实现人才集聚效应的实践与评价

该文参照人才集聚效应评价指标体系,从集聚规模、人才结构、人才流动、人才成长、虚拟人才、人才使用、人才创新、人才联动、人才吸引力、人才满意度等10个方面,对比2003年末与2009年末南京市妇幼保健院人才状况的变,分析医院人才现象产生的机制,评价医院人才效应实现的程度与价值.     

结肠癌局部外侵的SCT与手术病理对照研究

目的　研究SCT增强扫描判断结肠癌局部外侵的准确性。方法　 32例结肠癌患者术前 1周内行腹部CT平扫与SCT增强扫描 ,并测原发病灶与局部肠周围脂肪间隙内异常软组织影的强化值 ,与原发病灶有相同或相近强化程度的判断为癌组织浸润。SCT结果与手术病理结果对比。结果　 2例结肠癌侵犯相邻结构 ,CT准确显示。 19例原发病灶与 40个相邻结构粘连 ,SCT增强扫描判断有癌浸润的 2 8个 ,病理结果为 2 5个。结论　SCT增强扫描判断结肠癌局部外侵的准确率为 92 .5 % ,基本可反应癌组织局部外侵的实际情况。     

Association of Air Pollution with Hospital Outpatient Visits in Beijing

Data collected at a community-based hospital in Beijing, China, were analyzed in an assessment of the association of air pollution with daily outpatient visits. Total suspended particle (TSP) measurements were available for 210 d (mean, 388 μg/m³; maximum, 1 255 μg/m³), and sulfur dioxide (SO₂) measurements were available for 2 d (mean, 119 μg/m³; maximum, 478 μg/m³). The average number of daily hospital outpatient visits was 1 386; approximately 8.5% of these visits were to the surgery department, 7.9% were to the pediatrics department, and 20.6% were to the internal medicine department. A large increase in nonsurgery outpatient visits was observed in association with increases in both SO₂, and TSP in linear regression models, after adjusting for temperature, humidity, season, and day of the week. The estimated effects (in which the most polluted days were compared with the least polluted days) on nonsurgery outpatient visits were increases of 20% (SE = 5%) and 17% (SE = 4%) in association with increases in SO₂ and TSP, respectively. In a department-specific analysis, the association was found to be 1.5- to 2.0-fold stronger for pediatrics and internal medicine visits than for other types of visits. The separate associations of SO₂ and TSP with internal medicine visits remained statistically significant when both SO₂, and TSP were considered simultaneously and when adjustment was made for surgery visits. SO₂ and TSP were found to be significant, independent predictors of internal medicine visits in both winter and summer. The association between outpatient visits and air pollution appeared to be stronger in summer than in winter, although the summer daily mean SO₂ concentration was only 17 μg/m3 (maximum, 51 μg/m³). These data, together with data obtained in previous studies, provide coherent evidence that current air-pollution levels in Beijing are associated with adverse health outcomes, and they also suggest that air pollution in Beijing needs to be controlled more effectively.     

天麻素注射液联合盐酸氟西丁治疗卒中后抑郁的临床效果观察

目的 探讨天麻素注射液联合盐酸氟西丁治疗卒中后抑郁的临床效果及安全性.方法 对符合条件的102例卒中后抑郁患者随机分为两组,每组51例,天麻素注射液(600 mg,1次/d,静脉滴注,疗程14 d)联合盐酸氟西丁(20 mg,1次/d,口服,30 d)组为治疗组.单用盐酸氟西丁(20 mg,1次/d,口服,30 d)为对照组.观察两组患者的症状及体征变化以及汉密尔顿抑郁量表评分,评价疗效.结果 治疗组痊愈9.8％ (5/51),显著进步52.9％ (27/51),进步27.5％(14/51),无效9.8％ (5/51),总有效率90.2％ (46/51).对照组痊愈2.0％(1/51),显著进步11.7％ (6/51),进步66.7％ (34/51),无效19.6％(10/51),总有效率80.4％ (41/51).治疗组的疗效优于对照组,二者比较差异有统计学意义(x2=13.03,P＜0.05).治疗组不良反应发生率为3.92％ (2/51),对照组为25.5％(13/51),两组比较差异有统计学意义(x2=9.64,P＜0.01).结论 天麻素注射液联合盐酸氟西丁是治疗卒中后抑郁的一种疗效确切且副反应少的治疗方法.     

Staphylococcus aureus Formyl-Methionyl Transferase Mutants Demonstrate Reduced Virulence Factor Production and Pathogenicity

Inhibitors of peptide deformylase (PDF) represent a new class of antibacterial agents with a novel mechanism of action. Mutations that inactivate formyl methionyl transferase (FMT), the enzyme that formylates initiator methionyl-tRNA, lead to an alternative initiation of protein synthesis that does not require deformylation and are the predominant cause of resistance to PDF inhibitors in Staphylococcus aureus. Here, we report that loss-of-function mutations in FMT impart pleiotropic effects that include a reduced growth rate, a nonhemolytic phenotype, and a drastic reduction in production of multiple extracellular proteins, including key virulence factors, such as α-hemolysin and Panton-Valentine leukocidin (PVL), that have been associated with S. aureus pathogenicity. Consequently, S. aureus FMT mutants are greatly attenuated in neutropenic and nonneutropenic murine pyelonephritis infection models and show very high survival rates compared with wild-type S. aureus. These newly discovered effects on extracellular virulence factor production demonstrate that FMT-null mutants have a more severe fitness cost than previously anticipated, leading to a substantial loss of pathogenicity and a restricted ability to produce an invasive infection.     

Development and Psychometric Testing of the Suicidal Recovery Ability Scale (SRAS) for Assessing Individuals Who Have Attempted Suicide

Assessing the recovery ability of individuals who have attempted suicide is crucial for psychiatric health nurses. The purpose of this study was to develop and test a psychometric Suicidal Recovery Ability Scale (SRAS). Confirmatory factor analysis (CFA) indicated that three subscales with 15 items best fit the data. The global SRAS score showed significant negative correlation with the Beck Hopelessness Scale (BHS) score. The Cronbach’s α and test-retest reliability scores for the global SRAS and the subscales all exceeded 0.70. Nurses can use the SRAS to assess the recovery ability of individuals who have attempted suicide and provide proper care to help them.