寻常痤疮发病机制相关信号通路的研究进展

寻常痤疮是一种毛囊皮脂腺单位的炎症疾病,在青少年中的发病率高达85%,发病机制与雄激素、皮脂分泌、嗜脂性微生物感染、免疫-炎症反应等密切相关。本文从炎症信号通路、皮脂分泌通路方面,综述与痤疮相关的信号转导通路。     

O2O互动型教学模式在住院医师规范化培训中的应用

目的探讨线上线下（online to offline，O2O）互动型教学模式在住院医师规范化培训中的应用效果。方法以首都医科大学宣武医院医师规范化培训的36名学生作为试验组，每组成员6〖FGS〗~〖FGN〗8人，另外36名前期住院医师作为对照组，试验组采用O2O互动教学法，对照组按照传统教学模式。教学完成后比较两组理论和临床实践技能成绩以及问卷调查结果。结果试验组理论和临床实践技能成绩均优于对照组（P<0.05）,且各项效果评价也优于对照组（P<0.05）。结论O2O互动型教学模式能够为住院医师规范化培训教学提供更优化的教学。     

完全内脏反位合并先天性食管闭锁手术新生儿的护理

对1例完全内脏反位合并先天性食管闭锁新生儿行手术治疗,患儿术后恢复良好,未出现并发症。提出做好围手术期呼吸道、胃管及胸腔引流管和疼痛护理是新生儿手术成功的关键。     

间苯三酚联合缩宫素对需引产分娩的初产妇产程进展和分娩结局的影响

目的 探讨间苯三酚联合缩宫素应用对于需引产分娩的初产妇产程进展、产妇及新生儿分娩结局的影响.方法 选取2019年1月至2020年12月在合肥市第三人民医院需引产分娩的足月单胎初产妇60例,采用随机数字表法分为观察组与对照组,每组30例,对照组单用缩宫素治疗,观察组应用缩宫素联合间苯三酚治疗,收集产妇的产程进展、产后出血量、宫颈或阴道裂伤发生率、产时羊水Ⅲ度发生率、阴道分娩率和新生儿Apgar评分等,并对两组数据进行比较.结果 观察组第一产程、总产程时间分别为(407.9±125.4)min、(450.5±131.0)min,均显著短于对照组的(663.3±218.2)min、(722.1±223.4)min(P<0.05).两组阴道分娩率、产后出血量、宫颈或阴道裂伤发生率、产时羊水Ⅲ度发生率的差异无统计学意义(P>0.05).结论 间苯三酚联合缩宫素静滴,可缩短产程,且不影响母婴安全.     

Estimating genome conservation between crop and model legume species

Legumes are simultaneously one of the largest families of crop plants and a cornerstone in the biological nitrogen cycle. We combined molecular and phylogenetic analyses to evaluate genome conservation both within and between the two major clades of crop legumes. Genetic mapping of orthologous genes identifies broad conservation of genome macrostructure, especially within the galegoid legumes, while also highlighting inferred chromosomal rearrangements that may underlie the variation in chromosome number between these species. As a complement to comparative genetic mapping, we compared sequenced regions of the model legume Medicago truncatula with those of the diploid Lotus japonicus and the polyploid Glycine max. High conservation was observed between the genomes of M. truncatula and L. japonicus, whereas lower levels of conservation were evident between M. truncatula and G. max. In all cases, conserved genome microstructure was punctuated by significant structural divergence, including frequent insertion/deletion of individual genes or groups of genes and lineage-specific expansion/contraction of gene families. These results suggest that comparative mapping may have considerable utility for basic and applied research in the legumes, although its predictive value is likely to be tempered by phylogenetic distance and genome duplication.     

正压无针连接式留置针在儿科的应用研究

目的探讨24G新型正压无针连接式留置针在儿科神经内科静脉输液治疗中的应用效果。方法选择2015年7月至2015年8月期间本科住院患儿120例,按照随机数字表法将其分为对照组与观察组,统计静脉滴注过程中的滴注速度,留置时间,留置效果,并发症发生率,头皮针更换率及针刺伤发生率等情况。结果观察组采用24G新型正压无针连接式留置针留置效果与对照组采用普通留置针相比,血管损伤少,红、肿、堵管等并发症发生率低,针刺伤发生率低,更换头皮针的次数少,工作效率高,以上所有差异均具有统计学意义,P0.05。结论 24G新型正压无针连接式留置针导管采用新型防堵管材质,减少了血液有形成分,保证了液体的输注速度,减少了堵管的发生,延长了留置时间,还能避免针刺伤,保护医护人员及患者,降低职业风险,减少了护士更换头皮针的次数,减轻了护士工作量。     

The application of the Chinese version of the Body Image Disturbance Questionnaire in patients with systemic lupus erythematosus

This study aimed to translate the Body Image Disturbance Questionnaire (BIDQ) into Chinese and evaluate its reliability and validity in a sample of patients with systemic lupus erythematosus (SLE).Following the translation and revision of the Chinese version of the BIDQ, 169 patients with SLE were chosen as respondents to test the questionnaire''s reliability and validity. We tested the content''s validity through expert group evaluation. It is structural validity was examined through exploratory factor analysis and confirmatory factor analysis, and reliability was evaluated using Cronbach''s α and test-retest reliability.The Chinese version of the BIDQ showed a content validity of .92. A two-factor structure was revealed by exploratory factor analysis, which explained 67.83% of the variance and proved by confirmatory factor analysis. Its overall Cronbach''s α was .82 (P < .001), and the Cronbach''s α for each item ranged from .76 to .83. The test-retest reliability was .82, with the Cronbach''s α for each item ranging from .76 to .84.Thus, adequate reliability and validity of the Chinese version of the BIDQ were demonstrated for use in patients with SLE.