全文获取类型
收费全文 | 3252篇 |
免费 | 200篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 98篇 |
妇产科学 | 71篇 |
基础医学 | 458篇 |
口腔科学 | 33篇 |
临床医学 | 288篇 |
内科学 | 947篇 |
皮肤病学 | 63篇 |
神经病学 | 420篇 |
特种医学 | 64篇 |
外科学 | 255篇 |
综合类 | 6篇 |
预防医学 | 151篇 |
眼科学 | 60篇 |
药学 | 221篇 |
中国医学 | 4篇 |
肿瘤学 | 342篇 |
出版年
2024年 | 10篇 |
2023年 | 55篇 |
2022年 | 121篇 |
2021年 | 185篇 |
2020年 | 119篇 |
2019年 | 134篇 |
2018年 | 141篇 |
2017年 | 85篇 |
2016年 | 115篇 |
2015年 | 150篇 |
2014年 | 153篇 |
2013年 | 183篇 |
2012年 | 298篇 |
2011年 | 312篇 |
2010年 | 168篇 |
2009年 | 154篇 |
2008年 | 217篇 |
2007年 | 170篇 |
2006年 | 172篇 |
2005年 | 128篇 |
2004年 | 120篇 |
2003年 | 116篇 |
2002年 | 92篇 |
2001年 | 22篇 |
2000年 | 8篇 |
1999年 | 9篇 |
1998年 | 14篇 |
1997年 | 4篇 |
1996年 | 7篇 |
1995年 | 5篇 |
1994年 | 2篇 |
1993年 | 6篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 4篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1978年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有3492条查询结果,搜索用时 15 毫秒
101.
Aurélie Mbeutcha Ilaria Lucca Vitaly Margulis Jose A. Karam Christopher G. Wood Michela de Martino Romain Mathieu Andrea Haitel Evanguelos Xylinas Luis Kluth Morgan Rouprêt Pierre I. Karakiewicz Alberto Briganti Michael Rink Malte Rieken Alon Z. Weizer Jay D. Raman Nathalie Rioux-Leclecq Christian Bolenz Karim Bensalah Yair Lotan Christian Seitz Mesut Remzi Shahrokh F. Shariat Tobias Klatte 《World journal of urology》2016,34(8):1155-1161
Background
Excision repair cross-complementing 1 (ERCC1) has been associated with outcomes of urothelial carcinoma of the bladder, but was not yet studied in upper tract urothelial carcinoma (UTUC). The aim of this study was to assess the prognostic role of ERCC1 expression in a large international cohort of UTUC patients.Methods
Immunohistochemical ERCC1 expression was evaluated in 716 UTUC patients who underwent radical nephroureterectomy with curative intent. ERCC1 was considered positive when the H-score was >1.0. Associations with overall survival and cancer-specific survival were assessed using univariable and multivariable Cox models.Results
ERCC1 was expressed in 303 tumors (42.3 %) and linked with the presence of tumor necrosis (16.2 vs. 10.4 %, p = 0.023), but not with any other clinical or pathological variable. ERCC1 status did not predict cancer-specific survival and overall survival on both univariable (p = 0.70 and 0.32, respectively) and multivariable analyses (p = 0.48 and 0.33, respectively).Conclusions
ERCC1 is expressed in a significant proportion of UTUC and is linked with tumor necrosis, but its expression appears not to be associated with prognosis following radical nephroureterectomy.102.
Ferdinando Antonio Gulino Emanuela Leonardi Ilaria Marilli Giulia Musmeci Salvatore Giovanni Vitale Vito Leanza 《Gynecological endocrinology》2016,32(1):65-68
Introduction: Myo-inositol (MI) is a precursor for the synthesis of phosphatidylinositol polyphosphates (PIPs). The aim of the study is to evaluate the effect of its administration on semen parameters of male patients undergoing an in vitro fertilization cycles.Methods: In vivo study. Samples were semen of 62 patients divided into three different groups: healthy fertile patients (Group A); patients with oligoasthenospermia (OA) (Group B); control group (CTR). The collected samples were analyzed by optic microscopy in order to evaluate semen’s volume, spermatozoa’s number and motility before and after density-gradient separation method. These parameters were evaluated before and after administration of 4000?mg/die of MI and 400?µg of folic acid for 2 months. The results were analyzed statistically with Student's t-test.Results: After treatment there was a significant increase of basal and after density-gradient separation method spermatozoa concentration in Group B, and a significant increase of spermatozoa count after density-gradient separation method in Group A. The motility values were higher in healthy men than patients with OA before treatment, but there was no improvement in both groups after treatment.Conclusions: Exogenous administration of MI significantly improves semen’s parameters both in patients with OA and in normal fertile men. 相似文献
103.
104.
Teresa Calabró Rupert Van Rooyen Ilaria Piraino Elisa Pala Giulia Trovarelli Georgios N. Panagopoulos Panayiotis D. Megaloikonomos Andrea Angelini Andreas F. Mavrogenis Pietro Ruggieri 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2016,26(4):415-421
Background
Various megaprostheses are currently available for reconstruction of the proximal femur after tumor resection. This study evaluates the survival and complications of a modular megaprosthesis for reconstruction of the proximal femur.Materials and methods
We studied the medical files of 109 tumor patients (age range 16–86 years) who underwent proximal femoral reconstruction with the MRP® megaprosthesis from 2002 to 2011. There were 70 patients with metastases, 34 patients with bone sarcomas, and five patients with hematological malignancies; 82 were primary and 27 were revision reconstructions. Mean follow-up was 2.5 years; 31 patients had a minimum five-year follow-up. We evaluated the survival and function of the patients, and the survival and complications of the megaprostheses.Results
Survival was significantly higher for the patients with bone sarcomas compared to those with metastases and hematological malignancies. Mean MSTS functional score was similar between patients with bone sarcomas and those with hematological malignancies and metastases, and between patients with primary and those with revision reconstructions. Overall survival of the MRP® megaprostheses was 74 % at 5 and 9 years. Fourteen (13.6 %) major complications occurred at a mean period of 1.4 years (range 3 months to 4.5 years); these included infection (5.8 %), dislocation (3.9 %), local recurrence (2.9 %), and acetabular fracture (1 %).Conclusion
MRP® megaprostheses are a valuable reconstruction option after tumor resection of the proximal femur.105.
Pneumo- and neurotropism of avian origin Italian highly pathogenic avian influenza H7N1 isolates in experimentally infected mice 总被引:1,自引:0,他引:1
Rigoni M Shinya K Toffan A Milani A Bettini F Kawaoka Y Cattoli G Capua I 《Virology》2007,364(1):28-35
An experimental infection of mice was performed in order to investigate the potential for interspecies transmission in mammals of Italian HPAI viruses of the H7N1 subtype. Three avian origin isolates were selected, two strains obtained from ostrich (one of which contained a PB2-627 Lysine residue) and one from a chicken. Following intranasal infection of mice, clinical signs and mortality were recorded in the experimental groups challenged with the two ostrich isolates, while only weight loss was observed in those receiving the chicken strain. Viruses were recovered to a varying extent from respiratory and nervous tissues of infected animals. These results suggest that HPAI viruses, other than H5N1 and H7N7, may have zoonotic implications, and support the consensus that AI infections in poultry are to be eradicated rather than contained. 相似文献
106.
Manzoni P Stolfi I Pugni L Decembrino L Magnani C Vetrano G Tridapalli E Corona G Giovannozzi C Farina D Arisio R Merletti F Maule M Mosca F Pedicino R Stronati M Mostert M Gomirato G;Italian Task Force for the Study Prevention of Neonatal Fungal Infections;Italian Society of Neonatology 《The New England journal of medicine》2007,356(24):2483-2495
107.
Ciocca L Gallina I Navacchia E Baldissara P Scotti R 《Computers in biology and medicine》2007,37(3):277-286
Conventional methods to estimate the number of dentinal tubules cannot be considered reliable and repeatable, because results depends on the operator outlining of the tubules contours. In this study, we propose a totally automated computerized analysis technique to evaluate dentinal tubules and their surface area. The comparison test of these conventional with a semi-automatic methods shows that the automated analysis allowed a reliable identification and numbering of dentinal tubules, by means of high-quality images. No statistically significant difference exists in the number of tubules and the total tubule surface area between the control and test groups. 相似文献
108.
Sara?GandiniEmail author Giovanna?Masala Domenico?Palli Benedetta?Cavicchi Calogero?Saieva Ilaria?Ermini Federica?Baldini Patrizia?Gnagnarella Saverio?CainiView authors OrcID profile 《European journal of nutrition》2018,57(7):2323-2332
Purpose
Several studies in recent years have investigated the relationship between alcohol intake and melanoma risk, with conflicting results. To help clarify this issue, we conducted a literature review and dose–response meta-analysis of studies published until June 30th, 2017, that examined the association between alcohol intake (overall and by beverage type) and melanoma risk.Methods
We used random effect models with maximum likelihood estimation to calculate summary relative risk (SRR) and 95% confidence intervals (95%CI).Results
We included 20 independent studies (encompassing 10,555 melanoma cases and over 1.6 million non-cases/controls) published during 1986–2016, of which six had a prospective cohort study design. Adjustment for phenotypic characteristics and sunlight exposure was performed in 11 and nine studies, respectively. Alcohol intake was moderately associated with melanoma risk: the SRR were 1.29 (95% CI 1.14–1.45) for those in the highest vs. lowest category of current alcohol intake, and 1.96 (95% CI 1.02–3.76, I2?=?0%) for cumulative intake. In the dose–response analysis, the increase in risk associated with a 10 g increment in daily alcohol intake was 1.07 (95% CI 1.03–1.11). Risk estimates did not differ by gender, study design and adjustment for confounders; between-studies heterogeneity was acceptable, and there was no evidence of publication bias.Conclusions
Our findings suggest that alcohol drinking may be moderately associated with increased melanoma risk, although residual confounding and bias cannot be ruled out. Further research is needed to confirm these findings, clarify the role of the different alcohol sources, and investigate the interaction with known melanoma risk factors.109.
Aloisi AM Bachiocco V Costantino A Stefani R Ceccarelli I Bertaccini A Meriggiola MC 《Pain》2007,132(Z1):S60-S67
Chronic pain is gender-related, since there is a clear predominance of one sex with respect to the other in most pain syndromes. Gonadal hormones are known to affect the occurrence and incidence of pain. Transsexuals receive cross-sex hormones to develop and maintain somatic characteristics of the opposite sex: male to female transsexuals (MtF) are administered estrogens and anti-androgens, while female to male transsexuals (FtM) are administered androgens. Hence, these subjects represent a model to study the relationship between sex hormones and pain. Questionnaires dealing with sociodemographic data and pain (occurrence, frequency, duration, intensity, location and associated symptoms) were administered to both MtF and FtM transsexuals under hormone treatment for sex reassignment for at least 1 year. Forty-seven MtF and 26 FtM completed the questionnaires. Fourteen of the 47 MtF (29.8%) reported painful conditions, which in 11 subjects were not present before the beginning of hormone treatment. Pain consisted mainly of headaches and breast and musculoskeletal pain. Five subjects suffered from more than one pain condition. Sixteen of the 26 FtM (61.5%) reported pain. In 11 subjects, the pain was present before the beginning of hormone intake, and in 6 of them it improved after testosterone administration. These data suggest that marked changes in sex hormones affect the occurrence of pain in a high percentage of humans but not in all of them. Whether these effects are due to peripheral or central actions of sex steroids is unknown. 相似文献
110.
Morselli P Masciotra L Pinto V Zollino I Brunelli G Carinci F 《The Journal of craniofacial surgery》2007,18(6):1353-1358
This retrospective study was carried out to assess the prognostic value of three classification systems used for staging cutaneous head and neck malignant melanoma (CHNME). Fifty-three patients with histologically proven CHNME were analyzed. Thirty patients were never treated before admission, whereas 23 (43.4%) had a second radical resection of the primary tumor location, 9 (17%) had neck nodes, none had distant metastasis, and all had a minimum of 5 years of follow-up. Results show that T-stage is the most important clinical prognostic parameter, whereas Clark's and Breslow's classifications have lower impact in defining prognosis. Sites of primary tumor determines different clinical outcomes, but this does not reach statistically significant values. A second surgery on the primary tumor location is possible and is effective toward survival. No statistical differences were noted between the previously untreated and treated groups. Neck nodes have to be removed with neck dissection, and this regimen can improve the clinical outcome; however, only 40% of neck positive patients survive more than 5 years. 相似文献