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排序方式: 共有10000条查询结果,搜索用时 31 毫秒
961.
Sarah Al-Beltagi Cristian Alexandru Preda Leah V. Goulding Joe James Juan Pu Paul Skinner Zhimin Jiang Belinda Lei Wang Jiayun Yang Ashley C. Banyard Kenneth H. Mellits Pavel Gershkovich Christopher J. Hayes Jonathan Nguyen-Van-Tam Ian H. Brown Jinhua Liu Kin-Chow Chang 《Viruses》2021,13(2)
The long-term control strategy of SARS-CoV-2 and other major respiratory viruses needs to include antivirals to treat acute infections, in addition to the judicious use of effective vaccines. Whilst COVID-19 vaccines are being rolled out for mass vaccination, the modest number of antivirals in use or development for any disease bears testament to the challenges of antiviral development. We recently showed that non-cytotoxic levels of thapsigargin (TG), an inhibitor of the sarcoplasmic/endoplasmic reticulum (ER) Ca2+ ATPase pump, induces a potent host innate immune antiviral response that blocks influenza A virus replication. Here we show that TG is also highly effective in blocking the replication of respiratory syncytial virus (RSV), common cold coronavirus OC43, SARS-CoV-2 and influenza A virus in immortalized or primary human cells. TG’s antiviral performance was significantly better than remdesivir and ribavirin in their respective inhibition of OC43 and RSV. Notably, TG was just as inhibitory to coronaviruses (OC43 and SARS-CoV-2) and influenza viruses (USSR H1N1 and pdm 2009 H1N1) in separate infections as in co-infections. Post-infection oral gavage of acid-stable TG protected mice against a lethal influenza virus challenge. Together with its ability to inhibit the different viruses before or during active infection, and with an antiviral duration of at least 48 h post-TG exposure, we propose that TG (or its derivatives) is a promising broad-spectrum inhibitor against SARS-CoV-2, OC43, RSV and influenza virus. 相似文献
962.
Human metapneumovirus (HMPV) is an important cause of upper and lower respiratory tract disease in individuals of all ages. It is estimated that most individuals will be infected by HMPV by the age of five years old. Despite this burden of disease, there remain caveats in our knowledge of global genetic diversity due to a lack of HMPV sequencing, particularly at the whole-genome scale. The purpose of this study was to create a simple and robust approach for HMPV whole-genome sequencing to be used for genomic epidemiological studies. To design our assay, all available HMPV full-length genome sequences were downloaded from the National Center for Biotechnology Information (NCBI) GenBank database and used to design four primer sets to amplify long, overlapping amplicons spanning the viral genome and, importantly, specific to all known HMPV subtypes. These amplicons were then pooled and sequenced on an Illumina iSeq 100 (Illumina, San Diego, CA, USA); however, the approach is suitable to other common sequencing platforms. We demonstrate the utility of this method using a representative subset of clinical samples and examine these sequences using a phylogenetic approach. Here we present an amplicon-based method for the whole-genome sequencing of HMPV from clinical extracts that can be used to better inform genomic studies of HMPV epidemiology and evolution. 相似文献
963.
964.
Anne Raben PhD Pia Siig Vestentoft PhD Jennie Brand-Miller PhD Elli Jalo MSc Mathjis Drummen PhD Liz Simpson PhD J. Alfredo Martinez PhD Teodora Handjieva-Darlenska PhD Gareth Stratton PhD Maija Huttunen-Lenz PhD Tony Lam MBA Jouko Sundvall MSc Roslyn Muirhead PhD Sally Poppitt PhD Christian Ritz PhD Kirsi H. Pietiläinen PhD Margriet Westerterp-Plantenga PhD Moira A. Taylor PhD Santiago Navas-Carretero PhD Svetoslav Handjiev PhD Melitta A. McNarry PhD Sylvia Hansen MSc Laura Råman BSc Shannon Brodie MSc Marta P. Silvestre PhD Tanja C. Adam PhD Ian A. Macdonald PhD Rodrigo San-Cristobal PhD Nadka Boyadjieva PhD Kelly A. Mackintosh PhD Wolfgang Schlicht PhD Amy Liu PhD Thomas M. Larsen PhD Mikael Fogelholm DSc 《Diabetes, obesity & metabolism》2021,23(2):324-337
965.
John McCauley Ian G. Barr Terry Nolan Theodore Tsai Steven Rockman Beverly Taylor 《Influenza and other respiratory viruses》2022,16(1):3-6
The COVID-19 pandemic and the measures taken to mitigate its spread have had a dramatic effect on the circulation patterns of other respiratory viruses, most especially influenza viruses. Since April 2020, the global circulation of influenza has been markedly reduced; however, it is still present in a number of different countries and could pose a renewed threat in the upcoming Northern Hemisphere winter. Influenza vaccination remains the most effective preventive measure that we have at our disposal against influenza infections and should not be ignored for the 2021–2022 season. 相似文献
966.
967.
Ramon Z. Shaban Cecilia Li Matthew V. N. O'Sullivan John Gerrard Rhonda L. Stuart Joanne Teh Nicole Gilroy Tania C. Sorrell Elizabeth White Shopna Bag Kate Hackett Sharon C. A. Chen Jen Kok Dominic E. Dwyer Jonathan R. Iredell Susan Maddocks Patricia Ferguson Kavita Varshney Ian Carter Ruth Barratt Mark Robertson Sai R. Baskar Caren Friend Roselle S. Robosa Cristina Sotomayor‐Castillo Shizar Nahidi Deborough A. Macbeth Kylie A. D. Alcorn Andre Wattiaux Frederick Moore Jamie McMahon William Naughton Tony M. Korman Mike Catton Rupa Kanapathipillai Finn Romanes Emily Rowe Jennifer Catford Brendan Kennedy Ming Qiao David Shaw 《Internal medicine journal》2021,51(1):42-51
968.
D. Scott Lim MD Robert L. Smith MD Firas Zahr MD Abhijeet Dhoble MD Roger Laham MD Mohamad Lazkani MD Susheel Kodali MD Chad Kliger MD James Hermiller MD Amit Vora MD Ian J. Sarembock MB ChB MD William Gray MD Samir Kapadia MD Adam Greenbaum MD Andrew Rassi MD David Lee MD Adnan Chhatriwalla MD Pinak Shah MD Josep Rodés-Cabau MD Homam Ibrahim MD Lowell Satler MD Howard C. Herrmann MD Paul Mahoney MD Charles Davidson MD George Petrossian MD Mayra Guerrero MD Konstantinos Koulogiannis MD Leo Marcoff MD Linda Gillam MD The CLASP IID Pivotal Trial Investigators 《Catheterization and cardiovascular interventions》2021,98(4):E637-E646
969.
Aung Myat MD Florence Mouy BMBS Luke Buckner BMBS James Cockburn MD Andreas Baumbach MD Philip MacCarthy PhD Adrian P. Banning MD Nick Curzen PhD Roland Hilling-Smith MD Daniel J. Blackman MD Michael Mullen MD Mark de Belder MD Ian Cox MD Jan Kovac MD Ganesh Manoharan MD Azfar Zaman MD Douglas Muir MBChB David Smith MD Stephen Brecker MD Mark Turner PhD Saib Khogali MD Iqbal S. Malik PhD Osama Alsanjari MRCP Francesca D'Auria PhD Simon Redwood MD Bernard Prendergast DM Uday Trivedi MD Derek Robinson DPhil Peter Ludman MD Adam de Belder MD David Hildick-Smith MD 《Catheterization and cardiovascular interventions》2021,98(3):E444-E452
970.