Understanding Obesity in Women

Obesity is a complex health problem and, because of the incidence of obesity in women, a common concern for providers of women's health care. For many women, obesity becomes an obsession that leads to physiologic, psychologic, and social problems. To address the needs of the obese client better, nurses must acquire a comprehensive, research-based understanding of obesity. To develop a nursing care plan, the nurse must assess the client's diet history, level of motivation to effect a change in life-style, self-image, and self-esteem.     

Cholesterol lowering therapy inhibits the low-flow mediated vasoconstriction of the brachial artery in hypercholesterolaemic subjects

1 We tested whether lipid lowering treatment with HMG CoA reductase inhibitor modified the flow mediated large artery reactivity in primary pure hypercholesterolaemia.
2 Abnormalities in arterial reactivity have been described in the presence of high blood cholesterol, in particular an enhanced constriction of the brachial artery in response to acute induction of a low flow state.
3 Using pulsed-Doppler, we measured brachial artery diameter and flow velocity at rest and their changes induced by wrist occlusion before and after 3 months of double-blind treatment by pravastatin (40  mg orally) in 13 subjects and placebo in 15 others.
4 The significant decrease ( P <0.01) in diameter induced by wrist occlusion before (0.34±0.08  mm) placebo and pravastatin (0.39±0.10  mm) persisted after placebo (0.26±0.07  mm) but was abolished after pravastatin (0.07±0.05  mm). The absolute change in diameter induced by wrist occlusion was lower after than before pravastatin ( P <0.01) and lower after pravastin than after placebo ( P <0.05). Diameter during wrist occlusion was higher after pravastatin than after placebo (4.35±0.16 vs 3.89±0.09  mm); P <0.01).
5 These findings indicate that the lipid changes induced by pravastatin and/or some unknown but direct mechanism of the drug itself inhibit low-flow-mediated vasoconstriction associated with hypercholesterolaemia. Such effects may have important implications for the treatment of vasospasm often seen in the presence of high blood cholesterol.     

The Morphological Identity of Maternal Cells in Newborn Mice

The placenta has been considered ananatomical barrier which prevents maternal rejection of the fetal allograft. Thisview is no longer tenable since, in oneparticular inbred strain of mouse, maternal blood cells have been identified bymeans of radioisotope labels in newbornmice. Both maternal red cells and lymphocytes labeled, respectively, with radiochromium and tritiated thymidinehave been detected in newborn mice.This phenomenon appears independentof the trauma of normal delivery and,what is more, occurs before term.

Submitted on February 17, 1970 Revised on April 29, 1970 Accepted on May 18, 1970     

Developmental pattern of androgen-regulated proteins in seminal vesicles from the mouse

Proteins from secretions or homogenates of mice seminal vesicles were analysed by polyacrylamide gel electrophoresis. In homogenates about 15 bands were differentially induced with molecular weights (MW's) of 12, 13, 14, 15, 15.5, 71, 120 and 140 kD, or repressed molecular weights of 12.5, 14.3, 28, 30, 53, 73, 90-105 kD). The effects of castration were reversed by testosterone and dihydrotestosterone but not by oestradiol, progesterone or corticosterone. When the androgen-dependence of proteins was investigated using radioactive methionine the protein spectra showed that about 12 bands with molecular weights of 13, 13.7, 14, 15, 15.5, 16, 20.5, 24, 37, 38.5, 56, 68, 96 and 180 kD were differentially induced or repressed by androgens. Of the induced proteins, those with low molecular weight (12-15.5 kD) were accumulated in significant amounts between 20 days and 30 days, coincident with the pubertal increase of androgens in the seminal vesicles. Those induced proteins with high molecular weight (71, 120 and 140 kD) appeared between 40 days and 60 days. The androgen-repressed proteins were strongly evident in immature males, but disappeared after day 40.     

PROLONGATION OF SUXAMETHONIUM FOLLOWING PLASMA EXCHANGE

Repeaed plasma exchange was used in the treatment of a 70-yr-oldman with Wegner's granulomatosis. Two days following the lastexchange, the plasma cholinesterase was 14% of normal and therewas a prolonged response to the action of suxamethonium.     

Sequential enumeration of peripheral blood T cell subsets in lichen planus

Peripheral blood T lymphocytes and T cell subsets were examined in fifteen patients with lichen planus prior to and for 4 months during treatment. The percentages of different T cell sub-populations were defined by indirect immunofluorescence using monoclonal antibodies OKT₃, OKT₄ and OKT₈. These are specific markers of total T cells, helper-inducer T cells and suppressor-cytotoxic T cells respectively. Decreased percentages of suppressor T cells and elevated helper suppressor ratios were observed before treatment and after 1 month of therapy. These changes had disappeared by the second month of treatment, by which time all the lesions had healed.     

Birth Control and Controlling Birth. Women-Centered Perspectives. By the same editors.

Book reviewed in this article: The Custom-Made Child? Women-Centered Perspectives . Helen B. Holmes, Betty B. Hoskins, Michael Gross, editors.