全文获取类型
收费全文 | 1163篇 |
免费 | 85篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 7篇 |
妇产科学 | 1篇 |
基础医学 | 207篇 |
口腔科学 | 56篇 |
临床医学 | 90篇 |
内科学 | 344篇 |
皮肤病学 | 90篇 |
神经病学 | 116篇 |
特种医学 | 34篇 |
外科学 | 124篇 |
综合类 | 4篇 |
现状与发展 | 1篇 |
预防医学 | 49篇 |
眼科学 | 1篇 |
药学 | 77篇 |
中国医学 | 8篇 |
肿瘤学 | 53篇 |
出版年
2023年 | 7篇 |
2022年 | 11篇 |
2021年 | 31篇 |
2020年 | 30篇 |
2019年 | 19篇 |
2018年 | 44篇 |
2017年 | 20篇 |
2016年 | 47篇 |
2015年 | 60篇 |
2014年 | 67篇 |
2013年 | 93篇 |
2012年 | 113篇 |
2011年 | 112篇 |
2010年 | 77篇 |
2009年 | 54篇 |
2008年 | 77篇 |
2007年 | 65篇 |
2006年 | 66篇 |
2005年 | 67篇 |
2004年 | 41篇 |
2003年 | 28篇 |
2002年 | 29篇 |
2001年 | 24篇 |
2000年 | 24篇 |
1999年 | 16篇 |
1998年 | 10篇 |
1997年 | 10篇 |
1996年 | 3篇 |
1995年 | 5篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1992年 | 6篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 3篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1978年 | 1篇 |
排序方式: 共有1275条查询结果,搜索用时 46 毫秒
41.
42.
Jae Hee Woo Youn Jin Kim Hee Jung Baik Jong In Han Rack Kyung Chung 《Journal of Korean medical science》2014,29(7):1001-1006
Ketamine has anti-inflammatory, analgesic and antihyperalgesic effect and prevents pain associated with wind-up. We investigated whether low doses of ketamine infusion during general anesthesia combined with single-shot interscalene nerve block (SSISB) would potentiate analgesic effect of SSISB. Forty adult patients scheduled for elective arthroscopic shoulder surgery were enrolled and randomized to either the control group or the ketamine group. All patients underwent SSISB and followed by general anesthesia. During an operation, intravenous ketamine was infused to the patients of ketamine group continuously. In control group, patients received normal saline in volumes equivalent to ketamine infusions. Pain score by numeric rating scale was similar between groups at 1, 6, 12, 24, 36, and 48 hr following surgery, which was maintained lower than 3 in both groups. The time to first analgesic request after admission on post-anesthesia care unit was also not significantly different between groups. Intraoperative low dose ketamine did not decrease acute postoperative pain after arthroscopic shoulder surgery with a preincisional ultrasound guided SSISB. The preventive analgesic effect of ketamine could be mitigated by SSISB, which remains one of the most effective methods of pain relief after arthroscopic shoulder surgery.
Graphical Abstract
相似文献43.
Won Young Tak Jin Mo Yang Byung Ik Kim Soon Koo Baik Gab Jin Cheon Kwan Soo Byun Do Young Kim Byung Chul Yoo 《Hepatology International》2014,8(3):375-381
Purpose
Clevudine 30 mg showed potent antiviral activity with a marked post-treatment antiviral effect. However, long-term treatment with clevudine monotherapy induced resistance and myopathy in some cases. The objective of this study is to evaluate the preliminary efficacy and safety of the combination of clevudine 20 mg and adefovir compared to clevudine monotherapy.Methods
Seventy-four patients were randomized to either a combination of clevudine 20 mg and adefovir or clevudine 20 or 30 mg and were treated for 2 years. The viral kinetics for 24 weeks, virological response [VR; hepatitis B virus (HBV) DNA less than 300 copies/ml], and the biochemical response [BR; normal alanine aminotransferase (ALT)] were assessed.Results
There was no difference in baseline characteristics among the three groups. Viral kinetics study showed no statistically significant difference among them during 24 weeks. The combination group showed 95 % virological response with a statistically significant difference compared to the clevudine 30 mg (67 %) and 20 mg (71 %) groups (p = 0.0376). Biochemical response rates were similar in all groups (78–94 %). No resistance was reported in the combination group, while 20 % of patients treated with clevudine 30 mg or 20 mg reported resistance during 2 years. Muscle-related symptoms such as myalgia (1 in clevudine 30 mg, 1 in the combination group) and muscle weakness (1 in clevudine 30 mg, 2 in clevudine 20 mg) were reported in five patients (7 %); of these, three patients discontinued the study.Conclusion
We concluded that the combination of clevudine 20 mg and adefovir produced a potent antiviral response together with a good resistance profile compared to clevudine monotherapy at 96 weeks in this pilot study. 相似文献44.
45.
46.
47.
Kyoung Min Moon Gaeun Kim Soon Koo Baik Eunhee Choi Moon Young Kim Hyoun A Kim Mee Yon Cho Seung Yong Shin Jung Min Kim Hong Jun Park Sang Ok Kwon Young Woo Eom 《Clinical and molecular hepatology》2013,19(4):389-398
Background/Aims
We compared the cirrhosis-prediction accuracy of an ultrasonographic scoring system (USSS) combining six representative sonographic indices with that of liver stiffness measurement (LSM) by transient elastography, and prospectively investigated the correlation between the USSS score and LSM in predicting cirrhosis.Methods
Two hundred and thirty patients with chronic liver diseases (187 men, 43 women; age, 50.4±9.5 y, mean±SD) were enrolled in this prospective study. The USSS produces a combined score for nodularity of the liver surface and edge, parenchyma echogenicity, presence of right-lobe atrophy, spleen size, splenic vein diameter, and abnormality of the hepatic vein waveform. The correlations of the USSS score and LSM with that of a pathological liver biopsy (METAVIR scoring system: F0-F4) were evaluated.Results
The mean USSS score and LSM were 7.2 and 38.0 kPa, respectively, in patients with histologically overt cirrhosis (F4, P=0.017) and 4.3 and 22.1 kPa in patients with fibrotic change without overt cirrhosis (F0-F3) (P=0.025). The areas under the receiver operating characteristic (ROC) curves of the USSS score and LSM for F4 patients were 0.849 and 0.729, respectively. On the basis of ROC curves, criteria of USSS ≥6: LSM ≥17.4 had a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 89.2%:77.6%, 69.4%:61.4%, 86.5%:83.7%, 74.6%:51.9% and 0.83:0.73, respectively, in predicting F4.Conclusions
The results indicate that this USSS has comparable efficacy to LSM in the diagnosis of cirrhosis. 相似文献48.
Jae Hwang Cha Sang Ho Ra Yu Mi Park Yong Kwan Ji Ji Hyun Lee So Yeon Park Soon Koo Baik Sang Ok Kwon Mee Yon Cho Moon Young Kim 《Clinical and molecular hepatology》2013,19(4):421-425
Glycogenic hepatopathy (GH) is an uncommon cause of serum transaminase elevation in type I diabetes mellitus (DM). The clinical signs and symptoms of GH are nonspecific, and include abdominal discomfort, mild hepatomegaly, and transaminase elevation. In this report we describe three cases of patients presenting serum transaminase elevation and hepatomegaly with a history of poorly controlled type I DM. All of the cases showed sudden elevation of transaminase to more than 30 times the upper normal range (like in acute hepatitis) followed by sustained fluctuation (like in relapsing hepatitis). However, the patients did not show any symptom or sign of acute hepatitis. We therefore performed a liver biopsy to confirm the cause of liver enzyme elevation, which revealed GH. Clinicians should be aware of GH so as to prevent diagnostic delay and misdiagnosis, and have sufficient insight into GH; this will be aided by the present report of three cases along with a literature review. 相似文献
49.
Ha M Kim YJ Kwon KA Hahm KB Kim MJ Kim DK Lee YJ Oh SP 《World journal of gastroenterology : WJG》2012,18(15):1840-1844
Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal-dominantly inherited disease that occurs in approximately one in 5000 to 8000 people. Clinical diagnosis of HHT is made when a person presents three of the following four criteria: family history, recurrent nosebleeds, mucocutaneous telangiectasis, and arteriovenous malformations (AVM) in the brain, lung, liver and gastrointestinal (GI) tract. Although epistaxis is the most common presenting symptom, AVMs affecting the lungs, brain and GI tract provoke a more serious outcome. Heterozygous mutations in endoglin, activin receptor-like kinase 1 (ACVRL1; ALK1), and SMAD4, the genes involved in the transforming growth factor-β family signaling cascade, cause HHT. We report here the case of a 63 year-old male patient who presented melena and GI bleeding episodes, proven to be caused by bleeding from multiple gastric angiodysplasia. Esophagogastroduodenoscopy revealed multiple angiodysplasia throughout the stomach. Endoscopic argon plasma coagulation was performed to control bleeding from a gastric angiodysplasia. The patient has been admitted several times with episodes of hemoptysis and hematochezia. One year ago, the patient was hospitalized due to right-sided weakness, which was caused by left basal ganglia hemorrhage as the part of HHT presentation. In family history, the patient's mother and elder sister had died, due to intracranial hemorrhage, and his eldest son has been suffered from recurrent epistaxis for 20 years. A genetic study revealed a mutation in exon 3 of ALK1 (c.199C > T; p.Arg67Trp) in the proband and his eldest son presenting epistaxis. 相似文献
50.