全文获取类型
收费全文 | 391篇 |
免费 | 21篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 13篇 |
妇产科学 | 12篇 |
基础医学 | 63篇 |
口腔科学 | 1篇 |
临床医学 | 34篇 |
内科学 | 57篇 |
皮肤病学 | 9篇 |
神经病学 | 30篇 |
特种医学 | 44篇 |
外国民族医学 | 1篇 |
外科学 | 46篇 |
综合类 | 7篇 |
预防医学 | 39篇 |
眼科学 | 3篇 |
药学 | 27篇 |
中国医学 | 5篇 |
肿瘤学 | 21篇 |
出版年
2023年 | 6篇 |
2022年 | 8篇 |
2021年 | 28篇 |
2020年 | 16篇 |
2019年 | 20篇 |
2018年 | 34篇 |
2017年 | 26篇 |
2016年 | 12篇 |
2015年 | 14篇 |
2014年 | 22篇 |
2013年 | 27篇 |
2012年 | 40篇 |
2011年 | 43篇 |
2010年 | 16篇 |
2009年 | 15篇 |
2008年 | 18篇 |
2007年 | 20篇 |
2006年 | 13篇 |
2005年 | 10篇 |
2004年 | 6篇 |
2003年 | 5篇 |
2002年 | 1篇 |
2001年 | 4篇 |
2000年 | 2篇 |
1999年 | 2篇 |
1996年 | 1篇 |
1993年 | 1篇 |
1990年 | 3篇 |
1989年 | 1篇 |
1986年 | 1篇 |
排序方式: 共有415条查询结果,搜索用时 507 毫秒
21.
Sajid Mahmood Tahira Perveen Allah Dino Faisa Ibrahim Jaishri Mehraj 《Indian Journal of Community Medicine》2014,39(2):87-93
Objectives:
To assess the effectiveness of school-based interventions program in reducing the prevalence of overweight or obesity among schoolchildren.Data source:
Ovid Medline (1950-December 2012), Embase (1980-2012), CINAHL (1982-2012), secondary references, review articles, and expert in the field.Study selection:
All published clinical trials were eligible for study if were randomized, methodologically strong-based on a validity assessment, aimed to evaluate a school-based intervention for childhood overweight or obesity, and measured outcome in term of prevalence/incidence difference in overweight and obesity among both groups. Studies involved in cost-effective analysis of school-based intervention have been excluded. Data from eligible studies abstracted and pooled for relative risk.Results:
Five trials with 3,904 schoolchildren were included. Mean age of the students (boys and girls) ranges 8.6-12.6 years. Meta-analysis showed a statistical significance beneficial effect of school-based intervention programs on obesity status of schoolchildren (risk ratio (RR) 0.58, 95% confidence interval (CI) 0.43-0.78) and suggested 42% reduction in prevalence of obesity among schoolchildren through school-based intervention programs. Individual studies also showed effectiveness of these school-based interventions.Conclusion:
School-based intervention programs are effective in prevention of childhood overweight and obesity problem and our results quantitatively supported this argument. 相似文献22.
The neuropeptide substance P (SP) triggers a variety of tumor-promoting signaling pathways through the activation of neurokinin-1receptor (NK1R), a class of neurokinin G protein-coupled receptors superfamily. Recent researches in our and other laboratories have shown the overexpression of both SP and NK1R in breast cancer (BC) patients. SP/NK1R signaling is strongly implicated in the pathogenesis of BC through affecting cell proliferation, migration, metastasis, angiogenesis, and resistance. Therefore, SP/NK1R signaling responses must be rigorously regulated; otherwise, they would contribute to a more aggressive BC phenotype. Recently, microRNAs (miRNAs) as a specific class of epigenetic regulators have been shown to regulate NK1R and thus, controlling SP/NK1R signaling responses in BC. This review summarizes the current knowledge of the role of SP/NK1R signaling and its therapeutic potentials in BC. We also provide an overview regarding the effects of miRNA-mediated NK1R regulatory mechanisms in controlling BC tumorigenesis to gain a clearer view and thus better management of cancer. 相似文献
23.
24.
Dadgar Habibollah Emami Farshad Norouzbeigi Nasim Vafaee Manouchehr Seyedi Jafari Esmail Gholamrezanezhad Ali Assadi Majid Ahmadzadehfar Hojjat 《Molecular imaging and biology》2020,22(4):1062-1069
Molecular Imaging and Biology - The early and accurate diagnosis of locoregional recurrence or metastasis in prostate cancer (PC) has a significant impact on treatment options. Prostatic-specific... 相似文献
25.
Maha Hasab Allah Zakaria A. Salama Aly El-Hindawy Nabil Al Kady 《Arab Journal Of Gastroenterology》2012,13(3):116-124
Background and study aimsAscites may be of undetermined origin despite comprehensive study. This study aimed to assess the accuracy and safety of conventional and interventional high-frequency peritoneal ultrasound in the diagnosis of patients with ascites of unclear origin.Patients and methodsA total of 62 patients were prospectively enrolled; they underwent conventional (3.5–5 MHz) and high-frequency (6–8 MHz) transabdominal peritoneal ultrasound to suggest the nature of ascites supplemented by fine needle aspiration cytology (FNAC) of ascites and/or core biopsy of the omentum or other extra-visceral masses for final histopathologic diagnosis. Laparoscopy or laparotomy was needed if biopsy was inconclusive.ResultsUltrasound-guided procedures were diagnostic in 55 (87.7%) patients. Thirty-six (58.1%) were benign, of whom 86% had tuberculous peritonitis, 26 (41.9%) were malignant, of whom 76.9% had peritoneal metastasis. High-frequency ultrasound was able to propose ultrasonographic criteria in a trial to diagnose the nature of ascites. Our proposed ultrasonographic criteria were based on the amount and texture of ascites in addition to the omental and mesenteric features. These were able to suggest the diagnosis with 80.7% sensitivity for malignant ascites and 75% specificity for benign ascites. Moreover, histopathological examination of tissues obtained by ultrasound-guided procedures increased the sensitivity to 88.5% and the specificity to 88.9% in diagnosing malignant and benign disease, respectively, with an overall diagnostic accuracy of 88.6%. These procedures were considered to be safe as only one major (haemoperitoneum) and two minor complications (temporary ascitic fistula) were reported.ConclusionHigh-frequency peritoneal ultrasound together with the minimally invasive ultrasound-guided FNAC/biopsy of extra-visceral lesions may be considered an effective and safe tool in the diagnosis of ascites of undetermined origin. 相似文献
26.
Prevalence of acne vulgaris and its impact of the quality of life among secondary school‐aged adolescents in Sohag Province,Upper Egypt
下载免费PDF全文
![点击此处可从《Journal of Cosmetic Dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
27.
Noha H. Ibrahim Mona S. Abdellateif Samar Hassab‐Allah Kassem Mohamed Ahmed Abd El Salam Mosaad M. El Gammal 《Andrologia》2019,51(10)
Prostate cancer (PC) is considered as the fifth cause of cancer deaths worldwide. The exact etiopathogenesis is unclear; however, genetic predisposition, hormonal influencers, lifestyle and environmental factors act as major contributors. It has been found that several miRNAs may play a crucial role in cancer initiation and progression. Here, in this study, we evaluated the peripheral blood levels of miR‐21, miR‐141, miR‐221 and miR‐18a expression among 80 prostate cancer patients (50 localised and 30 metastatic) and 30 benign prostatic hyperplasia patients compared to 50 normal control subjects, using RT‐PCR. Our results of analysis of miR‐21, miR‐141, miR‐18a and miR‐221 in the plasma of PC patients showed that miR‐18a is a powerful discriminator of PC patients from healthy controls as it had the highest AUC (0.966; 95% CI, 0.937–1.000), while miR‐221 provided better differentiation of metastatic from localised PC (sensitivity was 92.9% at 100% specificity), and when we combine miR‐18a and miR‐221 for differentiating patients with MPC, it will increase the sensitivity to 96.4% at a specificity of 100% (AUC, 0.997; 95% CI, 0.988–1.0) (p < .000). This current study recommends that analysis of these miRNAs might have clinical value in enhancing PSA testing. 相似文献
28.
29.
30.
Most drugs of abuse increase dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) release in the shell of the nucleus accumbens. The effects of ascorbate, which is known to modulate dopamine neurotransmission, on the extracellular level of DOPAC in the nucleus accumbens of naive rats and of rats treated acutely with morphine were studied by using in vivo microdialysis and high performance liquid chromatography with electrochemical detection (HPLC-ECD). Acute morphine (20 mg/kg ip) treatment increased the level of DOPAC in the nucleus accumbens to approximately 170% of basal level. Acute treatment with ascorbate (500 mg/kg ip) alone did not alter nucleus accumbens' DOPAC level, but pretreatment with ascorbate (500 mg/kg ip) 30 min before morphine administration attenuated the effects of acute morphine on the level of DOPAC. These results suggest that ascorbate modulates the mesolimbic dopaminergic pathway. 相似文献