全文获取类型
收费全文 | 855篇 |
免费 | 47篇 |
专业分类
耳鼻咽喉 | 47篇 |
儿科学 | 13篇 |
妇产科学 | 7篇 |
基础医学 | 75篇 |
口腔科学 | 5篇 |
临床医学 | 76篇 |
内科学 | 222篇 |
皮肤病学 | 11篇 |
神经病学 | 36篇 |
特种医学 | 21篇 |
外科学 | 136篇 |
综合类 | 22篇 |
预防医学 | 79篇 |
眼科学 | 9篇 |
药学 | 44篇 |
肿瘤学 | 99篇 |
出版年
2023年 | 3篇 |
2022年 | 9篇 |
2021年 | 31篇 |
2020年 | 13篇 |
2019年 | 17篇 |
2018年 | 20篇 |
2017年 | 15篇 |
2016年 | 18篇 |
2015年 | 19篇 |
2014年 | 29篇 |
2013年 | 28篇 |
2012年 | 84篇 |
2011年 | 94篇 |
2010年 | 51篇 |
2009年 | 46篇 |
2008年 | 48篇 |
2007年 | 64篇 |
2006年 | 67篇 |
2005年 | 60篇 |
2004年 | 47篇 |
2003年 | 53篇 |
2002年 | 41篇 |
2001年 | 2篇 |
2000年 | 6篇 |
1999年 | 3篇 |
1998年 | 3篇 |
1997年 | 8篇 |
1996年 | 2篇 |
1995年 | 3篇 |
1994年 | 3篇 |
1993年 | 4篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1986年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有902条查询结果,搜索用时 31 毫秒
31.
32.
Manuela Grimstein Yuching Yang Xinyuan Zhang Joseph Grillo Shiew-Mei Huang Issam Zineh Yaning Wang 《Journal of pharmaceutical sciences》2019,108(1):21-25
This commentary provides an update on the status of physiologically based pharmacokinetic modeling and simulation at the U.S. Food and Drug Administration's Office of Clinical Pharmacology. Limitations and knowledge gaps in integration of physiologically based pharmacokinetic approach to inform regulatory decision making, as well as the importance of scientific engagement with drug developers who intend to use this approach, are highlighted. 相似文献
33.
Valentina K. Todorova Stephanie D. Byrum Allen J. Gies Cade Haynie Hunter Smith Nathan S. Reyna Issam Makhoul 《Current oncology (Toronto, Ont.)》2022,29(2):613
Background: Neoadjuvant chemotherapy (NACT) is an increasingly used approach for treatment of breast cancer. The pathological complete response (pCR) is considered a good predictor of disease-specific survival. This study investigated whether circulating exosomal microRNAs could predict pCR in breast cancer patients treated with NACT. Method: Plasma samples of 20 breast cancer patients treated with NACT were collected prior to and after the first cycle. RNA sequencing was used to determine microRNA profiling. The Cancer Genome Atlas (TCGA) was used to explore the expression patterns and survivability of the candidate miRNAs, and their potential targets based on the expression levels and copy number variation (CNV) data. Results: Three miRNAs before that NACT (miR-30b, miR-328 and miR-423) predicted pCR in all of the analyzed samples. Upregulation of miR-127 correlated with pCR in triple-negative breast cancer (TNBC). After the first NACT dose, pCR was predicted by exo-miR-141, while miR-34a, exo-miR182, and exo-miR-183 predicted non-pCR. A significant correlation between the candidate miRNAs and the overall survival, subtype, and metastasis in breast cancer, suggesting their potential role as predictive biomarkers of pCR. Conclusions: If the miRNAs identified in this study are validated in a large cohort of patients, they might serve as predictive non-invasive liquid biopsy biomarkers for monitoring pCR to NACT in breast cancer. 相似文献
34.
Gaigi SS Aida M Sami J Sami M Sonia O Badis CM Hedhili O Abderraouf C Zohra M Ezeddine S Issam L Hedi R Faouzia Z Hela C Naima K 《La Tunisie médicale》2000,78(11):653-657
So, the epidemiologic study done for 8 years at CMNR Tunis has shown that the incidence is 1.15@1000 births (between 0.52 and 1.66@1000 per year). This anomaly is more frequent in female sex (sex linked = 0.59). The antenatal echographic diagnosis is efficient in 90.5%. This anomaly is more shown at low socio-economic group. The improvement of the socio-economic level and specially the daily uptake of acid folic in periconceptionnel time decrease the frequency of this congenital malformation. 相似文献
35.
Anstadt MP Schulte-Eistrup SA Motomura T Soltero ER Takano T Mikati IA Nonaka K Joglar F Nosé Y 《The Annals of thoracic surgery》2002,73(2):556-61; discussion 561-2
BACKGROUND: Direct mechanical ventricular actuation (DMVA) is a non-blood contacting method of biventricular support. DMVA employs a vacuum attached, pneumatically regulated, flexible membrane to transfer both systolic and diastolic forces to the ventricular myocardium. The purpose of this study was to determine if DMVA effectively restores pump performance when applied to the severely failing heart. METHODS: Bovines (n = 10) underwent thoracotomy and were instrumented for continuous hemodynamic monitoring. Cardiac failure was induced by beta1-blockade to achieve a cardiac index of < 1.5 l/min/m2 for 1 hour. Heart rate was maintained at 100 bpm by atrioventricular sequential pacing. Synchronous DMVA support was then applied for 3 hours. RESULTS: Eight animals achieved significant reductions in cardiac index and mean arterial pressures (35%* and 43%* control, respectively; *p < 0.05). DMVA restored cardiac index to baseline and significantly increased arterial pressures (p < 0.05; DMVA versus cardiac failure). Pulmonary flow and mean pulmonary artery pressures were similar to baseline during DMVA (p = NS). Pathologic exam did not demonstrate evidence of significant device trauma. CONCLUSIONS: DMVA support can effectively restore pump performance of the acutely failing heart. Synchronization may be inherent to the stimulus of cardiac compression. These data further substantiate DMVA's potential as an adjunct to the field of circulatory support. 相似文献
36.
The anterior hernia or the fissure of Larrey and Bochdalek hernia are exceptional in adult. We present 6 cases of congenital diaphragmatic hernia revealed in adult. Three hernia of the fissure of Larrey and three Bochdalek hernia. We discuss the different clinical, radiological, and therapeutic aspects of these hernia. We insist on the gravity of strangulated hernia and their surgical treatment. 相似文献
37.
38.
39.
40.