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51.
52.
Nghiem Nguyet Thu Truong Tuyet Mai Tran Th໋ Thu Trang Nguyen Anh Tuan Tran Chau Quyen Nguyen Lien Hanh Nguyen Huu Hoan Bui Thi Huong Lan Phung Thi Hau Ha Huy Tue Truong Viet Dung Ryohei Tsuji Yuta Watanabe Naoki Yamamoto Osamu Kanauchi 《Nutrients》2022,14(3)
Lactococcus lactis strain Plasma (LC-Plasma) is reported to have anti-viral effects via direct activation of plasmacytoid dendritic cells, which upregulate the production of type I and III interferons. A randomized, placebo-controlled, double-blind, parallel group study was designed for elementary schoolchildren, grades 1 to 3, in Vietnam. LC-Plasma or a control were administered to schoolchildren as a beverage (1.0 × 1011 count LC-Plasma/day/person). The primary endpoint was to determine the efficacy of LC-Plasma in reducing the cumulative days absent from school due to upper respiratory disease (URID) and gastrointestinal disease (GID), and the secondary endpoint was to evaluate the potency of LC-Plasma on URID/GID symptoms and general well-being scores. LC-Plasma intake significantly reduced the cumulative days absent from school due to URID/GID (Odds ratio (OR) = 0.57, p = 0.004) and URID alone (OR = 0.56, p = 0.005); LC-Plasma also significantly reduced the number of cumulative fever positive days during the first 4 weeks of intervention (OR = 0.58, p = 0.001) and cumulative days with diarrhea during the last 4 weeks of the intervention period (OR = 0.78, p = 0.01). The number of positive general wellbeing days was significantly improved in the LC-Plasma group compared with the control throughout the intervention period (OR = 0.93, 0.93, p = 0.03, 0.04 in the first and last 4 weeks of the intervention, respectively). These data suggest that LC-Plasma seems to improve the health condition of elementary schoolchildren and reduces school absenteeism due to infectious disease, especially URID. 相似文献
53.
Hussein Abbouchie Michael Chao Mark Tacey Daryl Lim Joon Huong Ho Mario Guerrieri Michael Ng Farshad Foroudi 《Journal of Medical Imaging and Radiation Oncology》2020,64(2):293-302
Stereotactic body radiotherapy has emerged as one of the preferred treatments for patients with spine metastases, with the potential for long‐term control from lesion irradiation. Post‐treatment vertebral compression fractures are a known complication of this therapy, contributing to worsening pain and reduced quality of life, sometimes requiring surgical intervention. This review explores the current knowledge of post‐radiotherapy fractures, in terms of the rates and associated predictive factors. A search of databases including Medline, Embase and the Cochrane Library was conducted using keywords such as ‘vertebral compression fracture’, ‘stereotactic body radiotherapy’ and ‘spine metastases’. The search was limited to published studies up to March 2019, reporting clinical outcomes including both the post‐treatment fracture rate and statistical identification of associated risk factors. Rates of post‐treatment fractures ranged from 4 to 39%. A variety of factors were found to increase the risk, including the appearance of lytic vertebral disease, degree of pre‐existing compression, spinal malalignment, increased dose per fraction and a Spinal Instability Neoplastic Score >6. This knowledge can enable clinicians to counsel patients when considering management options for spine metastases, maintaining the balance between local tumour control and the risk of subsequent fracture. 相似文献
54.
蛋白激酶C在远程预处理诱导脊髓缺血耐受中的作用 总被引:2,自引:0,他引:2
目的:探讨蛋白激酶C在下肢缺血预处理诱导脊髓缺血耐受效应中的作用.方法:实验于2004-07/12在解放军兰州军区乌鲁木齐总医院临床实验室进行.取28只雄性新西兰大白兔,随机分成4组(n=7):①对照组:阻断肾下腹主动脉20min,制作兔脊髓缺血模型.②预处理组:用充气式压力止血带阻断双下肢腘窝上1/3,压力200mmHg(1 mmHg=0.133 kPa),循环两次,每次10 min,间隔10 min,最后一次处理后30 min同前造摸.③拮抗剂组:静脉给予蛋白激酶C拮抗剂chelerythrine 5mg/kg,1 h后造模.④预处理加拮抗剂组:预处理前30 min静脉注射chelerythrine 5 mg/kg,余同预处理组.再灌注后4,8,12,24和48h分别对动物后肢运动功能评分(Tarlov标准,0~4级,共5级,0级为后肢完全瘫痪,4级为运动功能正常).再灌注48 h,处死动物取脊髓(L5~7),计算脊髓前角正常神经元数.结果:经补充后28只动物进入结果分析.①脊髓前角正常神经元数:预处理组显著高于对照组、拮抗剂组和预处理加拮抗剂组(69,12,12,8个,P<0.01).②神经功能评分:预处理组在再灌注8 h后各时间点均明显高于对照组(P<0.01),预处理加拮抗剂组和拮抗剂组与对照组比较差异无显著性(P>0.05).③神经功能评分与脊髓前角正常运动神经细胞数之间有显著相关性(r=0.872,P<0.01).结论:蛋白激酶C拮抗剂chelerythrine能完全阻断下肢预处理对随后脊髓缺血的保护效应,提示蛋白激酶C参与了远程预处理诱导脊髓缺血耐受的形成机制. 相似文献
55.
Pham Thi Thu Huong Chan-Ho Lee Mei Hong Li Min Young Lee Joon-Ki Kim Sun-Mee Lee Jong-Heum Seon Dong-Cheol Lee Young Jin Jeon 《The Korean journal of physiology & pharmacology》2011,15(2):101-106
We demonstrate that glycoprotein isolated from Dioscorea batatas (GDB) has immunostimulatory effects including macrophage activation. Analysis of infiltration of inflammatory cells into peritoneal cavity showed GDB treatment significantly increased the recruitment of macrophages, lymphocytes, neutrophils, and monocytes into the peritoneal cavity. Treatment of spleen cells isolated from C57BL/6 mice with GDB significantly increased the proliferation of B cells and T cells induced by LPS and ConA, respectively. Treatment with GDB significantly increased the cytolytic capacity of NK cells and macrophages against YAC-1 and B16 cells, respectively. In order to further confirm and investigate the mechanism of GDB on macrophage activation, we analyzed the effects of GDB on the cytokine expression including iNOS, IL-1β, and TNF-α in mouse macrophage cell line, RAW 264.7 cells. RT-PCR and ELISA showed that GDB increased the expression of IL-1β, and TNF-α, whereas iNOS was not induced by GDB. Collectively, this series of experiments indicates that GDB stimulates immune system including macrophage activation. 相似文献
56.
Le Quoc Tuan Tran Thi Thanh Huong Pham Thi Anh Hong Tomonori Kawakami Toshinori Shimanouchi Hiroshi Umakoshi Ryoichi Kuboi 《Toxicology in vitro》2008,22(6):1632-1638
Arsenate is one of the most poisonous elements for living cells. When cells are exposed to arsenate, their life activities are immediately affected by various biochemical reactions, such as the binding of arsenic to membranes and the substitution of arsenic for phosphate or the choline head of phospholipids in the biological membranes. The effects of arsenate on the life activities of algae Chlorella vulgaris were investigated at various concentrations and exposure times. The results demonstrated that the living activities of algal cells (10(10)cells/L) were seriously affected by arsenate at a concentration of more than 7.5mg As/L within 24h. Algal cells and the artificial membranes (liposomes) were exposed to arsenate to evaluate its effects on the membrane fluidization. In the presence of arsenate, the membranes were fluidized due to the binding and substitution of arsenate groups for phosphates or the choline head on the their membrane surface. This fluidization of the biological membranes was considered to enhance the transport of toxicants across the membrane of algal cells. 相似文献
57.
Le Tran Ngoan Nguyen Thi Diep Anh Nguyen Thi Thanh Huong Nguyen Thi Thu Nguyen Thi Lua Lai Thi Minh Hang Nguyen Ngoc Bich Nguyen Van Hieu Ha Van Quyet Le Thi Tai Do Duc Van Nguyen Cong Khan Le Bach Mai Shinkan Tokudome Takesumi Yoshimura 《Asian Pacific journal of cancer prevention》2008,9(2):299-302
Background: The International Collaborative Epidemiological Study of Host and Environmental Factors for Stomach and Colorectal Cancers in Southeast Asian Countries (SEACs) has been conducted in Viet Nam from 2003 to 2008 on a case-control basis. For further effective primary prevention, we examined gastric and colorectal cancer mortality nationwide in eight regions of Viet Nam in 2005-06. Methods: Both demographic data and lists of all deaths in 2005-06 were obtained from all 10,769 commune health stations in Viet Nam. Five indicators included name, age, sex, date of death and cause of death was collected for each case. We selected only communes having the list of deaths with clear cause for each case and crude mortality rate for all causes from 300-600/100,000 as published by the Ministry of Health for a reasonable accuracy and completeness. Obtained data for all causes, all cancers, stomach and colorectal cancer deaths as well as demographic information were processed using Excel software and exported to STATA 8.0 for estimation of world age-standardized cancer mortality rates per 100,000. Results: Data were available for 1,246 gastric cases, (819 male and 427 female) with age-standardized mortality rates from 12.7 to 31.3 per 100,000 in males and from 5.9 to 10.3 per 100,000 in females in the 8 regions of the country. For colorectal cancers, 542 cases (268 male and 274 female) gave mortality rates from 4.0 to 11.3 per 100,000 in males and from 3.0 to 7.8 per 100,000 in females. Discussion: Stomach cancer mortality in males in the region of North East in the North Viet Nam (2005-06) was higher than that in Japan (2002) (31.3 versus 28.7 per 100,000) while colorectal cancer in Viet Nam was lower. While prevalence of Hp infection in Viet Nam was from 70-75% in both males and females, the stomach cancer rate in males was significantly higher than in females, 31.3 versus 6.8 per 100,000, suggesting an influence of other environmental risk factors. Whether protective factors are operating against colorectal cancer in Viet Nam now needs to be explored. 相似文献
58.
59.
A methanol extract of Zanthoxylum schinifolium stems at a concentration of 250 microg/ml showed potent inhibitory activity against monoamine oxidase (MAO) in a mouse brain. Activity-guided separation and purification of the extract yielded lacinartin (1) as an active coumarin compound. Lacinartin showed significant inhibitory effects on MAO in a dose-dependent manner. The IC(50) value on MAO activity was 9.2 microM. The MAO-A (IC(50) value, 5.7 microM) sensitivity to lacinartin was greater than that of MAO-B (IC(50) value, 28.6 microM). An enzyme kinetic study revealed that lacinartin inhibited MAO activity by a non-competitive mode. 相似文献
60.
Risk of ovarian failure and fertility after intravenous cyclophosphamide. A study in 84 patients 总被引:10,自引:0,他引:10
Huong DL Amoura Z Duhaut P Sbai A Costedoat N Wechsler B Piette JC 《The Journal of rheumatology》2002,29(12):2571-2576
OBJECTIVE: To compare the risk of ovarian failure and the fertility of women treated with intravenous cyclophosphamide (IVCY) according to the underlying inflammatory disease. METHODS: Review of the data of 84 consecutive women: 56 with systemic lupus erythematosus (SLE), 28 with other diseases, mainly Wegener's granulomatosis and systemic vasculitides. RESULTS: The mean age at IVCY initiation was 29 +/- 10 years (range 13-53). The mean dosage was 0.9 +/- 0.14 g per pulse (range 0.5-1), and the mean number of pulses 13 +/- 6.5 (range 3-42). With a mean followup of 5.1 +/- 3.7 years, 23 women developed amenorrhea, with a mean duration of 4 +/- 3.6 months between IVCY initiation and amenorrhea. Amenorrhea was sustained in 19 women (13 with SLE and 6 with other diseases, NS). The mean age at ovarian failure onset was 40 +/- 7.6 years. The risk of ovarian failure correlated with the age at IVCY institution (p < 0.0001), and was independent of underlying inflammatory disease. Eighteen women (13 with SLE and 5 with other diseases) became pregnant during or after CY therapy, with a total of 22 pregnancies. The mean age at IVCY initiation, and the mean number of IVCY (maximum 40 pulses) before pregnancy were similar in women with SLE and those with other diseases. Six pregnancies occurred during IVCY therapy, which ended in induced abortion (n = 3), spontaneous abortion (n = 1), and normal pregnancy after IVCY withdrawal (n = 2) in women who wished to keep their pregnancy despite the risk of teratogenicity. Sixteen pregnancies occurred 2.9 +/- 2.1 years (range 1-9) after IVCY withdrawal. They ended in: 3 induced abortions indicated for severe morphological anomalies (n = 2) and for SLE relapse (n = 1), 3 spontaneous miscarriages, and 10 deliveries of healthy newborns. CONCLUSION: The risk of ovarian failure depends essentially on the age at IVCY initiation. Pregnancy may occur during IVCY therapy, and an efficient contraception is mandatory. After IVCY withdrawal, pregnancy is possible with a favorable outcome in two-thirds of the cases. 相似文献