全文获取类型
收费全文 | 2266篇 |
免费 | 143篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 57篇 |
妇产科学 | 54篇 |
基础医学 | 314篇 |
口腔科学 | 79篇 |
临床医学 | 205篇 |
内科学 | 425篇 |
皮肤病学 | 20篇 |
神经病学 | 304篇 |
特种医学 | 46篇 |
外国民族医学 | 1篇 |
外科学 | 359篇 |
综合类 | 24篇 |
预防医学 | 231篇 |
眼科学 | 45篇 |
药学 | 136篇 |
中国医学 | 12篇 |
肿瘤学 | 100篇 |
出版年
2023年 | 17篇 |
2022年 | 19篇 |
2021年 | 46篇 |
2020年 | 33篇 |
2019年 | 52篇 |
2018年 | 54篇 |
2017年 | 43篇 |
2016年 | 50篇 |
2015年 | 59篇 |
2014年 | 76篇 |
2013年 | 111篇 |
2012年 | 128篇 |
2011年 | 134篇 |
2010年 | 70篇 |
2009年 | 66篇 |
2008年 | 127篇 |
2007年 | 127篇 |
2006年 | 124篇 |
2005年 | 108篇 |
2004年 | 114篇 |
2003年 | 82篇 |
2002年 | 107篇 |
2001年 | 82篇 |
2000年 | 60篇 |
1999年 | 55篇 |
1998年 | 22篇 |
1997年 | 20篇 |
1996年 | 22篇 |
1995年 | 17篇 |
1994年 | 12篇 |
1993年 | 23篇 |
1992年 | 41篇 |
1991年 | 32篇 |
1990年 | 36篇 |
1989年 | 37篇 |
1988年 | 31篇 |
1987年 | 19篇 |
1986年 | 20篇 |
1985年 | 22篇 |
1984年 | 15篇 |
1983年 | 9篇 |
1979年 | 6篇 |
1978年 | 13篇 |
1977年 | 12篇 |
1975年 | 8篇 |
1974年 | 7篇 |
1973年 | 5篇 |
1972年 | 8篇 |
1971年 | 5篇 |
1970年 | 8篇 |
排序方式: 共有2421条查询结果,搜索用时 897 毫秒
41.
Richard C Palmer Maria E Fernandez Guillermo Tortolero-Luna Alicia Gonzales Patricia Dolan Mullen 《Health education & behavior》2005,32(4):488-503
Factors contributing to the underuse of mammography screening by female Hispanic farmworkers aged 50 years and older in the Lower Rio Grande Valley were determined through home-based, Spanish-language personal interviews (N = 200). Questions covered adherence to screening mammography guidelines (mammogram within 2 years), healthcare access, sociodemographic characteristics, and theoretical constructs related to breast cancer screening in the literature. Multivariate findings indicated that adherent women were 3.6 times more likely to have health insurance. Self-efficacy for obtaining a mammogram and decisional balance were also significantly related to adherence; age, income, and education variables were not associated, perhaps because of restricted variation. Results indicate continuing efforts are needed to ensure that medically underserved migrant farmworker women have access to health care services. In addition, efforts to increase their self-efficacy in obtaining a mammogram and to counter negative attitudes and opinions by stressing the positive prognosis associated with early detection are warranted. 相似文献
42.
Fass U Panickar K Personett D Bryan D Williams K Gonzales J Sugaya K McKinney M 《Neuroreport》2000,11(5):931-936
Many neuronal nitric oxide synthase (nNOS)-expressing brain neurons, including some cholinergic populations, are resistant to disease or to certain forms of excitotoxicity. Vulnerability to NO excess of forebrain (medial septal/diagonal band; MS-ACh) and brainstem (pedunculopontine/laterodorsal tegmental nuclei; BS-ACh) cholinergic neurons was compared in E16-E18 primary rat brain cultures. MS-ACh cells were approximately 300-fold more sensitive to the NO donor S-nitro-N-acetyl-D,L-penicillamine (SNAP) than were BS-ACh cells. Most (69%) MS-ACh cells contained nuclear DNA fragments by 2 h after addition of SNAP, while only 21% BS-ACh cells were TUNEL-positive after NO excess. Depletion of glutathione content did not potentiate the effect of SNAP on MS-ACh cells, but sensitized BS-ACh cells to the NO donor. Caffeic acid, a putative NF-kappa B inhibitor, enhanced the toxicity of SNAP to cholinergic neurons in both preparations. Our experiments show that cholinergic neurons in mixed primary cultures from different brain regions possess biochemical differences with respect to their vulnerability to NO excess. 相似文献
43.
F. Wei M. H. Van Horn M. C. Coombs X. She T. S. Gonzales Y. M. Gonzalez J. M. Scott L. R. Iwasaki J. C. Nickel H. Yao 《Journal of oral rehabilitation》2017,44(7):517-525
Temporomandibular disorder (TMD) incidences are believed to be related to parafunctional behaviours like teeth clenching. This pilot study aimed to (i) develop an automated clench‐detection algorithm, and (ii) apply the algorithm to test for differences in nocturnal clenching in women with and without TMD. Subjects gave informed consent to participate. Adult women were categorised using Diagnostic Criteria for TMD according to presence/absence (+/?) of both TM joint disc placement (DD) and chronic pain (P) into two groups (+DD+P, ?DD?P) with 12 subjects each. Surface temporalis electromyography was recorded during oral tasks performed by subjects at two laboratory sessions. The data were used to characterise muscle activity per N of bite force (μV/N) for each subject, develop the clench‐detection algorithm and test its accuracy. Ambulatory surface temporalis electromyography was self‐recorded by each subject over three nights and analysed using the algorithm and bite force (N) versus muscle activity μV/N calibrations. Bonferroni‐adjusted homoscedastic t‐tests assessed for significant between‐group differences in clenching (P < 0·05). Sensitivity, specificity and accuracy of algorithm‐detected laboratory clenches were all ≥96%. During self‐recordings 95% of clenches had durations of <4 s and peak forces of <10 N in both groups. Mean clench durations were significantly longer (P = 0·042) in +DD+P (1·9 ± 0·8 s) than ?DD?P subjects (1·4 ± 0·4 s). Mean temporalis duty factors (%clench time/total recording time) were significantly larger (P = 0·041) in +DD+P (0·47 ± 0·34%) than ?DD?P (0·26 ±0·22%) subjects. Nocturnal temporalis muscle activities detected by a validated algorithm were longer per clench and recording time in +DD+P compared to ?DD?P women. 相似文献
44.
45.
46.
47.
48.
Luis Felipe Casado José Ángel Hernández Isidro Jarque María Echave Miguel Angel Casado Antonio Castro 《European journal of haematology》2018,100(3):264-272
Objective
To evaluate the incremental cost‐utility ratio (ICUR) of idelalisib in combination with rituximab (IR) versus rituximab monotherapy (R) in the treatment of patients with relapsed or refractory (R/R) chronic lymphocytic leukaemia (CLL), from the Spanish National Health System (NHS) perspective.Methods
A partitioned survival Markov model for a lifetime horizon (30 years) was developed to estimate costs (€, 2016) and quality‐adjusted life years (QALY) with IR and R. Initial cohort included patients with CLL receiving a second or subsequent line (2L) of treatment with IR or R. Survival data were based on CLL clinical trial. Drug, administration, monitoring, adverse events and clinical management of CLL costs were included in the model. Costs and outcomes were discounted using a 3% annually. Deterministic and probabilistic sensitivity analyses (PSA) were performed.Results
Compared to R, 2L IR treatment resulted in QALY gain of 3.147 (4.965 versus 1.818). Total costs were €118 254 for IR versus €23 874 for R. ICUR was €29 990/QALY gained with IR versus R. In the PSA, IR was cost‐effective in 78% of iterations using a threshold of €45 000/QALY.Conclusion
IR can be considered a cost‐effective treatment compared to R, in the treatment of R/R CLL patients for the Spanish NHS. 相似文献49.
50.