全文获取类型
收费全文 | 3144篇 |
免费 | 205篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 93篇 |
妇产科学 | 31篇 |
基础医学 | 536篇 |
口腔科学 | 72篇 |
临床医学 | 291篇 |
内科学 | 615篇 |
皮肤病学 | 141篇 |
神经病学 | 285篇 |
特种医学 | 104篇 |
外科学 | 329篇 |
综合类 | 11篇 |
预防医学 | 268篇 |
眼科学 | 46篇 |
药学 | 251篇 |
中国医学 | 13篇 |
肿瘤学 | 257篇 |
出版年
2024年 | 6篇 |
2023年 | 29篇 |
2022年 | 108篇 |
2021年 | 131篇 |
2020年 | 65篇 |
2019年 | 98篇 |
2018年 | 101篇 |
2017年 | 72篇 |
2016年 | 85篇 |
2015年 | 114篇 |
2014年 | 129篇 |
2013年 | 171篇 |
2012年 | 239篇 |
2011年 | 283篇 |
2010年 | 168篇 |
2009年 | 127篇 |
2008年 | 204篇 |
2007年 | 213篇 |
2006年 | 183篇 |
2005年 | 147篇 |
2004年 | 128篇 |
2003年 | 113篇 |
2002年 | 120篇 |
2001年 | 39篇 |
2000年 | 26篇 |
1999年 | 27篇 |
1998年 | 37篇 |
1997年 | 16篇 |
1996年 | 14篇 |
1995年 | 22篇 |
1994年 | 11篇 |
1993年 | 8篇 |
1992年 | 15篇 |
1991年 | 23篇 |
1990年 | 10篇 |
1989年 | 12篇 |
1988年 | 8篇 |
1987年 | 8篇 |
1986年 | 4篇 |
1985年 | 7篇 |
1984年 | 5篇 |
1982年 | 3篇 |
1981年 | 6篇 |
1978年 | 5篇 |
1977年 | 3篇 |
1976年 | 4篇 |
1975年 | 4篇 |
1974年 | 6篇 |
1965年 | 2篇 |
1959年 | 2篇 |
排序方式: 共有3374条查询结果,搜索用时 15 毫秒
11.
Ines Lessa Maria Jenny Araújo Lucélia Magalh?es Naomar de Almeida Filho Estela Aquino Maria Cecília R Costa 《Pan American journal of public health》2004,16(2):131-137
OBJECTIVE: To estimate the frequency of modifiable cardiovascular risk factors, with and without inclusion of arterial hypertension, occurring simultaneously in a racially-mixed population. METHOD: A cross-sectional study was carried out with 1,298 adults aged > or = 20 years in the city of Salvador, Brazil, in 2000. Eight modifiable cardiovascular risk factors were assessed, in any combination: total cholesterol > or = 240 mg/dL; high density-lipoprotein cholesterol (HDL-c) < 40 mg/dL; triglycerides > or = 200 mg/dL; glycemia > or = 126 mg/dL + well-controlled diabetes; body mass index > or = 25 kg/m2, waist > or = 102 cm for males and > or = 88 cm for females, smoking and alcoholism. The results were stratified according to the number of simultaneous risk factors (zero to five or more and two or more risk factors). The data were analyzed in terms of estimated proportions and 95% confidence intervals (95%CI), with and without the inclusion of arterial hypertension (VI Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure [JNC-VI], United States of America), ratio of proportions and chi-square for proportions as a measure of association. RESULTS: Among men (41.4% of participants), 7.5% (95%CI: 2.5 to 9.7) did not present risk factors; 68.8% (95%CI: 65.0 to 72.8) presented two or more risk factors, not including hypertension. After inclusion of hypertension, 73.4% (95%CI: 69.7 to 77.1) presented two or more risk factors. Among women, 11.6% did not present risk factors. The presence of two or more risk factors, not including hypertension, was observed in 67.7% (95%CI: 64.8 to 71.4). After inclusion of hypertension, 71.7% (95%CI: 68.5 to 74.9) of the women presented two or more risk factors. Significant differences were observed for the presence of two or more risk factors in men with not more than 4 years of schooling vs. 5 to less than 11 years of schooling (P < 0.05); in women with not more than 4 years of schooling vs. 5 to less than 11 years of schooling; in women with not more than 4 years of schooling vs. 11 or more years of schooling (P < 0.01); and in black vs. white women (P < 0.01). CONCLUSIONS: The high proportion of clustering cardiovascular risk factors in Salvador, with or without hypertension, especially in the population with little schooling and in black individuals, suggests the need for broad social strategies to reduce social inequality, promote health, and facilitate the treatment of cardiovascular risk factors. 相似文献
12.
Yassine Chtourou Maram Morjen Rahma Ammar Rania Mhiri Mohamed Jema Ines ELBini-Dhouib Hamadi Fetoui Najet Srairi-Abid Naziha Marrakchi Jed Jebali 《Nutrients》2022,14(14)
Natural polyphenols are widely reported to have a large range of pharmacological properties, especially antioxidant activities and free radical scavenging capacities. In this study, we investigate the effects of naringin, chlorogenic acid, and quercetin mixtures (NCQ) on renal fibrosis in streptozotocin (STZ)-induced diabetic aged rats and its underlying mechanisms for ten consecutive weeks. The oxidative defense system in the kidneys of treated rats was found to be improved. Several biomarkers were investigated including the blood urea nitrogen, creatinine, and uric acid. Moreover, antioxidant parameters were evaluated and we found that superoxide dismutase, catalase, glutathione peroxidase, Na+-K+-ATPase activities, the nitric oxide production, the protein carbonyl, the advanced oxidation protein products, lipid peroxidation, and reduced glutathione levels were all significantly balanced and close to control values. In addition, NCQ restored renal injuries and fibrosis as assessed by histological method and molecular biology investigation of the matrix metalloproteinase, the transforming growth factor-beta TGF-β, the tumor necrosis factor TNFα, and p53 expression. Our study proposes the NCQ combination as potential plant-derived bioactive compounds to prevent diabetic nephropathy. 相似文献
13.
14.
15.
16.
17.
18.
19.
O Pullig B Kladny G Weseloh B Swoboda 《Zeitschrift für Orthop?die und ihre Grenzgebiete》1999,137(1):67-75
OBJECTIVE/METHODS: Type II collagen is the dominating collagen in articular cartilage. It is essential for the structural integrity and the biomechanical properties of cartilage. Using immunohistology and in situ hybridization we systematically analyzed the protein and mRNA-expression of type II collagen in cartilage/bone sections without any signs of osteoarthritis and osteoarthritic samples with various degrees of osteoarthritis. RESULTS: In normal articular cartilage without any histologic signs of osteoarthritis type II collagen was distributed homogeneously. An expression of the type II collagen-mRNA was not detectable in any of these samples. In cartilage sections with a roughening of the cartilage surface and a superficial loss of the safranin O staining as early histologic signs of osteoarthritis the immunohistologic staining for type II collagen was reduced in the deep cartilage zone. An expression of the type II collagen-mRNA was found in 19 of 35 preparations. This expression, however, was restricted to the middle and deep zone of cartilage. A good and reproducible correlation of the specific gene and protein expression was found in samples with more severe osteoarthritic lesions. CONCLUSIONS: Detailed information on metabolic changes and the activation of chondrocytes in osteoarthritic cartilage are important to characterize certain stages of osteoarthritis and thus identify new prognostic factors. Increasing knowledge of the factors regulating the matrix synthesis and degradation in cartilage will provide the basis for new disease modifying therapies in osteoarthritis. 相似文献
20.
Ines Testoni Michael Wieser Alessandra Armenti Lucia Ronconi Maria Silvia Guglielmin Paolo Cottone Adriano Zamperini 《Zeitschrift für Psychodrama und Soziometrie》2016,15(1):11-23
The study discusses the construct of spontaneity and its causal relationship with psychological well-being. It develops a preview phase of validation of the SAI-R and its correlation with the Clinical Outcomes for Routine Evaluation-Outcome Measure (CORE-OM) and the Beck Depression Inventory (BDI-II) and assumes the hypothesis that a high level of spontaneity is correlated negatively with low level of well-being and positively with depression. The research involved Italian and Austrian participants, consisting of 166 Italian and 146 Austrian university students. The findings suggested a causal relationship between low spontaneity and psychological suffering. The results obtained confirm the hypothesized model, showing significant negative causal relationship. The verification of this theoretical model on non-clinical samples allows us to set the ground for future use in clinical samples. Furthermore, this result encourages the development of further research into the use of SAI-R. 相似文献