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31.
Niemann S Sereda Mw Suter U Griffiths Ir Nave Ka. 《Journal of the peripheral nervous system : JPNS》2000,5(4):245-245
Hyperexcitability of the primary afferent neuron leads to neuropathic pain following injury to peripheral axons. Changes in calcium channel function of sensory neurons following injury have not been directly examined at the channel level, even though calcium is a primary second messenger-regulating neuronal function. We compared calcium currents (I-Ca) in 101 acutely isolated dorsal root ganglion neurons from 31 rats with neuropathic pain following chronic constriction injury (CCI) of the sciatic nerve, to cells from 25 rats with normal sensory function following sham surgery. Cells projecting to the sciatic nerve were identified with a fluorescent label applied at the CCI site. Membrane function was determined using patch-clamp techniques in current clamp mode, and in voltage-clamp mode using solutions and conditions designed to isolate I-Ca. Somata of peripheral sensory neurons from hyperalgesic rats demonstrated decreased I-Ca. Peak calcium channel current density was diminished by injury from 3.06 +/− 0.30 pS/pF to 2.22 +/− 0.26 pS/pF in medium neurons, and from 3.93 +/− 0.38 pS/ pF to 2.99 +/− 0.40 pS/pF in large neurons. Under these voltage and pharmacologic conditions, medium-sized neuropathic cells lacked obvious T-type calcium currents which were present in 25% of medium-sized cells from control animals. Altered Ca2+ signalling in injured sensory neurons may contribute to hyperexcitability leading to neuropathic pain. 相似文献
32.
Lucas Schreiner Thaís Guimarães dos Santos Mara Regina Knorst Irênio Gomes da Silva Filho 《International urogynecology journal》2010,21(9):1065-1070
Introduction
The aim of this study was to examine the efficacy of transcutaneous electrical tibial nerve stimulation (TTNS) to treat urge urinary incontinence (UUI) in older women. 相似文献33.
34.
Bastelica D Mavri A Verdierl M Berthet B Juhan-Vague I Alessi MC 《Thrombosis and haemostasis》2002,88(3):481-487
Plasminogen activator inhibitor type 1 (PAI-1), a risk marker of atherosclerosis, is highly expressed in adipose tissue from obese subjects. PAI-1 is also considered as an acute phase protein. Recently, adipose tissue has been described as a source of inflammatory cytokines. Therefore, our aim was to study the relationships between PAI-1, and IL-6, TNF, TNF receptors (TNFRSF1s) and TGFbeta1, in plasma and adipose tissue from obese (n = 60) and lean (n = 28) subjects. Study has been extended to plasminogen activators (t-PA and u-PA). Compared to lean subjects, obese subjects exhibited higher plasma levels of all the studied parameters (except for TGFbeta1) whereas in adipose tissue only PAI-1, t-PA and TGFbeta antigen levels differed. In the obese population, plasma PAI-1 levels were weakly associated with circulating TNF, and this relationship disappeared after adjustment for plasma t-PA. Adipose tissue PAI-1 levels were positively associated with TNFRSF1s and TGFbeta, the strongest relationship being observed with TNFRSF1A, which explained 82% of PAI-1 variability. TNF and IL-6 were the main contributors to t-PA variability in plasma and in adipose tissue, respectively. Our results argue on the relevance of TNFRSF1s in the regulation of PAI-1 expression by adipose tissue. Association between t-PA, which is mainly produced by endothelial cells, and IL-6 or TNF suggest that inflammation might be involved in angiogenesis in adipose tissue. 相似文献
35.
Grova C Jannin P Buvat I Benali H Bansard JY Biraben A Gibaud B 《Academic radiology》2005,12(5):554-565
RATIONALE AND OBJECTIVES: In the general context of perfusion pattern modeling from single-photon emission computed tomographic (SPECT) data, the purpose of this study is to characterize interindividual functional variability and functional connectivity between anatomic structures in a set of SPECT data acquired from a homogeneous population of subjects. MATERIALS AND METHODS: From volume of interest (VOI)-perfusion measurements performed on anatomically standardized SPECT data, we proposed to use correspondence analysis (CA) and hierarchical clustering (HC) to explore the structure of statistical dependencies among these measurements. The method was applied to study the perfusion pattern in two populations of subjects; namely, SPECT data from 27 healthy subjects and ictal SPECT data from 10 patients with mesio-temporal lobe epilepsy (MTLE). RESULTS: For healthy subjects, anatomic structures showing statistically dependent perfusion patterns were classified into four groups; namely, temporomesial structures, internal structures, posterior structures, and remaining cortex. For patients with MTLE, they were classified as temporomesial structures, surrounding temporal structures, internal structures, and remaining cortex. Anatomic structures of each group showed similar perfusion behavior so that they may be functionally connected and may belong to the same network. Our main result is that the temporal pole and lenticular nucleus seemed to be highly relevant to characterize ictal perfusion in patients with MTLE. This exploratory analysis suggests that a network involving temporal structures, lenticular nucleus, brainstem, and cerebellum seems to be involved during MTLE seizures. CONCLUSION: CA followed by HC is a promising approach to explore brain perfusion patterns from SPECT VOI measurements. 相似文献
36.
Obesity is associated with increased risk of cardiovascular morbidity. Biologically active molecules produced by adipose tissue constitute a critical link between obesity and cardiovascular complications. Adipose tissue has recently been recognized to be an important endocrine organ that controls energy metabolism. It also secretes adipocytokines, which can modify vascular responses, and antifibrinolytics, including plasminogen activator inhibitor 1, which favors fibrin accumulation, and proinflammatory cytokines, which facilitate the inflammatory response. Here we review new advances in our understanding of the mechanisms linking the endocrine activity of adipose tissue to vascular risk. 相似文献
37.
We performed 43 open partial nephrectomies with different indications between 1996 and 2004, most of them (29) for renal cancer. We used different types of biocompatible materials for haemostasis. We describe our own recommendations and what is described in literature. 相似文献
38.
We analyse the improving role of teaching microsurgery, the advantages of the microsurgical models in research and clinical practice. We summarize our experience in teaching basic microsurgery according to Furka's model in the last 15 years. The main characteristics of the principles are: activity, synchronism, video assistance, self-control, individualization, analysis. We show the curriculum of the courses for researchers and participants in graduate and postgraduate education, which consists dry-training on models followed by surgical interventions on rats. Summarizing of our practices: to learn the basic microsurgical techniques the participants need endurance, patience, and have to work hard. Effectiveness of the education is most successful if we organize small groups, if one teacher deals with a maximum of two or three candidates. 相似文献
39.
Svébis M Pap-Szekeres J Venczel L Gera L Rajtár M Sinkó M Furka I Mikó I 《Magyar sebészet》2005,58(2):80-83
We performed splenectomy combined with spleen autotransplantation after blunt abdominal trauma by minimally invasive technique at the County Teaching Hospital in Kecskemét. In case of advanced post traumatic spleen injury, spleen autotransplantation (Furka's spleen chips) is a well-known method to try to avoid postsplenectomy syndrome. During the operation, when in situ preservation of the spleen is not possible, chips of spleen tissue are transplanted into the omentum. Function of the transplanted spleen tissue was monitored by scintigraphy. We describe two different types of spleen scintigraphy to check the viability of spleen chips. 相似文献
40.
Mikó I Serfozo J Kappelmayer J Sipka S Furka A Imre S Galuska L Kovács J Bráth E Peto K Németh N Furka I 《Magyar sebészet》2005,58(2):69-73
Researches of different spleen salvaging techniques have begun in 1986 at our department. The early purpose was to develop new spleen preservation surgical techniques, such as spleen autotransplantation and spleen resection. Besides the morphological and radiological examinations we also performed different investigations including hemorheological, hemostaseological and immunological follow-up of the splenic function. From these parameters changes in red blood cell deformability and peripheral phagocyte activity could indicate the possible complications originated from the reduced splenic function. Recent paper takes a survey of these experiences. 相似文献