全文获取类型
收费全文 | 650篇 |
免费 | 28篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 31篇 |
妇产科学 | 10篇 |
基础医学 | 76篇 |
口腔科学 | 17篇 |
临床医学 | 59篇 |
内科学 | 125篇 |
皮肤病学 | 27篇 |
神经病学 | 41篇 |
特种医学 | 23篇 |
外科学 | 65篇 |
综合类 | 32篇 |
预防医学 | 26篇 |
眼科学 | 1篇 |
药学 | 98篇 |
中国医学 | 16篇 |
肿瘤学 | 56篇 |
出版年
2022年 | 4篇 |
2021年 | 6篇 |
2017年 | 6篇 |
2016年 | 6篇 |
2015年 | 12篇 |
2014年 | 16篇 |
2013年 | 25篇 |
2012年 | 15篇 |
2011年 | 14篇 |
2010年 | 44篇 |
2009年 | 26篇 |
2008年 | 19篇 |
2007年 | 25篇 |
2006年 | 29篇 |
2005年 | 19篇 |
2004年 | 13篇 |
2003年 | 13篇 |
2002年 | 13篇 |
2001年 | 15篇 |
2000年 | 15篇 |
1999年 | 23篇 |
1998年 | 26篇 |
1997年 | 28篇 |
1996年 | 21篇 |
1995年 | 22篇 |
1994年 | 13篇 |
1993年 | 19篇 |
1992年 | 13篇 |
1991年 | 11篇 |
1990年 | 15篇 |
1989年 | 16篇 |
1988年 | 15篇 |
1987年 | 14篇 |
1986年 | 19篇 |
1985年 | 12篇 |
1984年 | 13篇 |
1983年 | 7篇 |
1982年 | 4篇 |
1980年 | 3篇 |
1979年 | 6篇 |
1978年 | 7篇 |
1977年 | 3篇 |
1965年 | 4篇 |
1964年 | 7篇 |
1963年 | 4篇 |
1962年 | 3篇 |
1959年 | 4篇 |
1958年 | 7篇 |
1955年 | 4篇 |
1911年 | 2篇 |
排序方式: 共有704条查询结果,搜索用时 0 毫秒
701.
Okamoto H Sasaki M Johtatsu T Kurihara M Iwakawa H Akabane M Hoshino N Yamamoto H Murata S Yamaguchi T Tani T Yamamoto A 《Journal of Clinical Biochemistry and Nutrition》2011,49(3):169-173
This study was to assess the resting energy expenditure of patients with esophageal cancer using indirect calorimetry. Eight male patients with esophageal cancer and eight male healthy controls were enrolled in this study. All patients underwent transthoracic esophagectomy with lymph nodes dissections. The resting energy expenditure was measured preoperatively, and on postoperative day 7 and 14 using indirect calorimetry. Preoperatively, the measured resting energy expenditure/body weight in these patients was significantly higher than that of the controls (23.3 ± 2.1 kcal/kg/day vs 20.4 ± 1.6 kcal/kg/day), whereas the measured/predicted energy expenditure from the Harris-Benedict equation ratio was 1.01 ± 0.09, which did not differ significantly from the control values. The measured resting energy expenditure/body weight was 27.3 ± 3.5 kcal/kg/day on postoperative day 7, and 23.7 ± 5.07 kcal/kg/day on postoperative day 14. Significant increases in the measured resting energy expenditure were observed on postoperative day 7, and the measured/predicted energy expenditure ratio was 1.17 ± 0.15. In conclusion, patients with operable esophageal cancers were almost normometabolic before surgery. On the other hand, the patients showed a hyper-metabolic status after esophagectomy. We recommended that nutritional management based on 33 kcal/body weight/day (calculated by the measured resting energy expenditure × active factor 1.2–1.3) may be optimal for patients undergoing esophagectomy. 相似文献
702.
C. W. LEES A. I. ALI A. I. THOMPSON G.-T. HO R. O. FORSYTHE L. MARQUEZ C. J. COCHRANE S. AITKEN J. FENNELL P. ROGERS† A. G. SHAND I. D. PENMAN K. R. PALMER D. C. WILSON† I. D. R. ARNOTT & J. SATSANGI 《Alimentary pharmacology & therapeutics》2009,29(3):286-297
Background Anti-TNF agents are now widely used in Crohn's disease (CD), and in ulcerative colitis (UC).
Aim To review the safety profile of anti-TNF agents in all patients treated with infliximab in Edinburgh from 1999 to 2007.
Methods Complete data were available on 202/207 patients comprising 157 CD, 42 UC and three coeliac disease. Median follow-up was 2.4 years (1.0–4.9) with a total of 620 patient-years follow-up. About 19.1% of CD patients were subsequently treated with adalimumab.
Results Seven deaths (3.3%) occurred in follow-up; only one death was <1 year post-infliximab (at day 72, from lung cancer). A total of six malignancies (three haematological, three bronchogenic) and six cases of suspected demyelination (three with confirmed neurological disease) were reported. In the 90 days following infliximab, 95 adverse events (36 serious) occurred in 58/202 (28.7%) patients. In all, 42/202 (20.8%) had an infectious event (22 serious) and 27/202 (13.4%) of patients had an infusion reaction: 19 acute (four serious) and eight delayed (three serious).
Conclusions Serious infections, malignancies and neurological disease complicate anti-TNF use in clinical practice. Although evidence for causality is unclear, potential mechanisms and predisposing factors need to be explored. In individual patients, the risk/benefit analysis needs to be carefully assessed and discussed prior to commencement of therapy. 相似文献
Aim To review the safety profile of anti-TNF agents in all patients treated with infliximab in Edinburgh from 1999 to 2007.
Methods Complete data were available on 202/207 patients comprising 157 CD, 42 UC and three coeliac disease. Median follow-up was 2.4 years (1.0–4.9) with a total of 620 patient-years follow-up. About 19.1% of CD patients were subsequently treated with adalimumab.
Results Seven deaths (3.3%) occurred in follow-up; only one death was <1 year post-infliximab (at day 72, from lung cancer). A total of six malignancies (three haematological, three bronchogenic) and six cases of suspected demyelination (three with confirmed neurological disease) were reported. In the 90 days following infliximab, 95 adverse events (36 serious) occurred in 58/202 (28.7%) patients. In all, 42/202 (20.8%) had an infectious event (22 serious) and 27/202 (13.4%) of patients had an infusion reaction: 19 acute (four serious) and eight delayed (three serious).
Conclusions Serious infections, malignancies and neurological disease complicate anti-TNF use in clinical practice. Although evidence for causality is unclear, potential mechanisms and predisposing factors need to be explored. In individual patients, the risk/benefit analysis needs to be carefully assessed and discussed prior to commencement of therapy. 相似文献
703.
The specific recognition of genomic RNAs by viral replicase proteins is a key regulatory step during the early replication process in positive-strand RNA viruses. In this study, we characterized the RNA-binding activity of the auxiliary replicase protein p27 of Red clover necrotic mosaic virus (RCNMV), which has a bipartite genome consisting of RNA1 and RNA2. Aptamer pull-down assays identified the amino acid residues of p27 involved in its specific interaction with RNA2. The RNA-binding activity of p27 correlated with its activity in recruiting RNA2 to membranes. We also identified the amino acids required for the formation of the 480-kDa replicase complex, a key player of RCNMV RNA replication. These amino acids are not involved in the functions of p27 that bind viral RNA or replicase proteins, suggesting an additional role for p27 in the assembly of the replicase complex. Our results demonstrate that p27 has multiple functions in RCNMV replication. 相似文献
704.