphology. Electrograms were recorded from 11 patients (pts) during sinus rhythm and during a total of 20 abnormal rhythms: retrograde atrial depolarization from ventricular pacing in six patients; atrioventricular reentry tachycardia in five patients with intermittent left bundle branch block in one of those; AV nodal reentry tachycardia in five patients and ventricular tachycardia in three patients. Posture and respiration were varied during all rhythms except ventricular tachycardia. The electrograms were then digitized and converted to a form in which the amplitudes were proportional to the rates of change of the original electrogram (equivalent to a first time derivative); the derived signal was then analyzed by a new gradient pattern detection (GPD) program. Analysis of the processed atrial signals by GPD resulted in automatic recognition of abnormal rhythms from sinus rhythm in all cases except for one patient's retrograde atrial depolarization. At the ventricular level, GPD successfully distinguished all abnormal rhythms from sinus rhythm including recognition of left bundle branch block and varying degrees of preexcitation. Respiratory and postural variation did not affect the recognition process. We conclude that electrogram GPD has successfully and automatically detected a variety of arrhythmias which can be treated by implantable pulse generators and may, therefore, be a useful adjunct to heart rate analysis in future generations of such antitachycardia pacemakers. 相似文献
996.
Atrial Pacing Lead Location Alters the Hemodynamic Effects of Atrial-Ventricular Delay in Dogs with Pacing Induced Cardiomyopathy 总被引:1,自引:0,他引:1
DOUGLAS A. HETTRICK JACQUELINE R. MITTELSTADT FRANZ KEHL† TOBIAS T. KRESS† JOHN P. TESSMER† JOHN G. KROLIKOWSKI† JUDY R. KERSTEN† DAVID C. WARLTIER† ‡ § PAUL S. PAGEL† ‡ 《Pacing and clinical electrophysiology : PACE》2003,26(4P1):853-861
HETTRICK, D.A., et al .: Atrial Pacing Lead Location Alters the Hemodynamic Effects of Atrial Ventricular Delay in Dogs with Pacing Induced Cardiomyopathy. The role of atrial lead location in cardiovascular function in the presence of impaired ventricular dysfunction is unknown. We tested the hypothesis that left atrial (LA) and left ventricular (LV) hemodynamics are affected by alterations in AV delay and are influenced by atrial pacing site in dogs with dilated cardiomyopathy. Dogs (n = 7) were chronically paced at 220 beats/min for 3 weeks to produce cardiomyopathy and then instrumented for measurement of LA, LV end diastolic pressure (LVEDP) and mean arterial pressure (MAP), LA volume, LV short-axis diameter, and aortic and pulmonary venous blood flow. Hemodynamics were measured after instrumentation and during atrial overdrive pacing from the right atrial appendage (RAA), coronary sinus ostium (CSO) and lower LA lateral wall (LAW). The AV node was then ablated, and hemodynamics were compared during dual chamber AV pacing (right ventricular apex) from each atrial lead location at several AV delays between 20 and 350 ms. Atrial overdrive pacing from different sites did not alter hemodynamics. Cardiac output (CO), stroke volume, LVEDP, MAP and +dLVP/dt demonstrated significant (P < 0.05) variation with AV delay during dual chamber pacing. CO was higher during LAW pacing than RAA and CSO pacing ( 2.3 ± 0.4 vs 2.1 ± 0.3 vs 2.0 ± 0.3 l/min , respectively) at an AV delay of 120 ms. Also, MAP was higher in the LAW than RAA and CSO ( 65 ± 9 vs 59 ± 9 vs 54 ± 11 mmHg , respectively) at an AV delay of 350 ms. Atrial lead location affects indices of LV performance independent of AV delay during dual chamber pacing in dogs with cardiomyopathy. (PACE 2003; 26[Pt. I]:853–861) 相似文献
997.
JOHN S. RUTKAUSKAS 《Periodontology 2000》2000,23(1):151-156
998.
CHARLES L. BYRD BRUCE L. WILKOFF CHARLES J. LOVE T. DUNCAN SELLERS KYONG T. TURK RUSSELL REEVES RAYMOND YOUNG BARRY CREVEY STEVEN P. KUTALEK ROGER FREEDMAN RICHARD FRIEDMAN JOEY TRANTHAM MICHAEL WATTS JOHN SCHUTZMAN JESS OREN JOHN WILSON FRANK GOLD NEAL E. FEARNOT HEIDI J. VAN ZANDT U.S. EXTRACTION DATABASE MED INSTITUTE 《Pacing and clinical electrophysiology : PACE》1999,22(9):1348-1357
Of the 400,000-500,000 permanent pacemaker leads implanted worldwide each year, around 10% may eventually fail or become infected, becoming potential candidates for removal. Intravascular techniques for removing problematic or infected leads evolved over a 5-year period (1989-1993). This article analyzes results from January 1994 through April 1996, a period during which techniques were fairly stable. Extraction of 3,540 leads from 2,338 patients was attempted at 226 centers. Indications were: infection (27%), nonfunctional or incompatible leads (25%), Accufix or Encore leads (46%), or other causes (2%). Patients were 64+/-17 years of age (range 5-96); 59% were men, 41% women. Leads were implanted 47+/-41 months (maximum 26 years), in the atrium (53%), ventricle (46%), or SVC (1%). Extraction was attempted via the implant vein using locking stylets and dilator sheaths, and/or transfemorally using snares, retrieval baskets, and sheaths. Complete removal was achieved for 93% of leads, partial for 5%, and 2% were not removed. Risk of incomplete or failed extraction increased with implant duration (P<0.0001), less experienced physicians (P<0.0001), ventricular leads (P<0.005), noninfected patients (P<0.0005), and younger patients (P<0.0001). Major complications were reported for 1.4% of patients (<1% at centers with >300 cases), minor for 1.7%. Risk of complications increased with number of leads removed (P<0.005) and with less experienced physicians (P<0.005); risk of major complications was higher for women (P<0.01). Given physician experience, appropriate precautions, and appropriate patient selection, contemporary lead removal techniques allow success with low complication rates. 相似文献
999.
Intravenous Amiodarone Suppression of Electrical Storm Refractory to Chronic Oral Amiodarone 总被引:2,自引:0,他引:2
NEAL G. KAVESH MARY R. OLSOVSKY RONALD S. FREUDENBERGER JOHN V. CONTE ROBERT W. PETERS STEPHEN R. SHOROFSKY MICHAEL R. GOLD 《Pacing and clinical electrophysiology : PACE》1999,22(4):665-667
We report the case of an electrical storm in a cardiac arrest survivor with an ICD, in whom chronic oral amiodarone failed to suppress ventricular arrhythmias, and in whom intravenous amiodarone resulted in stability for 6 weeks prior to successful cardiac transplantation. Intravenous amiodarone can be successful in suppressing life-threatening ventricular arrhythmias, even when chronic oral amiodarone is unsuccessful. 相似文献
1000.
ALEXANDRA L. TERRILL JOHN P. GAROFALO ELIZABETH SOLIDAY REBECCA CRAFT 《Journal of Applied Biobehavioral Research》2012,17(1):4-22
Coronary heart disease is the leading cause of mortality in adult women, and recent trends indicate that risk for women, particularly working mothers, has worsened during the last decade. The absence of a biological explanation for this gender discrepancy has led some to look to psychosocial risk factors. This literature review examines the effect of multiple roles on women's cardiovascular health. Further, a conceptual model of heart disease risk is proposed, which introduces background stress, a chronic stress burden, as a potential pathway between multiple roles and heart disease. Trends in the literature largely support the proposed conceptual model. Multiple roles that often place conflicting demands on women may affect health outcomes through an increase in total background stress. 相似文献