全文获取类型
收费全文 | 2433篇 |
免费 | 149篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 51篇 |
儿科学 | 69篇 |
妇产科学 | 62篇 |
基础医学 | 299篇 |
口腔科学 | 58篇 |
临床医学 | 189篇 |
内科学 | 669篇 |
皮肤病学 | 78篇 |
神经病学 | 154篇 |
特种医学 | 89篇 |
外科学 | 280篇 |
综合类 | 25篇 |
预防医学 | 237篇 |
眼科学 | 66篇 |
药学 | 117篇 |
中国医学 | 12篇 |
肿瘤学 | 132篇 |
出版年
2023年 | 18篇 |
2022年 | 33篇 |
2021年 | 93篇 |
2020年 | 37篇 |
2019年 | 75篇 |
2018年 | 88篇 |
2017年 | 51篇 |
2016年 | 49篇 |
2015年 | 78篇 |
2014年 | 86篇 |
2013年 | 92篇 |
2012年 | 124篇 |
2011年 | 144篇 |
2010年 | 73篇 |
2009年 | 78篇 |
2008年 | 128篇 |
2007年 | 142篇 |
2006年 | 120篇 |
2005年 | 100篇 |
2004年 | 116篇 |
2003年 | 110篇 |
2002年 | 92篇 |
2001年 | 68篇 |
2000年 | 76篇 |
1999年 | 73篇 |
1998年 | 16篇 |
1997年 | 19篇 |
1996年 | 6篇 |
1995年 | 15篇 |
1994年 | 8篇 |
1992年 | 30篇 |
1991年 | 30篇 |
1990年 | 33篇 |
1989年 | 41篇 |
1988年 | 24篇 |
1987年 | 21篇 |
1986年 | 21篇 |
1985年 | 21篇 |
1984年 | 21篇 |
1983年 | 15篇 |
1982年 | 7篇 |
1981年 | 8篇 |
1979年 | 8篇 |
1978年 | 10篇 |
1976年 | 13篇 |
1975年 | 8篇 |
1974年 | 7篇 |
1973年 | 8篇 |
1970年 | 5篇 |
1969年 | 5篇 |
排序方式: 共有2587条查询结果,搜索用时 15 毫秒
31.
In this paper, the approach to the genesis of the acute hypertension of pregnancy, uses a conceptual and methodological perspective adjusted to its multifactorial nature; a set of questions with epidemiologic focus is proposed, in order to vinculate psychosocial factors with the biologic processes characteristic of this health problem. 相似文献
32.
G M Dosik M Luna M Valdivieso K B McCredie E A Gehan B Gil-Extremera T L Smith G P Bodey 《The American journal of medicine》1979,67(4):646-656
Necrotizing lesions of the colon occur in patients with malignancy. We identified 26 patients with cancer (23 with acute leukemia and three with solid tumors) who died from necrotizing colitis. Autopsies revealed three pathologic categories: pseudomembranous colitis in 69 per cent, agranulocytic colitis in 19 per cent and ischemic colitis in 12 per cent. Most died from sepsis. A comparison of characteristics was made with a control population matched for diagnosis, age, cause of death and duration of neoplasia. Nearly all patients in both groups had fever and were granulocytopenic secondary to chemotherapy. Most received antineoplastic and antimicrobial regimens during the month prior to their terminal illness. Abdominal pain and distention, stomatitis and necrotizing pharyngitis were frequently associated with colitis. Hyperbilirubinemia was a frequent late complication in those with colitis and the control group. Single and multiorganism septicemia were found more frequently in patients with colitis. As antemortem diagnosis was unusual, aggressive attempts at diagnosis are necessary to assess the true incidence of this disorder and the best therapy. 相似文献
33.
Factors associated with microalbuminuria in type 1 diabetes mellitus: a cross-sectional study 总被引:1,自引:0,他引:1
Campos-Pastor MM Escobar-Jiménez F Mezquita P Herrera-Pombo JL Hawkins-Carranza F Luna JD Azriel S Serraclara A Rigopoulos M 《Diabetes research and clinical practice》2000,48(1):43-49
In order to determine the prevalence of microalbuminuria in people with Type 1 diabetes mellitus (Type 1 DM) and identify factors associated with microalbuminuria, we studied 312 Type 1 DM patients attending in three hospitals in two Spanish regions over 6 months. Clinical characteristics, micro- and macro-vascular complications, blood pressure, 24-h urine albumin excretion, lipid profile, HbA1(c) levels, smoking habits, and family history of hypertension and diabetic nephropathy were recorded. Univariate analysis and multiple logistic regression were used to examine associations between these variables and the prevalence of microalbuminuria. We detected microalbuminuria in 29% of the patients. The prevalence of microalbuminuria was high during the second decade of diabetes and declined thereafter. Univariate analysis showed dyslipidaemia (P<0. 002), previously diagnosed hypertension (P<0.001), family history of hypertension (sibling alone P<0.006; mother alone P<0.05), family history of diabetic nephropathy (P<0.001), and laser-treated retinopathy (P<0.03) to be factors associated with the presence of microalbuminuria. Multiple logistic regression revealed an association between microalbuminuria and family history of nephropathy (OR 7.6, 3.6-16). In conclusion, in our sample the frequency of microalbuminuria seems to be related to the presence of dyslipidaemia, hypertension, and to a family history of hypertension or nephropathy. 相似文献
34.
Carmen Vidal Liliana Porras-Hurtado Raquel Cruz Joaquín Quiralte Victoria Cardona Carlos Colás Luisa F. Castillo Carmen Marcos Teresa Soto Raquel Lopez-Abad Dolores Hernández Maria Teresa Audicana Margarita Armisén Virginia Rodríguez Celsa Perez-Carral Esther Moreno Rosario Cabañes Mercè Corominas Antonio Parra Teófilo Lobera Dolores Quiñones Pedro Ojeda Ildefonso Luna María Torres Angel Carracedo 《The Journal of allergy and clinical immunology》2013
35.
Ana Marcos-Jiménez Santiago Sánchez-Alonso Ana Alcaraz-Serna Laura Esparcia Celia López-Sanz Miguel Sampedro-Núñez Tamara Mateu-Albero Ildefonso Sánchez-Cerrillo Pedro Martínez-Fleta Ligia Gabrie Luciana del Campo Guerola José Miguel Rodríguez-Frade José M. Casasnovas Hugh T. Reyburn Mar Valés-Gómez Margarita López-Trascasa Enrique Martín-Gayo María José Calzada Santos Castañeda Hortensia de la Fuente Isidoro González-Álvaro Francisco Sánchez-Madrid Cecilia Muñoz-Calleja Arantzazu Alfranca 《European journal of immunology》2021,51(3):634-647
SARS-CoV-2 infection causes an abrupt response by the host immune system, which is largely responsible for the outcome of COVID-19. We investigated whether the specific immune responses in the peripheral blood of 276 patients were associated with the severity and progression of COVID-19. At admission, dramatic lymphopenia of T, B, and NK cells is associated with severity. Conversely, the proportion of B cells, plasmablasts, circulating follicular helper T cells (cTfh) and CD56–CD16+ NK-cells increased. Regarding humoral immunity, levels of IgM, IgA, and IgG were unaffected, but when degrees of severity were considered, IgG was lower in severe patients. Compared to healthy donors, complement C3 and C4 protein levels were higher in mild and moderate, but not in severe patients, while the activation peptide of C5 (C5a) increased from the admission in every patient, regardless of their severity. Moreover, total IgG, the IgG1 and IgG3 isotypes, and C4 decreased from day 0 to day 10 in patients who were hospitalized for more than two weeks, but not in patients who were discharged earlier. Our study provides important clues to understand the immune response observed in COVID-19 patients, associating severity with an imbalanced humoral response, and identifying new targets for therapeutic intervention. 相似文献
36.
Asal Milhem Hanifa J. Abu ToamihAtamni Luna Karkar Yael HouriHaddad Fuad A. Iraqi 《动物模型与实验医学(英文)》2021,4(1):27
BackgroundMultimorbidity of intestinal cancer (IC), type 2 diabetes (T2D) and obesity is a complex set of diseases, affected by environmental and genetic risk factors. High‐fat diet (HFD) and oral bacterial infection play important roles in the etiology of these diseases through inflammation and various biological mechanisms.MethodsTo study the complexity of this multimorbidity, we used the collaborative cross (CC) mouse genetics reference population. We aimed to study the multimorbidity of IC, T2D, and obesity using CC lines, measuring their responses to HFD and oral bacterial infection. The study used 63 mice of both sexes generated from two CC lines (IL557 and IL711). For 12 weeks, experimental mice were maintained on specific dietary regimes combined with co‐infection with oral bacteria Porphyromonas gingivalis and Fusobacterium nucleatum, while control groups were not infected. Body weight (BW) and results of a intraperitoneal glucose tolerance test (IPGTT) were recorded at the end of 12 weeks, after which length and size of the intestines were assessed for polyp counts.ResultsPolyp counts ranged between 2 and 10 per CC line. The combination of HFD and infection significantly reduced (P < .01) the colon polyp size of IL557 females to 2.5 cm2, compared to the other groups. Comparing BW gain, IL557 males on HFD gained 18 g, while the females gained 10 g under the same conditions and showed the highest area under curve (AUC) values of 40 000‐45 000 (min mg/dL) in the IPGTT.ConclusionThe results show that mice from different genetic backgrounds respond differently to a high fat diet and oral infection in terms of polyp development and glucose tolerance, and this effect is gender related. 相似文献
37.
Luna Leandro H. Aranda Claudia M. Monge Calleja Álvaro M. Santos Ana Luísa 《International journal of legal medicine》2021,135(3):993-1003
International Journal of Legal Medicine - Non-adult sex estimation is an active field of forensic inquiry as morphological variations between males and females are subtle, but observable, even from... 相似文献
38.
Cytomegalovirus prevention strategies in seropositive kidney transplant recipients: an insight into current clinical practice 下载免费PDF全文
Mario Fernández‐Ruiz Manuel Arias Josep M. Campistol David Navarro Ernesto Gómez‐Huertas Gonzalo Gómez‐Márquez Juan Manuel Díaz Domingo Hernández Gabriel Bernal‐Blanco Frederic Cofan Luisa Jimeno Antonio Franco‐Esteve Esther González Francesc J. Moreso Carlos Gómez‐Alamillo Alicia Mendiluce Enrique Luna‐Huerta José María Aguado the OPERA Study Group 《Transplant international》2015,28(9):1042-1054
There is notable heterogeneity in the implementation of cytomegalovirus (CMV) prevention practices among CMV‐seropositive (R+) kidney transplant (KT) recipients. In this prospective observational study, we included 387 CMV R+ KT recipients from 25 Spanish centers. Prevention strategies (antiviral prophylaxis or preemptive therapy) were applied according to institutional protocols at each site. The impact on the 12‐month incidence of CMV disease was assessed by Cox regression. Asymptomatic CMV infection, acute rejection, graft function, non‐CMV infection, graft loss, and all‐cause mortality were also analyzed (secondary outcomes). Models were adjusted for a propensity score (PS) analysis for receiving antiviral prophylaxis. Overall, 190 patients (49.1%) received preemptive therapy, 185 (47.8%) antiviral prophylaxis, and 12 (3.1%) no specific intervention. Twelve‐month cumulative incidences of CMV disease and asymptomatic infection were 3.6% and 39.3%, respectively. Patients on prophylaxis had lower incidence of CMV disease [PS‐adjusted HR (aHR): 0.10; 95% confidence interval (CI): 0.01–0.79] and asymptomatic infection (aHR: 0.46; 95% CI: 0.29–0.72) than those managed preemptively, with no significant differences according to the duration of prophylaxis. All cases of CMV disease in the prophylaxis group occurred after prophylaxis discontinuation. There were no differences in any of the secondary outcomes. In conclusion, antiviral prophylaxis was associated with a lower occurrence of CMV disease in CMV R+ KT recipients, although such benefit should be balanced with the risk of late‐onset disease. 相似文献
39.
In this paper we studied the role of thyroid gland function in two experimental hypertension models with different pathophysiological mechanisms: deoxycorticosterone-salt (DOCA-salt, volume dependent) and Goldblatt 2-kidney, 1-clip (2K1C, renin dependent). DOCA-salt hypertensive rats showed lower T3 and T4 serum levels by the third week of induced hypertension. Goldblatt 2K1C hypertensive rats, however, exhibited normal values for both hormones. Treatment with thyroxine accelerated the evolution of hypertension and did not affect the PRA of DOCA-salt rats. Radiothyroidectomy inhibited DOCA-salt and Goldblatt 2K1C hypertension, and prevented the suppression of PRA in DOCA-salt rats, without altering PRA or serum aldosterone in Goldblatt 2K1C rats. These results suggest that: a) a thyroid depressing factor is not activated in Goldblatt 2K1C rats; b) thyroidectomy interferes with the suppressor effect of mineralocorticoid on renin secretion; and c) normal thyroid activity is required for the hypertensive effect of the renin-angiotensin-aldosterone system in Goldblatt 2K1C rats. 相似文献
40.
Yochai Birnbaum Miguel Fiol Kjell Nikus Javier Garcia Niebla Ljuba Bacharova Sergio Dubner Wojciech Zareba Peter W. Macfarlane Antonio Luiz Ribeiro Iwona Cygankiewicz Antoni Bayes de Luna 《Annals of noninvasive electrocardiology》2020,25(5)
The Fourth Universal Definition of Myocardial Infarction (FUDMI) focuses on the distinction between nonischemic myocardial injury and myocardial infarction (MI), along with the role of cardiovascular magnetic resonance, in order to define the etiology of myocardial injury. As a consequence, there is less emphasis on updating the parts of the definition concerning the electrocardiographic (ECG) changes related to MI. Evidence of myocardial ischemia is a prerequisite for the diagnosis of MI, and the ECG is the main available tool for (a) detecting acute ischemia, (b) triage, and (c) risk stratification upon presentation. This review focuses on multiple aspects of ECG interpretation that we firmly believe should be considered for incorporation in any future update to the Universal Definition of MI. 相似文献