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991.
992.
Abe Y Okazaki Y Hiasa K Hirata I Yoshida Y Taji T Suzuki K Okazaki M Akagawa Y 《Dental materials journal》2010,29(6):668-672
The purpose of this study was to characterize the chemical interaction between titanium surfaces and the peptide RGDS(PO(3)H(2))PA (P-RGD) synthesized from RGD peptide (RGD) and o-phospho-L-serine (P-Ser), and to determine the degree of peptide immobilization on the titanium surface. X-ray photoelectron spectroscopy showed that the adsorption amount of RGD was significantly smaller than those of P-Ser and P-RGD (p<0.05). Furthermore, although it appeared that P-RGD bonded to the surface, ultrasonic rinsing with water caused it to dissociate, releasing RGD and leaving only S(PO(3)H(2))PA bonded to the surface. These findings show that although it remains difficult to obtain a stable P-RGD layer, the phosphate functional group greatly improves immobilization of the molecule on titanium surfaces. 相似文献
993.
994.
995.
Koyama A Ito H Nakanishi M Sawamura K Higuchi T 《Psychiatry and clinical neurosciences》2008,62(1):56-64
Aims: The objective of the present study was to identify schizophrenia inpatients who had their original regimen augmented with additional antipsychotics during acute inpatient care, and to clarify the factors associated with these additions.
Methods: The subjects were 204 schizophrenia inpatients at 34 acute care hospitals, of whom 42 (20.6%) had further antipsychotics added to their medication regimen during hospitalization.
Results: Compared with patients who were not prescribed additional antipsychotics, the subjects were typically discharged with higher dosages of antipsychotics, principally low-potency medications. Patients who exhibited aggressive behavior, who had no physical illness, or whose psychiatrists preferred typical antipsychotics, were more likely to be prescribed additional new antipsychotics.
Conclusions: Alternative approaches such as intensive care for aggressive patients and educational intervention with psychiatrists may prove useful in stabilizing patients without adding new antipsychotics unless absolutely necessary, and in simplifying medication regimens. 相似文献
Methods: The subjects were 204 schizophrenia inpatients at 34 acute care hospitals, of whom 42 (20.6%) had further antipsychotics added to their medication regimen during hospitalization.
Results: Compared with patients who were not prescribed additional antipsychotics, the subjects were typically discharged with higher dosages of antipsychotics, principally low-potency medications. Patients who exhibited aggressive behavior, who had no physical illness, or whose psychiatrists preferred typical antipsychotics, were more likely to be prescribed additional new antipsychotics.
Conclusions: Alternative approaches such as intensive care for aggressive patients and educational intervention with psychiatrists may prove useful in stabilizing patients without adding new antipsychotics unless absolutely necessary, and in simplifying medication regimens. 相似文献
996.
997.
Nozaki I Kubo Y Kurita A Tanada M Yokoyama N Takiyama W Takashima S 《Surgical endoscopy》2008,22(12):2665-2669
Background Laparoscopic wedge resection (LWR) can be applied for the management of early gastric cancer without the risk of lymph node
metastasis. Although LWR for early gastric cancer is one of the minimally invasive procedures, its radicality in cancer therapy
is controversial. This study aimed to evaluate the long-term outcomes after LWR.
Methods Data on 43 consecutive cases of LWR performed for preoperatively diagnosed mucosal gastric cancer were analyzed retrospectively
in terms of long-term outcomes.
Results No postoperative deaths occurred after LWR. Histologically, resected specimens showed submucosal invasion in 11 cases (26%)
and positive surgical margins for cancer in 4 cases (9%). Three patients (7%) showed local recurrence near the staple line,
and one patient (2%) died due to the local recurrence, but no lesional lymph node or distant recurrence occurred. The overall
5-year survival rate was 88%. The gastric remnant after LWR developed metachronous multiple gastric cancer in five cases (12%).
Conclusions The findings show a relatively high incidence of positive surgical margin, local recurrence, and gastric remnant cancer after
LWR. Although LWR can be performed for properly selected patients, periodic postoperative endoscopic examination is necessary
to detect metachronous multiple gastric cancer and local recurrences. 相似文献
998.
Yoshikawa N Nakanishi K Ishikura K Hataya H Iijima K Honda M;Japanese Pediatric IgA Nephropathy Treatment Study Group 《Pediatric nephrology (Berlin, Germany)》2008,23(5):757-763
In two previous randomized controlled trials we showed that treatment of severe childhood immunoglobulin A nephropathy (IgA-N)
using prednisolone, azathioprine, heparin–warfarin, and dipyridamole prevented any increase of sclerosed glomeruli and that
prednisolone alone did not prevent a further increase of sclerosed glomeruli. Accordingly, the immunosuppressant is considered
to be important. Often, however, we were unable to complete azathioprine regimen due to toxicity. Therefore, a different but
effective immunosuppressant may be worth trying. Mizoribine, like azathioprine, is an antimetabolite that exerts its immunosuppressant
effect by inhibiting lymphocyte proliferation. In this pilot study, we administered mizoribine instead of azathioprine as
part of the combination therapy for treating 23 children with severe IgA-N and evaluated the efficacy and safety. Eighteen
patients reached the primary endpoint (urine protein/creatinine ratio <0.2) during the 2-year treatment period. The cumulative
disappearance rate of proteinuria determined by Kaplan–Meier was 80.4%. Median protein excretion was reduced from 1.19 g/m2/day to 0.05 g/m2/day (p < 0.0001). After treatment, the median percentage of glomeruli showing sclerosis was unchanged in comparison with that before
treatment. No patients required a change of treatment. In conclusion, the efficacy and safety of the mizoribine combination
seems to be acceptable for treating children with severe IgA-N.
*Participants listed at end of paper. 相似文献
999.
Idetsu A Ojima H Saito K Hirayama I Hosouchi Y Nishida Y Nakajima T Kuwano H 《Surgery today》2008,38(1):68-71
A lymphoepithelial cyst (LEC) is an extremely rare benign lesion of the pancreas. During a medical check-up, a 77-year-old
man without any symptoms was found to have a cyst in the body of the pancreas. His serum carbohydrate antigen 19-9 level was
slightly elevated. Computed tomography showed a multilocular, low-attenuating cyst on the superior surface of the pancreatic
body. Thus, we performed distal pancreatectomy with splenectomy. Histological examination revealed that the cyst wall was
lined with squamous epithelium and surrounded by abundant mature lymphoid tissue. Keratinous substances were present in the
cyst. An LEC of the pancreas is associated with a good prognosis and, although unusual, it should be considered in the differential
diagnosis of pancreatic cystic lesions. Minimal resection of the cyst should be performed whenever possible, and extensive
surgery avoided. For patients with a high surgical risk, fine-needle aspiration biopsy may be considered. 相似文献
1000.
A lobectomy with a resection of the pulmonary artery is less invasive than a pneumonectomy. However, it seems to be extremely difficult to perform this technique using video-assisted thoracic surgery with technical limitations because this technique is associated with an increased operative risk even in an open thoracotomy. Between April 2002 and December 2006, a curative video-assisted thoracic surgery lobectomy including a mediastinal lymphadenectomy was performed in 121 patients with primary non-small cell lung cancer. Five of those patients underwent a thoracoscopic lobectomy with the partial removal and reconstruction of the pulmonary artery. The causes of the pulmonary artery resection included two direct invasions of the artery, two invasions of the arterial branch, and one calcified lymphadenopathy involving the branch. No patients required a blood transfusion. No complications attributable to the technique or mortality were seen. No patients showed an abnormal blood flow through the reconstructed vessel. There were no local recurrences on the pulmonary artery. A video-assisted thoracic surgery lobectomy including a partial resection and reconstruction of the pulmonary artery is a complex procedure for patients with non-small cell lung cancer. It is feasible when all associated technical issues are properly addressed. 相似文献