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991.
Human endometriosis is associated with plasma cells and overexpression of B lymphocyte stimulator 总被引:2,自引:0,他引:2
992.
993.
Araya AV Rojas P Fritsch R Rojas R Herrera L Rojas G Gatica H Silva H Fiedler JL 《Endocrine》2006,30(3):289-297
A link between stressful life events and development or exacerbation of depression has been established via a large body of
evidence. An alteration in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis in depression has also been associated
with an increase in cortisol secretion. As arginine-vasopressin (AVP) plays an important role in the activation of HPA axis
during stress, the present study investigated ACTH and cortisol secretory response induced by an AVP-related with the clinical
response to venlafaxine treatment, which offers a dual antidepressant action. Depressive patients with no other psychiatric
pathology were evaluated with 17-item Hamilton Depression Scale (HAMD) in order to follow-up the response to venlafaxine.
After 1 wk of treatment, 60% of patients reduced their initial HAM-D score to at least 25%; this group was classified as early
responders. The other group (40%) started to reduce significantly their HAM-D score after 3 wk of treatment and was classified
as late responders. After 6 wk of treatment both groups have reduced HAM-D score to at least 25% of the baseline score. Prior
to the pharmacological treatment, both early and late responders showed salivary cortisol rhythm and urinary free cortisol
(UFC) in 24-h similar to healthy subjects. However, we did observe differences in basal ACTH secretion, showing that the late
responder group had higher basal ACTH than both early responders and controls. The ddAVP challenge promoted a robust secretion
of ACTH only in late responders, suggesting a different sensitivity of pituitary vasopressin receptor. The differences in
clinical response to venlafaxine among depressive patients seem to be related to endocrinological parameters. 相似文献
994.
Yuri Jang David A. Chiriboga Julio R. Herrera Laurence G. Branch 《Journal of cross-cultural gerontology》2009,24(2):181-191
This study examined the prevalence of self-reported ‘poor health’ among Cuban elders in Havana (n = 1,183) and Miami (n = 288) and explored the roles of chronic conditions and functional disability in their self-reports. A logistic regression
model of reported poor health was estimated for each group, testing both independent and interactive effects of chronic conditions
and functional disability. Despite differences in sociodemographic characteristics and disease/disability profiles between
Cuban elders in the two cities, an equal proportion of each group (13%) reported poor health. Financial strain and functional
disability were common predictors of self-reported poor health across the groups. Gender and chronic conditions were significant
only in the Havana sample, among whom the likelihood of reporting poor health increased with female gender and the presence
of chronic conditions. In the Havana sample, not only did chronic conditions have an independent effect, but also its interaction
with functional disability was significant. The overall results suggest a particular role of chronic conditions in determining
subjective health among elders in Havana. Findings are discussed in a sociocultural context. 相似文献
995.
Rodríguez L Cuadrado Pérez I Herrera Montes J Lorente Jareño ML López Grondona F Martínez-Frías ML 《American journal of medical genetics》2002,110(1):73-77
We report on a new patient with a 7q terminal deletion. The 18-month-old boy had metal retardation, microcephaly, a distinctive face, bilateral coloboma, café-au-lait spot on the abdomen, and sacral agenesis. The high resolution GTG bands (550-850 bands), currently used in our laboratory, showed a 7q terminal deletion, which was also confirmed with fluorescence in situ hybridization (FISH). The homeobox HLXB9 gene, localized at 7q36 has been demonstrated to be involved in sacral agenesis; in fact patients with 7q terminal deletions frequently have this malformation. We could not perform molecular studies in this patient to confirm the HLXB9 haploinsufficiency, but we postulate that he carried it. 相似文献
996.
Catia Simoes Sara Villar Beñat Ariceta Juan-José Garcés Leire Burgos Diego Alignani Sarai Sarvide David Martínez-Cuadrón Juan-Miguel Bergua Susana Vives Lorenzo Algarra Mar Tormo Pilar Martinez Josefina Serrano Pilar Herrera Fernando Ramos Olga Salamero Esperanza Lavilla Cristina Gil Jose-Luis Lopez-Lorenzo Maria-Belen Vidriales Carmen Chillon Jorge Labrador Jose-Francisco Falantes María-José Sayas Rosa Ayala Joaquin Martinez-Lopez Ana Alfonso Pierola Maria-Jose Calasanz Felipe Prosper Jesús F. San-Miguel Miguel Á. Sanz Bruno Paiva Pau Montesinos the PETHEMA cooperative study group 《British journal of haematology》2023,201(6):1239-1244
997.
Wynne E. Moss M. Zachariah Peery Gustavo A. Gutiérrez-Espeleta Christopher Vaughan Geovanny Herrera Jonathan N. Pauli 《Conservation Genetics Resources》2012,4(4):1037-1039
The brown-throated three-toed sloth (Bradypus variegatus) is an extremely sedentary arboreal mammal found in many Neotropical forests. Because of its low dispersal potential and ease in capture, it has the potential to serve as a model species to investigate the effects of land cover change in the Neotropics on gene flow and population connectivity. To better understand aspects of B. variegatus biology, such as mating system and dispersal rates, we isolated and characterized 18 polymorphic microsatellite markers. Markers were tested using 32 B. variegatus individuals sampled from a site in northeastern Costa Rica. Each locus contained between three and 12 alleles, while mean expected and observed heterozygosity were equal to 0.72. No loci deviated from Hardy?CWeinberg equilibrium, and one locus was significantly linked to two others. These markers have sufficient polymorphism to identify individuals and assign parentage, and can further be used to investigate dispersal rates, mating structure, and other aspects of three-toed sloth ecology. 相似文献
998.
999.
Selene Pérez-García Mar Carrión Rebeca Jimeno Ana M. Ortiz Isidoro González-Álvaro Julián Fernández Rosa P. Gomariz Yasmina Juarranz 《Journal of molecular neuroscience : MN》2014,52(1):18-27
Plasminogen activators are specific proteolytic enzymes implicated in a variety of basic biological processes. The expression of the urokinase plasminogen activator system components is increased in some human diseases, including osteoarthritis. We sought to study the effect of two components of the inflamed synovial microenvironment on this system, IL-1β and fibronectin fragments, elucidating whether corticotropin-releasing factor (CRF) and vasoactive intestinal peptide (VIP) neuropeptides modulate it, and analyzing the physiological consequences in joint destruction by measuring matrix metalloproteinases-9 and metalloproteinases-13 levels in osteoarthritis fibroblast-like synoviocytes. We showed that IL-1β and fibronectin fragments stimulated urokinase system contributing to the perpetuation of the destructive cascade in joint. VIP modulated, even at constitutive level, this system, also counteracting the effect of both inflammatory stimuli. However, CRF seemed to be ineffective in controlling the production of these proteinases. Moreover, VIP was able to reduce the constitutive expression of matrix metalloproteinase-13 and the levels of both matrix metalloproteinases after stimulation with the pro-inflammatory stimuli. Our results suggest that the presence of early and later inflammatory mediators, such as IL-1β and fibronectin fragments, increases the urokinase system and the matrix metalloproteinases levels. Whereas CRF did not affect this system, VIP counteracts these actions supporting its therapeutic potential for the treatment of osteoarthritis. 相似文献
1000.
Lilian Málaga-Figueroa Marco Antonio Alarcón Claudio Mendes Pannuti Patricia Horna Andrea López-Pacheco Mariel Gómez Paola Jiménez Giuseppe Alexandre Romito Elizabeth Lozano Andrés Duque Mauricio Montealegre Marco Vinicio Medina Vega Roberto Galindo Vilma Umanzor Agustín Zerón Carlos Barrios Mónica Shedden Ruth Castillo James Collins Luis Bueno Xiomara Giménez Mariano Sanz David Herrera 《Journal of periodontal research》2024,59(2):237-248