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151.
Impact of platelet transfusion on toxicity and mortality after hematopoietic progenitor cell transplantation 下载免费PDF全文
Grace Christou Natasha Kekre William Petrcich Melanie Tokessy Doris Neurath Antonio Giulivi Elianna Saidenberg Sheryl McDiarmid Harold Atkins Isabelle Bence‐Bruckler Christopher Bredeson Lothar Huebsch Mitchell Sabloff Dawn Sheppard Jason Tay Alan Tinmouth David S. Allan 《Transfusion》2015,55(2):253-258
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Krishna B. Clough MD Djazia Benyahi MD Claude Nos MD Caroline Charles PhD Isabelle Sarfati MD 《The breast journal》2015,21(2):140-146
In recent decades, the surgical management of breast cancer has steadily and considerably improved. Mutilating procedures have given way to more individualized surgical approaches aiming to preserve the breast as much as possible. For large tumors, preoperative chemotherapy is a major tool, but emerging oncoplastic surgery techniques are also a new approach in the armamentarium of breast cancer surgery, as a third option between conventional breast‐conserving surgery and mastectomy. As this new treatment modality allows wider margin excision, it reduces the need for re‐excision procedures and possibly increases breast conservation rates by extending the indications of breast‐conserving surgery. This review will provide an overview of current practices and clinical data available to date on oncoplastic surgery. 相似文献
155.
Zhen EY Brittain IJ Laska DA Mitchell PG Sumer EU Karsdal MA Duffin KL 《Arthritis and rheumatism》2008,58(8):2420-2431
OBJECTIVE: To identify, characterize, and compare proteolysis peptide products generated by metalloprotease digests of human articular cartilage. METHODS: Human articular cartilage was digested by the addition of exogenous metalloproteases, including matrix metalloproteinases 2, 3, 8, 9, 12, and 13 and aggrecanases ADAMTS-4 and ADAMTS-5. Proteolyzed peptide products were identified by proteomics methods using mass spectrometry. RESULTS: Complete sequences of the peptides proteolyzed from human articular cartilage, including N- and C-termini and hydroxylated posttranslational modifications, were determined. A wide variety of peptides, originating from types I, II, and III collagen, biglycan, prolargin, fibromodulin, fibronectin, decorin, cartilage oligomeric matrix protein, cartilage intermediate-layer protein, megakaryocyte-stimulating factor, mimecan, aggrecan, and lumican, was analyzed following metalloprotease digestion. Release of peptides varied as a function of time, enzyme specificity, and abundance. Specific type II collagen peptide biomarkers, including those containing the three-quarter-length fragment cleavage site and those containing the domains for helical peptide of type II collagen and C-telopeptide of type II collagen, were observed after release by selected proteases. CONCLUSION: The use of intact cartilage instead of purified protein substrates in the assay allowed for the identification of novel potential substrates and cleavage sites for individual enzymes under more physiologically relevant conditions. Characterization of these cartilage matrix peptides may help in the development of pharmacodynamic biomarkers of cartilage degradation, and also may contribute to an understanding of the bioactive peptides important in chondrocyte signaling. 相似文献
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L'Huillier I Cottin Y Touzery C Zeller M Beel JC Fraison M Verges B Louis P Brunotte F Wolf JE 《International journal of cardiology》2003,90(2-3):165-173
Objective: This study was designed to assess the prognostic value of myocardial tomoscintigraphy perfusion imaging after percutaneous coronary intervention (PCI) in asymptomatic diabetic patients. Methods: One hundred and fourteen diabetic patients were followed up during 27±16 (mean±SD) months after the myocardial tomoscintigraphy. PCI-related events were studied after myocardial tomoscintigraphy stress testing and included major cardiac events (MACE) (cardiovascular death, myocardial infarction) and revascularization (bypass surgery or new PCI). Stress myocardial tomoscintigraphy imaging was performed 5±5 months after PCI and ischemia was considered as present if at least 2 contiguous segments were showing reversible defects. Results: Persistent silent ischemia was found in 49/114 (43%) patients. No difference was observed between the two groups for MACE: four among the 65 (6%) non ischemic patients versus 2 among the 49 (4%) ischemic patients (NS). In contrast, 15 (31%) among the ischemic patients and 4 (6%) among the non ischemic patients underwent iterative revascularization (p<0.01). The relative risk of revascularization for patients with significant ischemia was 5.5 versus non ischemic patients (p<0.001). Conclusion: After PCI, in asymptomatic diabetic patients followed by myocardial tomoscintigraphy a high frequency of persistent silent ischemia was found and associated with a high risk for repeat interventional procedure, although no increase in major cardiac events was observed. 相似文献
158.
Barriers and facilitators to recruitment in mental health services: Care coordinators' expectations and experience of referring to a psychosis research trial 下载免费PDF全文
159.
Prevalence of Giant Cell Arteritis Relapse in Patients Treated With Glucocorticoids: A Meta‐Analysis
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