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101.
Danya Rosen Jaime Chu Rahul Patel Jang Moon Kishore Iyer Ronen Arnon 《Pediatric transplantation》2014,18(6):E193-E196
Gastric variceal bleeding is associated with high morbidity and mortality. Balloon‐occluded retrograde transvenous obliteration is a relatively new treatment used to control bleeding gastric varices that involves transvenous sclerosis of gastric varices through a spontaneous gastrorenal shunt. Here, we report on a 14‐yr‐old patient that underwent balloon‐occluded retrograde transvenous obliteration for refractory bleeding fundal varices in the setting of esophageal varices and cirrhosis, which did not respond to medical management or endoscopic injection. This case report serves as a reminder that balloon‐occluded retrograde transvenous obliteration can successfully control fundal variceal bleeding in pediatric patients and may serve as a bridge to liver transplantation. 相似文献
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Delineating developmental and metabolic pathways in vivo by expression profiling using the RIKEN set of 18,816 full-length enriched mouse cDNA arrays 下载免费PDF全文
Miki R Kadota K Bono H Mizuno Y Tomaru Y Carninci P Itoh M Shibata K Kawai J Konno H Watanabe S Sato K Tokusumi Y Kikuchi N Ishii Y Hamaguchi Y Nishizuka I Goto H Nitanda H Satomi S Yoshiki A Kusakabe M DeRisi JL Eisen MB Iyer VR Brown PO Muramatsu M Shimada H Okazaki Y Hayashizaki Y 《Proceedings of the National Academy of Sciences of the United States of America》2001,98(5):2199-2204
We have systematically characterized gene expression patterns in 49 adult and embryonic mouse tissues by using cDNA microarrays with 18,816 mouse cDNAs. Cluster analysis defined sets of genes that were expressed ubiquitously or in similar groups of tissues such as digestive organs and muscle. Clustering of expression profiles was observed in embryonic brain, postnatal cerebellum, and adult olfactory bulb, reflecting similarities in neurogenesis and remodeling. Finally, clustering genes coding for known enzymes into 78 metabolic pathways revealed a surprising coordination of expression within each pathway among different tissues. On the other hand, a more detailed examination of glycolysis revealed tissue-specific differences in profiles of key regulatory enzymes. Thus, by surveying global gene expression by using microarrays with a large number of elements, we provide insights into the commonality and diversity of pathways responsible for the development and maintenance of the mammalian body plan. 相似文献
104.
Dhanapal Jothi Sathishkumar Munusamy Selin Manoj kumar Saravanan Enbanathan Sathiyanarayanan Kulathu Iyer 《RSC advances》2022,12(14):8570
Since the cyanide ion is used in a wide range of industries and is harmful to both human health and the environment, a number of research efforts are dedicated to creating fluorescence sensors for the detection of cyanide (CN−). Herein, for the fluorescence detection of CN−, a new highly selective and sensitive sensor 2-(3-(benzo[d]thiazol-2-yl)-4-hydroxybenzylidene)-1H-indene-1,3(2H)-dione (BID) was created by conjugating a benzothiazole moiety with 1H-indene-1,3(2H)-dione. The donor and acceptor components of this hybrid receptor were covalently connected through a double bond. The nucleophilic addition of a cyanide anion to the BID inhibits the intramolecular charge transfer (ICT) transition, resulting in spectral and colour alterations in the receptor. When the solvent polarity was increased from n-hexane to methanol, this molecule exhibited a bathochromic shift in the emission wavelength (610 to 632 nm), suggesting the presence of a solvatochromic action. The sensor BID has shown strong specificity towards CN− by interrupting its internal charge transfer (ICT), resulting in a significant change in the UV-vis spectrum and a notable blue shift in the fluorescence emission spectrum. The cyanide anion (CN−) is responsible for the optical alterations observed by BID, as opposed to the other anions examined. The detection limit was 5.97 nM, significantly less than the WHO''s permitted amount of CN− in drinking water. The experimental findings indicate that BID''s fluorescence response to CN− is pH insensitive throughout a wide pH range of 6.0 to 12.0. The interaction mechanism between the BID and CN− ions has been studied by HRMS, 1H-NMR titration experiments, FT-IR, and DFT, which confirmed the nucleophilic addition of CN− on vinylidene and subsequent disturbance of ICT. Additionally, we demonstrated the real-time detection application of CN− in environmental water samples and live-cell imaging.Since the cyanide ion is used in a wide range of industries and is harmful to both human health and the environment, a number of research efforts are dedicated to creating fluorescence sensors for the detection of cyanide (CN−). 相似文献
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Caitlin V. Hall Ben J. Harrison Kartik K. Iyer Hannah S. Savage Martha Zakrzewski Lisa A. Simms Graham RadfordSmith Rosalyn J. Moran Luca Cocchi 《Human brain mapping》2022,43(2):733
There is growing recognition that the composition of the gut microbiota influences behaviour, including responses to threat. The cognitive‐interoceptive appraisal of threat‐related stimuli relies on dynamic neural computations between the anterior insular (AIC) and the dorsal anterior cingulate (dACC) cortices. If, to what extent, and how microbial consortia influence the activity of this cortical threat processing circuitry is unclear. We addressed this question by combining a threat processing task, neuroimaging, 16S rRNA profiling and computational modelling in healthy participants. Results showed interactions between high‐level ecological indices with threat‐related AIC‐dACC neural dynamics. At finer taxonomic resolutions, the abundance of Ruminococcus was differentially linked to connectivity between, and activity within the AIC and dACC during threat updating. Functional inference analysis provides a strong rationale to motivate future investigations of microbiota‐derived metabolites in the observed relationship with threat‐related brain processes. 相似文献
107.
Anagha Chawhan Ashish Athale Khalid Khan Saurabh Agarwal Rajdeep Paul Karthik Iyer Anjali Khadia Vivek Som 《Indian journal of ophthalmology》2021,69(12):3633
Purpose:To evaluate the presence of SARS-CoV-2 RNA in the conjunctival swab sample of positive confirmed COVID-19 patients and to find out its association with comorbidity and severity of COVID-19 disease.Methods:We conducted an observational cross-sectional study at a dedicated tertiary COVID-19 hospital in central India for a period of 8 weeks from February 2021to March 2021. We included patients who tested positive for SARS-CoV-2 RNA through nasopharyngeal swab and were above 18 years of age. Swab samples have been collected within 48 h of admission. Conjunctival swab was taken from the lower fornix of both eyes and sent to microbiology laboratory for real-time- polymerase chain reaction (RT-PCR).Results:Out of 150 patients, conjunctival swab RT-PCR was positive in five patients (3.33%). Two patients had conjunctival manifestations in the form of conjunctivitis but conjunctival swab RT-PCR was negative in those patients. Among the RT-PCR positive patients, two (40%) were from mild, one (20%) was from moderate, and two (40%) were from severe category. No association could be established between conjunctival swab RT-PCR positivity and severity of the disease or associated comorbidity.Conclusion:Our study provides evidence that SARS-CoV-2 RNA could be detected in conjunctival secretions, and though the risk is relatively low, the eye may act as source of transmission. Extra caution should be taken by healthcare workers, and use of proper precautions like face shields and goggles should be encouraged. 相似文献
108.
109.
Cristina Mei Joanna Fitzsimons Nicholas Allen Mario Alvarez‐Jimenez Günter Paul Amminger Vivienne Browne Mary Cannon Maryann Davis Barbara Dooley Ian B. Hickie Srividya Iyer Ein Killackey Ashok Malla Ian Manion Steve Mathias Kerryn Pennell Rosemary Purcell Debra Rickwood Swaran P. Singh Stephen J. Wood Alison Yung Patrick D. McGorry 《Early intervention in psychiatry》2020,14(1):3-13
110.
Arunaloke Chakrabarti Prashant Sood Shivaprakash M. Rudramurthy Sharon Chen Joseph Jillwin Ranganathan Iyer Ajanta Sharma Belgode Narasimha Harish Indranil Roy Anupma J. Kindo Deepinder Chhina Jayanthi Savio Deepak Mendiratta Malini R. Capoor Shukla Das Anita Arora Jagdish Chander Immaculata Xess Appalaraju Boppe Ujjwayini Ray Ratna Rao Vandana Kalwaje Eshwara Sangeeta Joshi Atul Patel Raman Sardana Anjali Shetty Umabala Pamidimukkala for the SIHAM Candidemia Network 《Mycoses》2020,63(11):1149-1163