全文获取类型
收费全文 | 24011篇 |
免费 | 1990篇 |
国内免费 | 44篇 |
专业分类
耳鼻咽喉 | 267篇 |
儿科学 | 847篇 |
妇产科学 | 563篇 |
基础医学 | 3151篇 |
口腔科学 | 554篇 |
临床医学 | 2328篇 |
内科学 | 4404篇 |
皮肤病学 | 562篇 |
神经病学 | 2452篇 |
特种医学 | 683篇 |
外科学 | 3331篇 |
综合类 | 413篇 |
一般理论 | 34篇 |
预防医学 | 2349篇 |
眼科学 | 558篇 |
药学 | 1563篇 |
中国医学 | 20篇 |
肿瘤学 | 1966篇 |
出版年
2022年 | 149篇 |
2021年 | 266篇 |
2020年 | 208篇 |
2019年 | 334篇 |
2018年 | 391篇 |
2017年 | 323篇 |
2016年 | 346篇 |
2015年 | 412篇 |
2014年 | 556篇 |
2013年 | 1040篇 |
2012年 | 1268篇 |
2011年 | 1407篇 |
2010年 | 827篇 |
2009年 | 751篇 |
2008年 | 1384篇 |
2007年 | 1420篇 |
2006年 | 1422篇 |
2005年 | 1403篇 |
2004年 | 1302篇 |
2003年 | 1245篇 |
2002年 | 1192篇 |
2001年 | 396篇 |
2000年 | 347篇 |
1999年 | 397篇 |
1998年 | 329篇 |
1997年 | 266篇 |
1996年 | 236篇 |
1995年 | 226篇 |
1994年 | 231篇 |
1993年 | 235篇 |
1992年 | 304篇 |
1991年 | 307篇 |
1990年 | 314篇 |
1989年 | 278篇 |
1988年 | 238篇 |
1987年 | 196篇 |
1986年 | 253篇 |
1985年 | 214篇 |
1984年 | 234篇 |
1983年 | 213篇 |
1982年 | 256篇 |
1981年 | 226篇 |
1980年 | 185篇 |
1979年 | 191篇 |
1978年 | 139篇 |
1977年 | 148篇 |
1976年 | 144篇 |
1974年 | 160篇 |
1973年 | 135篇 |
1972年 | 137篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
91.
92.
93.
94.
95.
Cerebral hemodynamic and metabolic profiles in fulminant hepatic failure: relationship to outcome. 总被引:2,自引:0,他引:2
Shushma Aggarwal Walter Obrist Howard Yonas David Kramer Yoogoo Kang Victor Scott Raymond Planinsic 《Liver transplantation》2005,11(11):1353-1360
The purpose of this retrospective study was to examine the potential role of cerebral hemodynamic and metabolic factors in the outcome of patients with fulminant hepatic failure (FHF). Based on the literature, a hypothetical model was proposed in which physiologic changes progress sequentially in five phases, as defined by intracranial pressure (ICP) and cerebral blood flow (CBF) measurements. Seventy-six cerebral physiologic profiles were obtained in 26 patients (2 to 5 studies each) within 6 days of FHF diagnosis. ICP was continuously measured by an extradural fiber optic monitor. Global CBF estimates were obtained by xenon clearance techniques. Jugular venous and peripheral artery catheters permitted calculation of cerebral arteriovenous oxygen differences (AVDO2), from which cerebral metabolic rate for oxygen (CMRO2) was derived. A depressed CMRO2 was found in all patients. There was no evidence of cerebral ischemia as indicated by elevated AVDO2s. Instead, over 65% of the patients revealed cerebral hyperemia. Eight of the 26 patients underwent orthotopic liver transplantation-all recovered neurologically, including 6 with elevated ICPs. Of the 18 patients receiving medical treatment only, all 7 with increased ICP died in contrast to 9 survivors whose ICP remained normal (P < 0.004). Hyperemia, per se, was not related to outcome, although it occurred more frequently at the time of ICP elevations. Six patients were studied during brain death. All 6 revealed malignant intracranial hypertension, preceded by hyperemia. In conclusion, the above findings are consistent with the hypothetical model proposed. Prospective longitudinal studies are recommended to determine the precise evolution of the pathophysiologic changes. 相似文献
96.
Lorraine N Clark Eneli Haamer Helen Mejia-Santana Juliette Harris Suzanne Lesage Alexandra Durr Sabine Janin Bs Katja Hedrich Elan D Louis Lucien J Cote Howard Andrews Stanley Fahn Cheryl Waters Blair Ford Steven Frucht William Scott Christine Klein Alexis Brice Hanno Roomere Ruth Ottman Karen Marder 《Movement disorders》2007,22(7):932-937
Parkin mutations account for the majority of familial and sporadic early onset Parkinson's disease (EOPD) cases with a known genetic association. More than 100 mutations have been described in the Parkin gene that includes homozygous, compound heterozygous, and single heterozygous mutations. We have designed a Parkin mutation genotyping array (gene chip) that includes published Parkin sequence variants and allows their simultaneous detection. The chip was validated by screening 85 PD cases and 47 controls previously tested for Parkin mutations. Similar genotyping microarrays have been developed for other genetically heterogeneous diseases including age-related macular degeneration. Here, we show the utility of a genotyping array for Parkinson's disease by analysis of 60 subjects from the Genetic Epidemiology of Parkinson Disease (GEPD) study that includes 15 early-onset PD case probands and 45 relatives. 相似文献
97.
98.
99.
100.
Howard B Moss Thomas L Hardie John P Dahl Wade Berrettini Ke Xu 《Neuropsychopharmacology》2007,61(8):974-978
BACKGROUND: Some studies have associated alcohol dependence (AD) with the human serotonin (5-HT)(1B) receptor (HTR1B). This investigation explored the functional responsivity of HTR1B in abstinent AD men using a sumatriptan challenge, while measuring genetic heterogeneity in the HTR1B promoter. METHODS: Abstinent AD men (n = 27) and abstinent men without any alcohol use disorder (n = 19) were administered 6 mg of sumatriptan succinate, subcutaneously. Plasma samples collected over the following 2 hours were assayed for growth hormone (GH) concentrations. His DNA was genotyped for the A-161T and T-261G polymorphisms of the HTR1B promoter and diplotypes determined. RESULTS: Integrated GH responses were predicted by interactions of AD and promoter diplotypes, as well as subject ethnicity. The final model accounted for nearly 35% of the variance in GH responses. Post hoc evaluation revealed that AD was associated with a blunting of GH secretion only among individuals with the most common HTR1B diplotype (TT/TT). CONCLUSIONS: A blunting of GH responses in abstinent AD men was observed only among those with the most common HTR1B promoter diplotype. Less common promoter diplotypes appeared protective. Controlling for genetic background is a useful augmentation of case-control pharmacological challenge strategies designed to elucidate the psychobiology of AD and other complex disorders. 相似文献