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31.
Study on the Relationship between Insulin-Resistance and Syndrome Differentiation Typing in Hypertension Patients 下载免费PDF全文
Hypertensionisacommondiseaseofcar diovascularsysteminChina,butitspathogen esishasnotbeenyetfullyexplained.Inrecentyears,thecorrelationbetweeninsulin resis tanceandhypertensionhasdrawnextensiveattentionfrommedicalresearchers.Eversince1 988whenReaven(1) rai… 相似文献
32.
Chi-Jung Chung Yeong-Shiau Pu Chien-Tien Su Hui-Wen Chen Yung-Kai Huang Horng-Sheng Shiue Yu-Mei Hsueh 《Cancer causes & control : CCC》2010,21(10):1605-1613
Background
Gene polymorphisms in the one-carbon metabolism pathway could contribute to arsenic methylation capability through plasma folate and homocysteine metabolism, thereby increasing the susceptibility to urothelial carcinoma (UC) risk. 相似文献33.
为探讨儿童急性淋巴细胞白血病初诊时TEL-AML1融合基因表达水平与患儿的临床特点、早期治疗反应的关系,采用实时定量聚合酶链反应(RQ-PCR)定量检测35例患儿(包括标危20例,中危15例)初诊TEL-AML1表达水平和诱导缓解治疗结束微小残留病(MRD)水平,比较MRD阴性与MRD阳性患儿的初诊TEL-AML1表达水平及临床特点,分析初诊TEL-AML1表达水平、MRD水平与临床特点、早期治疗反应的相关性。结果发现,初诊时TEL-AML1表达水平为1.63×104拷贝/104拷贝ABL(中位数)。诱导缓解结束时,16例(10例标危、6例中危)患儿未达到分子缓解,MRD水平分别为0.84-282.93拷贝/104拷贝ABL。初诊TEL-AML1表达水平与各临床特点及MRD水平缺乏相关性。MRD水平与泼尼松实验治疗第8天外周血幼稚细胞数显著相关。初诊时外周血白细胞计数〈25×109/L的患儿,MRD水平还与白细胞计数、幼稚细胞百分比显著相关。MRD阴性患儿初诊TEL-AML1表达水平显著低于MRD阳性者。结论:对于TEL-AML1+儿童ALL,45.71%未能在诱导缓解治疗结束时获得分子缓解,说明了后续治疗的重要性。泼尼松实验治疗的效果预示了诱导缓解治疗结束时的MRD水平。初诊外周血白细胞计数、幼稚细胞百分比和初诊TEL-AML1表达水平均在一定程度上影响诱导缓解治疗结束时的MRD水平。 相似文献
34.
Nian-Sheng Tzeng Chi-Hsiang Chung Feng-Cheng Liu Yu-Hsiang Chiu Hsin-An Chang Chin-Bin Yeh San-Yuan Huang Ru-Band Lu Hui-Wen Yeh Yu-Chen Kao Wei-Shan Chiang Chang-Hui Tsao Yung-Fu Wu Yu-Ching Chou Fu-Huang Lin Wu-Chien Chien 《The American journal of the medical sciences》2018,355(2):153-161
Background
Fibromyalgia is a syndrome of chronic pain and other symptoms and is associated with patient discomfort and other diseases. This nationwide matched-cohort population-based study aimed to investigate the association between fibromyalgia and the risk of developing dementia, and to clarify the association between fibromyalgia and dementia.Materials and Methods
A total of 41,612 patients of age ≥50 years with newly diagnosed fibromyalgia between January 1, and December 31, 2000 were selected from the National Health Insurance Research Database of Taiwan, along with 124,836 controls matched for sex and age. After adjusting for any confounding factors, Fine and Gray competing risk analysis was used to compare the risk of developing dementia during the 10 years of follow-up.Results
Of the study subjects, 1,704 from 41,612 fibromyalgia patients (21.23 per 1,000 person-years) developed dementia when compared to 4,419 from 124,836 controls (18.94 per 1,000 person-years). Fine and Gray competing risk analysis revealed that the study subjects were more likely to develop dementia (hazard ratio: 2.29, 95% CI: 2.16-2.42; P < 0.001). After adjusting for sex, age, monthly income, urbanization level, geographic region of residence and comorbidities the hazard ratio was 2.77 (95% CI: 2.61-2.95, P < 0.001). Fibromyalgia was associated with increased risk of all types of dementia in this study.Conclusions
The study subjects with fibromyalgia had a 2.77-fold risk of dementia in comparison to the control group. Therefore, further studies are needed to elucidate the underlying mechanisms of the association between fibromyalgia and the risk of dementia. 相似文献35.
36.
Chung-Ji Liu Wan-Jung Chang Chang-Yi Chen Fang-Ju Sun Hui-Wen Cheng Tsai-Ying Chen Shu-Chun Lin Wan-Chun Li 《Oncotarget》2015,6(30):29268-29284
Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent neoplasms worldwide. While numerous potent dietary insults were considered as oncogenic players for HNSCC development, the impact of metabolic imbalance was less emphasized during HNSCC carcinogenesis. Previous preclinical and epidemiological investigations showed that DM could possibly be correlated with greater incidence and poorer prognosis in HNSCC patients; however, the outcomes from different groups are contradictive and underlying mechanisms remains elusive. In the present study, the changes of cellular malignancy in response to prolonged glucose incubation in HNSCC cells were examined. The results demonstrated that hyperglycemia enhanced HNSCC cell malignancy over time through suppression of cell differentiation, promotion of cell motility, increased resistance to cisplatin, and up-regulation of the nutrient-sensing Akt/AMPK-mTORC1 pathway. Further analysis showed that a more aggressive tongue neoplastic progression was found under DM conditions compared to non-DM state whereas DM pathology led to a higher percentage of cervical lymph node metastasis and poorer prognosis in HNSCC patients. Taken together, the present study confirms that hyperglycemia and DM could enhance HNSCC malignancy and the outcomes are of great benefit in providing better anti-cancer treatment strategy for DM patients with HNSCC. 相似文献
37.
Spike protein fusion peptide and feline coronavirus virulence 总被引:1,自引:0,他引:1
Chang HW Egberink HF Halpin R Spiro DJ Rottier PJ 《Emerging infectious diseases》2012,18(7):1089-1095
Coronaviruses are well known for their potential to change their host or tissue tropism, resulting in unpredictable new diseases and changes in pathogenicity; severe acute respiratory syndrome and feline coronaviruses, respectively, are the most recognized examples. Feline coronaviruses occur as 2 pathotypes: nonvirulent feline enteric coronaviruses (FECVs), which replicate in intestinal epithelium cells, and lethal feline infectious peritonitis viruses (FIPVs), which replicate in macrophages. Evidence indicates that FIPV originates from FECV by mutation, but consistent distinguishing differences have not been established. We sequenced the full genome of 11 viruses of each pathotype and then focused on the single most distinctive site by additionally sequencing hundreds of viruses in that region. As a result, we identified 2 alternative amino acid differences in the putative fusion peptide of the spike protein that together distinguish FIPV from FECV in >95% of cases. By these and perhaps other mutations, the virus apparently acquires its macrophage tropism and spreads systemically. 相似文献
38.
Yamashita-Kawanishi Nanako Gushino Yuuka Chang Chia-Yu Chang Hui-Wen Chambers James K. Uchida Kazuyuki Haga Takeshi 《Virus genes》2021,57(4):380-384
Virus Genes - The present study describes two full-genome sequences of Felis catus papillomavirus type 4 (FcaPV4) identified in squamous cell carcinoma (SCC) of two domestic cats. Two full-genome... 相似文献
39.
Chun-Kuang Shih Chiao-Ming Chen C.-Y. Oliver Chen Jen-Fang Liu Hui-Wen Lin Hung-Tsung Chou Sing-Chung Li 《Food and chemical toxicology》2010
Riboflavin (vitamin B2) is a water-soluble vitamin essential for normal cellular functions, growth and development. This study aimed to investigate the effects of vitamin B2 on the survival rate, and expressions of tissue heat shock protein 25 (HSP25) and heat shock factor 1 (HSF1) in mice undergoing lipopolysaccharide (LPS) induced shock. Mice were assigned to four groups, saline vehicle, LPS, LPS plus low dose of vitamin B2 (LB2) and LPS plus high dose of vitamin B2 (HB2). Vitamin B2 (1 and 10 mg/kg BW) was administered intraperitoneally at 2 and 0 h before the i.p. administration of LPS. At the end of the experiment, the survival rate monitored was 10, 20, 60, and 100% for LPS, LB2, HB2, and saline mice, respectively. HSP25 expressions in the heart and lung were significantly enhanced in a time-dependent manner in the HB2 mice as compared to the saline mice (p < 0.05), but not altered in the LB2 mice. In the HB2 mice, plasma riboflavin concentrations reached 300 nM at 6 h post LPS and returned to the 0 h level at 72 h. The results showed that high dose of riboflavin could decrease LPS-induced mortality through an increased expression of HSP25. 相似文献
40.
硫酸地贝卡星在碱性条件下与丙酮及亚硝基铁氰化钠反应生成紫红色产物,选择515nm、565nm和615nm进行三波长法测定能有效排除背景干扰,在0.1-1.4mg/ml浓度范围内线性关系良好,平均回收率99.8%,方法简例、快速、准确。 相似文献