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991.
Samuel A. Mills Andrew I. Jobling Michael A. Dixon Bang V. Bui Kirstan A. Vessey Joanna A. Phipps Ursula Greferath Gene Venables Vickie H. Y. Wong Connie H. Y. Wong Zheng He Flora Hui James C. Young Josh Tonc Elena Ivanova Botir T. Sagdullaev Erica L. Fletcher 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(51)
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Vera Karamfilova Yavor Assyov Iveta Nedeva Antoaneta Gateva Irena Ivanova Nikolay Cherkezov Ludmila Mateva Zdravko Kamenov 《The Turkish journal of gastroenterology》2022,33(3):233
BackgroundFibroblast growth factor 21 is a peptide primarily secreted by the liver in response to peroxisome proliferator-activated receptor-α activation which plays an important role in regulating carbohydrate and lipid metabolism. This study investigated the association between fibroblast growth factor 21 and prediabetes in obese patients with non-alcoholic fatty liver disease in adult population.MethodsA total of 85 obese non-alcoholic fatty liver disease patients without (n = 49) and with prediabetes (n = 36) were included. Serum fibroblast growth factor 21 levels were determined by enzyme-linked immunosorbent assay.ResultsHigher fibroblast growth factor 21 serum levels were observed in patients with prediabetes, metabolic syndrome, dyslipidemia, and insulin resistance. There were significant correlations between fibroblast growth factor 21 and waist-to-stature ratio, visceral adiposity index, triglycerides, very low-density lipoproteins, alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), Quantitative Insulin Sensitivity Check Index, and Stumvoll index of insulin sensitivity. Fibroblast growth factor 21 level ≥320 pg/mL was associated with a 4.2-fold higher risk of prediabetes and ≥270 pg/mL for metabolic syndrome approximately 4 times.ConclusionFibroblast growth factor 21 is associated with increased risk for prediabetes, metabolic syndrome, and insulin resistance in obese patients with non-alcoholic fatty liver disease. 相似文献
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Suzanne AV Van Asten Adam Nichols Javier La Fontaine Kavita Bhavan Edgar JG Peters Lawrence A Lavery 《International wound journal》2017,14(1):40-45
In this study, we assessed the effectiveness of inflammatory markers to diagnose and monitor the treatment of osteomyelitis in the diabetic foot. We evaluated 35 consecutive patients admitted to our hospital with infected foot ulcers. Patients were divided in two groups based on the results of bone culture and histopathology: osteomyelitis and no osteomyelitis. The erythrocyte sedimentation rate (ESR), C‐reactive protein (CRP), procalcitonin (PCT), interleukin‐6 (IL‐6), interleukin‐8 (IL‐8), tumor necrosis factor alpha (TNFα), monocyte chemotactic protein‐1 (MCP‐1) and macrophage inflammatory protein‐1 alpha (MIP1α) were measured at baseline after 3 and 6 weeks of standard therapy. PCT levels in the osteomyelitis group were significantly higher at baseline than in the group with no osteomyelitis (P = 0·049). There were no significant differences between the two groups in the levels of the other markers. CRP, ESR, PCT and IL‐6 levels significantly declined in the group with osteomyelitis after starting therapy, while MCP‐1 increased (P = 0·002). TNFα and MIP1α levels were below range in 80 out of 97 samples and therefore not reported. Our results suggest that PCT might be useful to distinguish osteomyelitis in infected foot ulcers. CRP, ESR, PCT and IL‐6 are valuable when monitoring the effect of therapy. 相似文献
995.
Todorka G. Vladkova Deyan M. Monov Danail T. Akuzov Iliana A. Ivanova Dilyana Gospodinova 《Materials》2022,15(13)
No systematic study of antioxidant containing coatings and their anti-biofilm action has been reported so far. The utilization of antioxidants in protective coatings to inhibit marine biofilm formation is a current challenge. The aim of this preliminary study was to prepare, characterize and compare the efficiency of low adhesive siloxane composite coatings equally loaded with different antioxidants against mono-species biofilms formation. Most often participating in the marine biofilms formation, Marinobacter hydrocarbonoclasticus was the test bacterium. Both the biofilm covered surface area (BCSA) and corrected total cell fluorescence (CTCF) (by fluorescent microscopy) were selected as the parameters for quantification of the biofilm after 1 h and 4 h incubation. Differing extents of altered surface characteristics (physical-chemical; physical-mechanical) and the specific affection of M. hydrocarbonoclasticus biofilm formation in both reduction and stimulation, were found in the studied antioxidant containing coatings, depending on the chemical nature of the used antioxidant. It was concluded that not all antioxidants reduce mono-species biofilm formation; antioxidant chemical reactivity stipulates the formation of an altered vulcanization network of the siloxane composites and thus microbial adhesion which influences the surface characteristics of the vulcanized coatings; and low surface energy combined with a low indentation elastic modulus are probably pre-requisites of low microbial adhesion. 相似文献
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Vasiliy Y. Marchenko Ivan M. Susloparov Nataliya P. Kolosova Nataliya I. Goncharova Andrey V. Shipovalov Alexander G. Durymanov Tatyana N. Ilyicheva Lubov V. Budatsirenova Valentina K. Ivanova Georgy A. Ignatyev Svetlana N. Ershova Valeriya S. Tulyahova Valeriy N. Mikheev Alexander B. Ryzhikov 《Archives of virology》2015,160(11):2857-2860