Study on "massage to activate the meridian" apparatus in the treatment of cholecystolithiasis

This apparatus is designed in accordance with the doctrine and principles of traditional Chinese medicine and based on the theory of meridian and specific massage procedure in conjunction with the "Information Theory" and electron utilizing technique. It utilizes a programmed induction "Special Wave" to stimulate a series of acupuncture points, combined with administration of western drugs from a regime of "General Attack" treatment on the gallbladder stones, to enhance their evacuation. By stimulating the specific acupuncture points with this apparatus through the action of "Special Wave" strong contraction of the gallbladder can be elicitated. Experiments on dogs showed that under such stimulation the intra-gallbladder pressure can be increased 26 times, producing a jet of bile flow which facilitates the expulsion and evacuation of stones in the gallbladder. Method of use: first place a conductive rubber pad on the acupuncture point to be stimulated, then use a hand-held electrode to massage-stimulate the meridian. It is carried out forward and backward along the direction of meridian. The whole procedure is carried out under direct visualization with the help of ultrasonic B-scan. When dilatation of the common bile duct is observed, the hand-help electrode is used to perform push-compress massage on the meridian, and acupuncture points making the stones enter the common bile duct B-scan give proper orientation for the manipulation. This method has been tested clinically on 410 patients with good results. The evacuation rate of the gallbladder stones was 92.7% with complete evacuation achieved in 17.3%.(ABSTRACT TRUNCATED AT 250 WORDS)     

左心室局部心肌梗塞时的组分式模型及计算机仿真

为研究左心室局部心肌梗塞时心肌各部分的能量供需状况及心脏辅助装置对改善心肌能量供给的影响，我们建立了一个由左心室正常区域心肌和梗塞区域心肌两部分组成的组分式模型，我们的模型以Ｓｕｎａｇａｗａ的模型为基础，并在此基础上加以扩展，与Ｓｕｎａｇａｗａ的模型相比，我们的模型允许梗塞区域心肌的收缩性在一定范围内变化，从而可以模拟各种不同范围和不同程度的梗塞情况。用建立好的左心室组分式模型取代我们原有的狗的心     

蝎蜂毒肽对大鼠纤溶系统作用初探

本研究采用大鼠肢体血管灌流和整体给药两种模型，观察蝎蜂毒（ＳＢＰ）对血管理灌流液内纤溶酶原激活物（ＰＡ）活性、血浆优球蛋白纤溶性（ＥＦＡ）和纤溶酶（ＰＬ）活性的影响。结果说明，ＳＢＰ有明显激活纤溶系统作用；其机制可能涉及血管内皮细胞释放ＰＡ活性增加，进一步促使纤溶酶原活化为ＰＬ增多的途径。     

Functional tyrosine kinase inhibitor profiling: a generally applicable method points to a novel role of platelet-derived growth factor receptor-beta in tuberous sclerosis

A ubiquitous herpesvirus that establishes life-long infection, the Epstein-Barr virus (EBV) has yielded little insight into how a single agent in general accord with its host can produce diverse pathologies ranging from oral hairy leukoplakia to nasopharyngeal carcinoma, from infectious mononucleosis to Hodgkin's disease (HD) and Burkitt's lymphoma. Its pathogenesis is further confounded by the less than total association of virus with histologically similar tumors. In other viral systems, defective (interfering) viral genomes are known to modulate outcome of infection, with either ameliorating or intensifying effects on disease processes initiated by prototype strains. To ascertain whether defective EBV genomes are present in HD, we examined paraffin-embedded tissue from 56 HD cases whose EBV status was first determined by cytohybridization for nonpolyadenylated EBV RNAs (EBERs). Using both standard polymerase chain reaction (PCR) and PCR in situ hybridization, we successfully amplified sequences that span abnormally juxtaposed BamHI W and Z fragments characteristic of defective heterogeneous (het) EBV DNA from 10 of 32 (31%) EBER-positive tumors. Of 24 EBER-negative HD, 8 yielded PCR products indicating presence of het EBV DNA. Two of these contained defective EBV in the apparent absence of the prototype virus. Of the 42 tumors analyzed for defective EBV by both PCR techniques, there was concordance of results in 38 (90%). Detection of defective EBV genomes with the potential to disrupt viral gene regulation suggests one mechanism for pathogenic diversity that may also account for loss of prototypic EBV from individual tumor cells.     

Cytogenetic and molecular cytogenetic studies of a case of interstitial deletion of proximal 15q

A 4-month-old child with multiple anomalies was determined to have an interstitial deletion of chromosome 15, i.e., del(15) (q12q14). The deletion appears not to be a typical deletion of 15q12 such as seen in Angelman and Prader-Willi syndromes, but appears to be more distal, involving either loss of all of 15q12 and part of 15q14, or part of 15q12 and most of 15q14. In either case, 15q13 is missing. Fluorescent in situ hybridization with probes for 15 centromere (D15Z), pericentromeric satellite sequences (D15Z1), and chromosome 15 painting probes shows the deleted chromosome to involve only 15 and no other acrocentric chromosome. Hybridization with probes for the AS and PWS loci (D15S11 and GABAB3, Oncor) show both sites to be intact in the deleted 15. The case is compared with two other reports with overlapping interstitial deletions of proximal 15q, neither of which shows typical features of Angelman or Prader-Willi syndromes.     

骨折愈合塑形的力学机理I^＊——骨表面再造理论的应用

深入探讨长骨骨折愈合塑形阶段的力学机理,采用骨表面再造理论与有限元结合的方法。我们选取用应变能密度作为力学激励的骨表面再造理论,有限元分析采用三维的空间模型,利用我们编制的长骨表面再造系统“BRSS97”对长骨骨折愈合塑形阶段的三种类型：外骨痂型、骨内缺损型和骨外缺损型的力学机理进行研究。结果表明：骨痂可以完全吸收,骨缺损可以恢复,三种情况下骨均可以恢复到正常状态。由此说明长骨骨折愈合塑形过程就是骨材料对力学激励的适应过程。     

慢性乙肝患者NK,ADCC活性及其对IFN—α,IFN—γ的反应

本文用Hela细胞乳酸脱氢酶释放法测定了42例慢性乙肝病人外周血NK、ADCC活性及其对IFN-α100U/ml、500U/ml及IFN-γ500U/ml预处理4小时后的反应。结果显示,病人PBL NK,ADCC活性与正常对照有显著差别,经IFNs处理后,其NK或/和ADCC活性均有不同程度的升高反应,从而提示了IFNs在慢性肝病治疗中的重要作用。     

空肠弯曲菌HSP43诱导自身免疫机理──分子模拟和抗原优势

我们曾发现空肠弯曲菌４３ｋＤ热休克蛋白（ＨＳＰ４３）能诱导小鼠产生自身免疫应答，本文则进一步分析了这种诱导作用的机理。二株针对ＨＳＰ６０保守区序列的单克隆抗体ＩＩＨ９和ＭＬ－３０不但能结合人及小鼠细胞中ＨＳＰ６０家族成员，而且也能结合ＨＳＰ４３，表明ＨＳＰ４３、人及小鼠ＨＳＰ６０三者均属同一家族成员，具有序列上的高度同源性。小鼠用空肠弯曲菌免疫后出现了针对１０种菌体蛋白的抗体，其中最早被诱导的抗体是针对ＨＳＰ４３的，并且该种抗体在随后８０ｄ观察期间内保持了较高活性，表明ＨＳＰ４３是优势抗原。本文结果提示，ＨＳＰ４３较易被免疫系统识别而产生应答，通过和宿主ＨＳＰ６０高度序列同源性而可能呈现分子模拟，从而诱导自身免疫损伤。