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81.
Synergism of atenoloi and nitrendipine on hemodynamic amelioration and organ protection in hypertensive rats
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OBJECTIVE: This study was designed to investigate the possible synergism of atenolol and nitrendipine on blood pressure (BP) and blood pressure variability (BPV) reductions, baroreflex sensitivity (BRS) amelioration, and organ protection in hypertensive rats. METHOD: The dose was 20 mg/kg for atenolol, 10 mg/kg for nitrendipine and 20 + 10 mg/kg for the combination of these two drugs. In an acute study, a single dose was given via a catheter previously inserted into the stomach in spontaneously hypertensive rats (SHR). 相似文献
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Dietary energy restriction was previously shown to be effective in
preventing a wide range of experimentally induced cancers. Studies were
conducted to assess the influence on pancreatic carcinogenesis of dietary
energy restrictions (reduced fat and carbohydrate) of 10%, 20% or 40% in
comparison with control in Syrian hamsters treated with N-
nitrosobis(2-oxopropyl)amine (BOP). Two carcinogenesis studies were
conducted. One used a single treatment with 20 mg BOP/kg body weight and
followed hamsters for 102 weeks following treatment, and the other used
three weekly treatments of 20 mg BOP/kg body weight and followed hamsters
for 45 weeks after treatment. Hamsters were fed control or energy
restricted diet beginning the week following the last BOP treatment.
Pancreatic carcinomas were induced in 9-18% of the hamsters in the first
experiment and in 59-66% of the animals in the second. Dietary energy
restriction did not influence carcinoma incidence in either study, and in
the second experiment the multiplicity of tumors was higher in the 40%
energy restriction (ER) group than in control hamsters. Plasma
corticosterone was suppressed by BOP treatment, particularly in the 20% and
40% ER hamsters in the second experiment, and diet or BOP treatment did not
significantly alter plasma cortisol. Pancreatic protein kinase Czeta
measured by Western blot was highest in the cytosol and particulate
fractions of the 40% ER hamsters in the first experiment. These results
indicate that dietary energy restriction is not effective in the prevention
of BOP induced pancreatic carcinogenesis in the Syrian hamster.
相似文献
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AS Siddiqui MBBS DF D'Costa MRCP B Moore-Smith FRCP 《International journal of clinical practice》1993,47(5):268-268
SUMMARY Hypothyroidism may present with weight gain and/or cardiovascular manifestations such as bradycardia or cardiac failure, but has not previously been documented as presenting with atrial fibrillation and weight loss. Our case highlights the importance of thyroid function tests in heart failure and emphasises the importance of regular follow-up after irradiation to the thyroid. 相似文献
87.
Abdominal computed tomography (CT) scans of 55 patients who had ingested Gastrografin (meglumine diatrizoate and diatrizoate sodium) diluted to 2% with tap water and flavored with a commercial fruit juice base were reviewed. Twenty patients (36%) demonstrated intraluminal precipitation of Gastrografin shown by focal areas of markedly increased attenuation within the gastric lumen or trapped within gastric folds. Beam-hardening artifact produced by precipitation was observed, which limited the diagnostic value of some examinations. In vitro CT scans of the same Gastrografin solution titrated with hydrochloric acid or sodium hydroxide showed that by raising the pH of the solution, precipitation was virtually eliminated. Fifty-one CT scans of the abdomen using a buffered Gastrografin solution demonstrated precipitation in only five patients. Properly buffered dilute oral Gastrografin solutions should significantly decrease the prevalence of precipitation during abdominal CT examinations. 相似文献
88.
Experiences of the first 493 unrelated marrow donors in the National Marrow Donor Program 总被引:5,自引:2,他引:3
Stroncek DF; Holland PV; Bartch G; Bixby T; Simmons RG; Antin JH; Anderson KC; Ash RC; Bolwell BJ; Hansen JA 《Blood》1993,81(7):1940-1946
More than 410,000 people participated in the National Marrow Donor Program (NMDP) as of October 1, 1991, and more than 850 volunteers had donated marrow. While the incidence of serious morbidity as a result of bone marrow donation is rare, the incidence of lesser complications and the long-term consequences of marrow donation are not known. To determine the incidence of donor complications and measure the recovery time of volunteer, unrelated marrow donors, we analyzed the results of surveys of the first 493 persons who donated marrow through the NMDP. The marrows were collected at 42 centers. The median age of the donors was 37.9 years (range 19.1 to 55.6 years). The median volume of marrow collected was 1,050 mL (range 180 to 2,983 mL). Autologous red blood cells were transfused to 89.8% (439) of donors but only 0.6% (3) of donors received allogeneic blood. Acute complications related to the collection procedure occurred in 5.9% of donors; but a serious complication, apnea during anesthesia, occurred in only one donor. When donors were questioned approximately 2 days following discharge from their hospitalization, most donors described symptoms related to the collection; 74.8% experienced tiredness, 67.8% experienced pain at the marrow collection site, and 51.6% of the donors experienced low back pain. Donors were surveyed repeatedly until they felt that they had recovered completely. Mean recovery time was 15.8 days; however, 42 (10%) donors felt that it took them > or = 30 days to recover fully. The duration of the marrow collection procedure and duration of anesthesia both positively correlated with donor pain and/or fatigue following the collection; but the duration of the collection procedure had the highest correlation with post-collection pain and fatigue. The volume of marrow collected per unit of donor weight was more weakly correlated with donor pain and/or fatigue than the anesthesia and collection times. When multivariate analysis was used to analyze the correlation between donor recovery time and these variables, only the duration of the collection was found to correlate significantly with donor recovery time (P = .001). This analysis demonstrates that marrow donation is well tolerated with few complications. To decrease further the incidence of donor discomfort and recovery time following donation, the duration of the collection procedure, and probably the duration of anesthesia, and the volume of marrow collected, should be kept to a minimum. 相似文献
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