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131.
Effects of testosterone enanthate and resistance training on myocardium in Wistar rats; clinical and anatomical pathology
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This study was performed to determine the effects of 8 weeks testosterone enanthate (TE) injection and resistance training (RT) on cardiac muscle in male Wistar rats. A total of 28 male adult Wistar rats were randomly divided into 4 groups; control + placebo, RT + placebo, TE and TE + RT. Testosterone enanthate (20 mg/kg BW, IM) and placebo (olive oil; 0.2 ml, IM) were injected twice a week for 2 months. The RT consisted of climbing (5 reps/3 sets) a ladder carrying a load suspended from the tail. The serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and creatine kinase MB (CK‐MB) and serum level of creatinine, urea and cardiac troponin I (CTnI) were evaluated. After sacrifice, samples from myocardial muscle were collected for histopathology evaluation. The serum concentration of CTnI and CK‐MB activity significantly increased in group RT compared with control (p < .05). In group RT + TE, all biomarkers of muscle damage (CTnI, CK‐MB, AST, LDH) were significantly more than those in control (p < .05). Also, mild myocardial hypertrophy was observed in RT and RT + TE groups. The higher level of all heart damage biomarkers in the RT + TE group rather than control may indicate the synergistic effects of medication and exercise. 相似文献
132.
Breast Necrosis Secondary to Vasopressor Extravasation: Management Using Indocyanine Green Angiography and Omental Flap Closure
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Thomas M. Hagopian MD Paul A. Ghareeb MD Brian H. Arslanian MD Benjamin L. Moosavi MD Grant W. Carlson MD 《The breast journal》2015,21(2):185-188
Extravasation is a rare but serious complication of vasopressor administration. A 60‐year‐old female who underwent ascending and hemiarch repair of the aorta along with aortic valve replacement developed extensive right breast and chest wall necrosis after vasopressor extravasation from an internal jugular vein central line. The patient underwent a total mastectomy due to deep tissue necrosis detected by laser‐assisted indocyanine green dye angiography, and eventually required omental flap reconstruction to obtain adequate sternal coverage. This case represents a previously unreported complication of internal jugular central line extravasation of vasopressors with resultant breast and chest wall necrosis, and highlights the utility of the omentum in chest wall reconstruction. 相似文献
133.
134.
Hengameh Bakhtiar Mohammad Hossein Nekoofar Pouyan Aminishakib Fatemeh Abedi Fereshteh Naghi Moosavi Ehsan Esnaashari Arash Azizi Samar Esmailian Mohammad Reza Ellini Vahid Mesgarzadeh Mehdi Sezavar Imad About 《Journal of endodontics》2017,43(11):1786-1791
Introduction
Questions exist regarding the efficacy of resin-containing materials such as TheraCal directly applied on the pulp. This study sought to investigate the clinical efficacy of TheraCal as compared with Biodentine and ProRoot mineral trioxide aggregate (MTA) for partial pulpotomy.Methods
In this clinical trial, partial pulpotomy was performed for 27 sound human maxillary and mandibular third molars scheduled for extraction. The teeth were randomly divided into 3 groups (n = 9) and underwent partial pulpotomy with TheraCal, Biodentine, and ProRoot MTA. The teeth were then restored with glass ionomer cement. Clinical and electric pulp tests were performed after 1 and 8 weeks. The teeth were radiographed and extracted at 8 weeks. Histologic sections were prepared and analyzed for pulp inflammation and dentinal bridge formation. Data were analyzed by using one-way analysis of variance.Results
Clinical examination showed no sensitivity to heat, cold, or palpation in ProRoot MTA and Biodentine groups. Two patients in TheraCal group (20%) reported significant pain at 1 week. Periapical radiographs showed no periapical pathology, and electric pulp test revealed a normal pulp response with no hypersensitivity. Inflammation was absent with all materials at 8 weeks. Normal pulp organization was seen in 33.33% of the teeth in ProRoot MTA, 11.11% in TheraCal, and 66.67% in Biodentine group (P = .06). Biodentine group showed complete dentinal bridge formation in all teeth, whereas this rate was 11% and 56% in TheraCal and ProRoot MTA groups, respectively (P = .001).Conclusions
Overall, Biodentine and MTA performed better than TheraCal when used as partial pulpotomy agent and presented the best clinical outcomes. 相似文献135.
Alimohammad Fatemi Mahdi Moosavi Zahra Sayedbonakdar Ziba Farajzadegan Mehdi Kazemi Abbas Smiley 《Clinical rheumatology》2014,33(9):1273-1278
We aimed to evaluate the therapeutic effects of atorvastatin on systemic lupus erythematosus disease activity index (SLEDAI). Ninety patients with SLE were consented and randomized to receive either atorvastatin, 20 mg/day, or placebo for 3 months. The primary outcome was change in SLEDAI. Lipids, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were assessed as secondary end points. Analysis was done by “intention to treat” (ITT) as the primary analysis and “treatment completed analysis” (TCA) as the supplementary analysis. Demographic features, baseline characteristics, and distribution of medications were not significantly different between the two groups. Mean SLEDAI score at baseline in both groups was 3?±?0.5. By TCA and ITT, mean SLEDAI scores decreased to 1.7?±?0.4 and 2.7?±?0.5, respectively, in the atorvastatin group and 3?±?0.4 and 3?±?0.5, respectively, in the control group. The difference between the two groups after intervention was significant by TCA (P?0.05) and nonsignificant by ITT analysis (P?=?0.1). The effect of atorvastatin therapy on lupus activity was inconclusive. 相似文献
136.
Molecular dynamics simulations of neutral gold nanoparticles (AuNPs) interacting with dipalmitoylphosphatidylcholine (DPPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membranes were studied using a model system. Spontaneous membrane insertion of AuNPs did not occur on the time scale of atomistic simulations. To overcome the limitations of time scale, we used a harmonic restraining potential to force the AuNPs into the membranes. Free energy calculations indicate that a NP has to cross a free energy barrier of about 134 kJ mol−1 prior to forming a stable contact with the membrane. This energy barrier between lipids and NPs comes from the repulsion between headgroups of lipids and AuNPs. The experimental investigations indicate that, contrary to hydrophobic AuNPs, neutral AuNPs cannot form ion channels across lipid membranes. The adsorption of NPs induces the formation of a highly ordered region in phospholipid bilayers. Our simulation results propose that the cell penetration of small uncoated AuNPs does not involve energy-independent membrane translocation but rather involves the energy-dependent formation of nanoscale membrane holes or energy-dependent endocytosis.Molecular dynamics simulations of neutral gold nanoparticles (AuNPs) interacting with dipalmitoylphosphatidylcholine (DPPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membranes were studied using a model system. 相似文献
137.
Pham MX Whooley MA Evans GT Liu C Emadi H Tong W Murphy MC Fleischmann KE 《American heart journal》2004,148(5):776-782
Background
Low-level cardiac troponin-I (cTn-I) elevations predict adverse cardiovascular outcomes in patients with definite acute coronary syndromes (ACS), as defined by the presence of chest pain accompanied by ischemic electrocardiographic changes. However, their prognostic value in other clinical situations remains unclear.Methods
We studied 366 patients with suspected myocardial infarction (MI) but without definite ACS, including 57 patients with low-level cTn-I elevations (1.0 to 3.0 ng/mL) and 309 patients with cTn-I <1.0 ng/mL. All cTn-I measurements were made with the Dade Stratus II analyzer. We determined the adjusted 1-year risk of nonfatal MI or death from coronary heart disease (CHD death) in each group by using Cox proportional hazards models.Results
Among patients with cTn-I elevations between 1.0 and 3.0 ng/mL, 6 (11%) had a nonfatal MI or CHD death at 1 year compared with 12 (4%) patients in the cTn-I <1.0 ng/mL group [hazard ratio (HR), 3.5; 95% CI, 1.4 to 8.8]. After adjusting for baseline clinical characteristics, cTn-I levels between 1.0 and 3.0 ng/mL remained strongly associated with nonfatal MI or CHD death (adjusted HR, 3.4; 95% CI, 1.3 to 9.4). This association persisted even in the 215 patients who presented without chest pain (adjusted HR, 4.3; 95% CI, 1.4 to 13).Conclusions
Low-level cTn-I elevations identify a subset of patients at increased risk for future cardiovascular events, even when obtained outside the context of definite ACS or presentation with chest pain. 相似文献138.
S. Mostafa Shid Moosavi Saeed C. Ashtiyani Saman Hosseinkhani Mehdi Shirazi 《Urological research》2010,38(3):187-194
The suppression of renal energy metabolism during ureteral obstruction is a well-known phenomenon; however, its exact responsible
mechanism(s) and association with simultaneously induced renal oxidative stress have not been clarified. This study examined
the improving effects of l-carnitine, a facilitating cofactor for mitochondrial oxidation of fatty-acids as well as a scavenger of free-radicals, and
α-tocopherol as the most potent antioxidant on renal metabolic defect and oxidative stress induced by acute unilateral ureteral
obstruction (UUO). The left ureter was ligated in ether-anaesthetised rats, in which l-carnitine, α-tocopherol or their vehicles were intraperitoneally injected in four different groups. After elapsing 24 h of
UUO-induction, both kidneys were removed and stored at −80°C. There were also two sham-operated and control groups. The kidney
samples were assessed to measure the levels of ferric reducing/antioxidant power (FRAP) and malondialdehyde (MDA) for evaluating
their redox state, as well as, their amounts of adenosine triphosphate (ATP) and adenosine diphosphate (ADP) by using luciferin–luciferase
method. As much as 24 h of UUO in vehicle-treated groups caused increases in MDA and ADP, but decreases in FRAP, ATP, and
ATP/ADP of the obstructed kidney with respect to those of the sham group. α-tocopherol normalised the levels of MDA and FRAP
but did not affect the altered amounts of energy metabolic indices in the obstructed kidney, while l-carnitine could ameliorate all of them. These findings suggest that oxidative stress may not involve in development of acute
UUO-induced suppression of renal aerobic metabolism, and probably reduction of energy substrates is a responsible factor. 相似文献
139.
140.
Afsaneh Doosti Yones Lotfi Abdollah Moosavi Enayatollah Bakhshi Azita Hajhossein Talasaz 《Indian journal of otolaryngology and head and neck surgery》2014,66(3):325-329
Distortion product otoacoustic emission (DPOAE) appears to be an objective sensitive test of cochlear function. The aim of this study was to investigate whether DPOAE is an appropriate tool for assessment of minute changes in cochlea due to usage of antioxidant material. 48 workers exposed to continuous noise in a textile factory were randomly assigned into three groups: (1) The Control group (n = 16) received no antioxidant drugs, (2) The N-acetyl-cysteine (NAC) group (n = 16) received oral antioxidant NAC (1200 mg/day), (3) The Ginseng group (n = 16) received oral antioxidant Ginseng (200 mg/day). All three groups had a follow-up period of 2 weeks. The cochlear changes were assessed using DPOAE test before starting the daily work shift on first and 15th day. The associations between groups and DPOAE amplitudes after 2 weeks were analyzed using linear regression analysis. Four separate models were fitted by side of ears and frequency. All models were adjusted for baseline amplitude. Reduced (better) amplitude at DPOAE test was found for NAC and Ginseng groups at high frequencies (4 and 6 kHz) in both ears after 2 weeks compared to control group. Moreover, NAC group showed better DPOAE amplitude than Ginseng group. In conclusion, DPOAE seems to be an appropriate tool in assessing minute changes in the cochlea after antioxidant drugs administration. 相似文献