全文获取类型
收费全文 | 328篇 |
免费 | 34篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 11篇 |
妇产科学 | 16篇 |
基础医学 | 55篇 |
口腔科学 | 6篇 |
临床医学 | 37篇 |
内科学 | 60篇 |
皮肤病学 | 7篇 |
神经病学 | 36篇 |
特种医学 | 10篇 |
外科学 | 43篇 |
综合类 | 1篇 |
预防医学 | 17篇 |
眼科学 | 2篇 |
药学 | 10篇 |
中国医学 | 1篇 |
肿瘤学 | 49篇 |
出版年
2024年 | 1篇 |
2023年 | 11篇 |
2022年 | 11篇 |
2021年 | 20篇 |
2020年 | 12篇 |
2019年 | 9篇 |
2018年 | 14篇 |
2017年 | 10篇 |
2016年 | 13篇 |
2015年 | 13篇 |
2014年 | 25篇 |
2013年 | 17篇 |
2012年 | 26篇 |
2011年 | 23篇 |
2010年 | 15篇 |
2009年 | 9篇 |
2008年 | 14篇 |
2007年 | 15篇 |
2006年 | 17篇 |
2005年 | 10篇 |
2004年 | 14篇 |
2003年 | 14篇 |
2002年 | 14篇 |
2001年 | 3篇 |
2000年 | 3篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1997年 | 6篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1983年 | 1篇 |
1981年 | 2篇 |
1977年 | 2篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1969年 | 3篇 |
1967年 | 1篇 |
排序方式: 共有363条查询结果,搜索用时 15 毫秒
351.
Becker E Dee V Gawlinski A Kirkpatrick T Lawanson-Nichols M Lee B Marino C McNair N Melwak MA Purdy I Samimi SS Sund G Zanotti J 《Clinical nurse specialist CNS》2012,26(2):74-86
In the practice of nursing, organizations with progressive evidence-based practice programs implement structures and processes whereby nurses are engaged in the review of existing research and in the development of clinical practice documents to better align nursing practices with the best available scientific knowledge. At our academic hospital system, clinical nurse specialists (CNSs) took the lead to help transform a traditional nursing policy and procedure committee into a hospital-wide, staff-represented Clinical Practice Council (CPC) that ensures evidence-based nursing practices are reflected in the organization's nursing practice documents for the provision of patient care. Clinical nurse specialists function as mentors and cochairs who are dedicated to ensuring that nursing practice is supported by the latest evidence and committed to guiding staff nurses to continually move their practice forward. The success of the CPC is due to the leadership and commitment of the CNSs. This article describes the structure, process, and outcomes of an effective CPC where CNSs successfully engage frontline clinicians in promoting nursing care that is evidence based. Clinical nurse specialist leadership is increasingly made visible as CNSs effectively involve staff nurses in practice reforms to improve patient outcomes. 相似文献
352.
Schröder C Witzel I Müller V Krenkel S Wirtz RM Jänicke F Schumacher U Milde-Langosch K 《Journal of cancer research and clinical oncology》2011,137(8):1193-1201
Purpose
The intercellular adhesion molecule (ICAM)-1 is expressed on many cell types including endothelial cells and different cancer cell entities. Experimental data strongly indicate that ICAM-1 can activate intracellular signalling pathways in cancer cells leading to enhanced cell motility, invasion and metastasis. Yet, little is known about the role of ICAM-1 expression during malignant progression in breast cancer patients. 相似文献353.
354.
355.
Tanja N. Fehm Manfred Welslau Volkmar Müller Diana Lüftner Florian Schütz Peter A. Fasching Wolfgang Janni Christoph Thomssen Isabell Witzel Erik Belleville Michael Untch Marc Thill Hans Tesch Nina Ditsch Michael P. Lux Bahriye Aktas Maggie Banys-Paluchowski Andreas Schneeweiss Cornelia Kolberg-Liedtke Andreas D. Hartkopf Achim Wckel Hans-Christian Kolberg Nadia Harbeck Elmar Stickeler 《Geburtshilfe und Frauenheilkunde》2022,82(9):912
This review summarizes recent developments in the prevention and treatment of patients with early-stage breast cancer. The individual disease risk for different molecular subtypes was investigated in a large epidemiological study. With regard to treatment, new data are available from long-term follow-up of the Aphinity study, as well as new data on neoadjuvant therapy with atezolizumab in HER2-positive patients. Biomarkers, such as residual cancer burden, were investigated in the context of pembrolizumab therapy. A Genomic Grade Index study in elderly patients is one of a group of studies investigating the use of modern multigene tests to identify patients with an excellent prognosis in whom chemotherapy may be avoided. These and other aspects of the latest developments in the diagnosis and treatment of breast cancer are described in this review.Key words: breast cancer, early stage, adjuvant treatment, neoadjuvant treatment, chemotherapy, endocrine therapy 相似文献
356.
357.
Isabell M. Meier Estrella R. Montoya Hannah Spencer Sofia C. Orellana Mariët van Buuren Jack van Honk Peter A. Bos 《Developmental psychobiology》2023,65(1):e22349
Sensitivity for rewarding cues and distress signals from children is fundamental to human caregiving and modulated by the neuropeptide oxytocin. In a functional magnetic resonance imaging study, we investigated whether oxytocin regulates neural responses to reward or distress cues form children. In a placebo-controlled, within-subject design, we measured neural responses to positive, negative, and neutral cues from children in 22 healthy female subjects who received oxytocin (24 IU) versus placebo. Further, based on current literature, we hypothesized that oxytocin effects are modulated by experiences of childhood trauma. The task elicited valence-specific effects—positive images activated the ventromedial prefrontal cortex, left anterior cingulate cortex, and right putamen, and images of children in distress activated the bilateral amygdala, hippocampus, and right medial superior frontal cortex. The effects of oxytocin depended on subjective reports of childhood emotional neglect. Self-reported neglect interacted with oxytocin administration in the amygdala, hippocampus, and prefrontal areas. In individuals with higher scores of emotional neglect, oxytocin increased neural reactivity of limbic structures to positive and neutral images. Our findings need replication in larger samples and can therefore be considered preliminary but are in line with the recent literature on the modulating effect of childhood adversity on the sensitivity to oxytocin administration. 相似文献
358.
Thomas Meyer Erma Salkic Torsten Grehl Ute Weyen Dagmar Kettemann Patrick Weydt René Günther Paul Lingor Jan Christoph Koch Susanne Petri Andreas Hermann Johannes Prudlo Julian Großkreutz Petra Baum Matthias Boentert Moritz Metelmann Jenny Norden Isabell Cordts Jochen H. Weishaupt Johannes Dorst Albert Ludolph Yasemin Koc Bertram Walter Christoph Münch Susanne Spittel Marie Dreger André Maier Péter Körtvélyessy 《European journal of neurology》2023,30(6):1600-1610
Background and purpose
The objective was to assess the performance of serum neurofilament light chain (sNfL) in amyotrophic lateral sclerosis (ALS) in a wide range of disease courses, in terms of progression, duration and tracheostomy invasive ventilation (TIV).Methods
A prospective cross-sectional study at 12 ALS centers in Germany was performed. sNfL concentrations were age adjusted using sNfL Z scores expressing the number of standard deviations from the mean of a control reference database and correlated to ALS duration and ALS progression rate (ALS-PR), defined by the decline of the ALS Functional Rating Scale.Results
In the total ALS cohort (n = 1378) the sNfL Z score was elevated (3.04; 2.46–3.43; 99.88th percentile). There was a strong correlation of sNfL Z score with ALS-PR (p < 0.001). In patients with long (5–10 years, n = 167) or very long ALS duration (>10 years, n = 94) the sNfL Z score was significantly lower compared to the typical ALS duration of <5 years (n = 1059) (p < 0.001). Furthermore, in patients with TIV, decreasing sNfL Z scores were found in correlation with TIV duration and ALS-PR (p = 0.002; p < 0.001).Conclusions
The finding of moderate sNfL elevation in patients with long ALS duration underlined the favorable prognosis of low sNfL. The strong correlation of sNfL Z score with ALS-PR strengthened its value as progression marker in clinical management and research. The lowering of sNfL in correlation with long TIV duration could reflect a reduction either in disease activity or in the neuroaxonal substrate of biomarker formation during the protracted course of ALS. 相似文献359.
Helena Isabell Riedemann Morna F. Schmidt Jens Malte Baron 《Journal der Deutschen Dermatologischen Gesellschaft》2023,21(7):761-776
A scar develops following the appearance of a deep tissue defect as part of the physiological wound healing process. The initial inflammatory response is followed by proliferation of connective tissue cells, which form fibrosis as a final tissue substitute. Disorders can occur at all stages of the process and are most commonly manifested as impaired wound healing or the formation of atrophic and hypertrophic scars or keloids. The focus of this article is on the treatment of pathologic scars, which are an indication for therapy due to functional limitations, complaints, and stigmatization, among other reasons. Conservative medical, physical, surgical and laser therapeutic approaches are pursued. The basis for this is an understanding of the pathophysiological mechanisms and factors influencing the choice of therapy, as well as an interdisciplinary and interprofessional therapeutic approach. 相似文献