全文获取类型
收费全文 | 1617篇 |
免费 | 82篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 38篇 |
妇产科学 | 32篇 |
基础医学 | 242篇 |
口腔科学 | 161篇 |
临床医学 | 71篇 |
内科学 | 300篇 |
皮肤病学 | 10篇 |
神经病学 | 170篇 |
特种医学 | 50篇 |
外科学 | 295篇 |
综合类 | 14篇 |
预防医学 | 116篇 |
眼科学 | 20篇 |
药学 | 95篇 |
中国医学 | 9篇 |
肿瘤学 | 65篇 |
出版年
2023年 | 10篇 |
2022年 | 23篇 |
2021年 | 40篇 |
2020年 | 29篇 |
2019年 | 22篇 |
2018年 | 39篇 |
2017年 | 32篇 |
2016年 | 45篇 |
2015年 | 59篇 |
2014年 | 51篇 |
2013年 | 93篇 |
2012年 | 145篇 |
2011年 | 148篇 |
2010年 | 81篇 |
2009年 | 77篇 |
2008年 | 126篇 |
2007年 | 133篇 |
2006年 | 100篇 |
2005年 | 102篇 |
2004年 | 82篇 |
2003年 | 83篇 |
2002年 | 68篇 |
2001年 | 3篇 |
2000年 | 5篇 |
1999年 | 4篇 |
1998年 | 8篇 |
1997年 | 6篇 |
1996年 | 6篇 |
1995年 | 4篇 |
1994年 | 7篇 |
1993年 | 2篇 |
1992年 | 4篇 |
1991年 | 4篇 |
1990年 | 5篇 |
1989年 | 4篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1984年 | 5篇 |
1980年 | 4篇 |
1978年 | 3篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1973年 | 3篇 |
1972年 | 6篇 |
1969年 | 5篇 |
1968年 | 2篇 |
1964年 | 2篇 |
1959年 | 2篇 |
1946年 | 1篇 |
排序方式: 共有1703条查询结果,搜索用时 10 毫秒
91.
In late 2004 the Constitutional Court of Colombia ordered that a woman living with HIV be reinstated in her job at a health clinic in order to respect her rights under the national constitution, pending a final determination of the merits of her claim of discrimination and other infringement of human rights. 相似文献
92.
93.
Oral myiasis is a rare pathology and a risk to the patient's life. Conventional treatment is mechanical removal of the larvae (maggots) one by one, which is painful, distressing, and embarrassing both to the patient and to the dentist. We present a case report of a patient with cerebral palsy that had oral myiasis treated successfully with ivermectin. The use of this antibiotic in humans, its mechanism of action and indications are discussed. 相似文献
94.
Corti ME Yampolsky C Metta H Valerga M Sevlever G Capizzano A 《Revista do Instituto de Medicina Tropical de S?o Paulo》2004,46(4):195-197
In the last years, new techniques of neuroimages and histopathological methods have been added to the management of cerebral mass lesions in patients with AIDS. Stereotactic biopsy is necessary when after 14 days of empirical treatment for Toxoplasma gondii encephalitis there is no clinical or neuroradiologic improvement. We report a woman with AIDS who developed a single focal brain lesion on the right frontal lobe. She presented a long history of headache and seizures. After two weeks of empirical treatment for toxoplasma encephalitis without response, a magnetic resonance image with spectroscopy was performed and showed a tumoral pattern with a choline peak, diminished of N-acetyl-aspartate and presence of lactate. A stereotactic biopsy was performed. Histopathological diagnosis was a diffuse oligodendroglioma type A. A microsurgical resection of the tumor was carried out and antiretroviral treatment was started. To date she is in good clinical condition, with undetectable plasma viral load and CD4 T cell count > 200 cell/uL. 相似文献
95.
96.
97.
Palou J Vicente J Segarra J Huguet J Salvador J Villavicencio H 《Archivos espa?oles de urología》2004,57(3):291-297
Since Pérez-Castro and Martínez-Pi?eiro initiated diagnostic and therapeutic ureteroscopy this technique has gained a place in the management of upper urinary tract tumors. Improvement of the equipment (rigid and flexible), better diagnosis and knowledge of outcomes and allows to treat a group of patients with transitional cell carcinoma of the ureter and pelvis by the conservative retrograde technique. In this article, we present an overview of indications and management of the upper urinary tract tumor by ureteroscopy. 相似文献
98.
Al-Shraim M Syro LV Kovacs K Estrada H Uribe H Al-Gahtany M 《Surgical neurology》2004,62(3):264-7; discussion 267
BACKGROUND: Inflammatory pseudotumor of the pituitary is a very rare nonneoplastic lesion. We describe a case of a patient with past history of lymphocytic meningitis. CASE DESCRIPTION: A 32-year-old man presented with polyuria, polydipsia, anorexia, abdominal discomfort, and panhypopituitarism. He had 2 episodes of lymphocytic meningitis in the last two years. Magnetic resonance image (MRI) disclosed a sellar and suprasellar mass with extension to the pituitary stalk. The patient underwent transnasal-transsphenoidal surgery to remove the lesion. Histopathological findings revealed mixed inflammatory cells composed mainly of lymphocytes, macrophages and extensive fibrosis. CONCLUSIONS: Inflammatory pseudotumor of the pituitary, although rare, should be included in the differential diagnosis of a sellar and suprasellar mass. 相似文献
99.
Tabernero J Paz-Ares L Salazar R Lianes P Guerra J Borrás J Villavicencio H Leiva O Cortés-Funes H 《The Journal of urology》2004,171(1):164-167
PURPOSE: The crude and cumulative incidence of contralateral germ cell testicular tumors (GCTTs) is between 1% to 5% and 3% to 6% at 10 to 15 years in previously reported studies. To evaluate the real incidence of a second GCTT in a southern European population the medical records of 623 patients with GCTT successfully treated between 1976 and 1993 at 2 university hospitals were reviewed. MATERIALS AND METHODS: All patients had been treated with standard treatment strategies according to disease stage and diagnosis year. Contralateral biopsy at GCTT diagnosis was not performed in any patient. Only those with a survival of 1 year or greater were included. In addition to the imaging and biochemical (tumor markers) procedures used to diagnose disease relapse, physical examination of the contralateral testis and/or testicular ultrasound was done yearly. RESULTS: At a median followup of 8.6 years (range 2 to 19.7) 6 patients (1%) had a contralateral GCTT, which was synchronous in 1 and metachronous in 5. The cumulative risk of a contralateral GCTT was 1.2% (95% CI 0.1% to 2.3%) at 15 years and it did not depend on the treatment for the first GCTT. CONCLUSIONS: The incidence of contralateral GCTT in our series was lower than expected compared with other published series. This finding mirrors the lower incidence of GCTT in the general population in our country than in other areas with a higher incidence of contralateral GCTT. Therefore, contralateral testicular biopsy at initial diagnosis is not mandatory in our experience. 相似文献
100.
Fu T Blei AT Takamura N Lin T Guo D Li H O'Gorman MR Soriano HE 《Cell transplantation》2004,13(6):667-676
Apoptosis occurs during the isolation and even short-term storage and culture of hepatocytes, and in the pathogenesis of liver diseases, such as hepatic failure and hepatitis. Therapeutic hypothermia has beneficial effects in experimental models of fulminant hepatic failure. The mechanisms underlying the potential benefits of mild hypothermia on the liver have not been well investigated. We examined the effects of temperature on soluble Fas ligand-induced apoptosis in freshly isolated mouse hepatocytes. Decreasing the culture temperature from 37 degrees C to 32 degrees C produced significant suppression of Fas-mediated apoptosis in cultured hepatocytes over a 12-h period. This observation was supported by cell morphology, flow cytometry analysis of cellular DNA content, and Annexin V-FITC staining of membrane phosphatidylserine translocation. In hypothermic conditions, Fas-mediated cytochrome c release from mitochondria of hepatocytes and the proximate downstream activation of caspase-9 were suppressed under mild hypothermic conditions. Effector caspase-7 activity was also inhibited at 32 degrees C. In contrast, the activation of initiator caspase-8 and cleavage of Bid were not affected after Fas-ligand stimulation. These findings suggest that mild hypothermia suppresses Fas-mediated apoptosis of liver cells by the partial inhibition of signaling events including mitochondrial damage, cytochrome c release, and subsequent apoptosome formation and effector caspase activation. 相似文献