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31.
Kumchoo K Wongsawad C Chai JY Vanittanakom P Rojanapaibul A 《The Southeast Asian journal of tropical medicine and public health》2005,36(2):451-455
This study aimed to investigate Haplorchis taichui metacercarial infection in fish collected from the Chom Thong and Mae Taeng districts, Chiang Mai Province during November 2001 to October 2002. A total 617 cyprinoid fish of 15 species were randomly collected and examined for H. taichui metacercariae. All the species of fish were found to be infected with H. taichui. The infection rates were 91.4% (266/290) and 83.8% (274/327), with mean intensities of 242.9 and 107.4 in the Chom Thong and Mae Taeng districts, respectively. The portion of the fish body with the highest metacercarial density was the muscles, and second, the head, in both districts. In addition, the fish had mixed-infection with other species of trematodes, namely: Centrocestus caninus, Haplorchoides sp, and Haplorchis pumilio. 相似文献
32.
Mahakunakorn P Tohda M Murakami Y Matsumoto K Watanabe H 《Biological & pharmaceutical bulletin》2004,27(1):38-46
The antioxidant properties of Choto-san and its related constituents such as Chotoko and Choto-san without Chotoko, and phenolic compounds contained in Chotoko such as epicatechin, caffeic, acid and quercetin were evaluated. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, the scavenging activity of Chotoko (IC(50) 14.3 microg/ml) was found to be higher than that of Choto-san (IC(50) 206.2 microg/ml) and Choto-san without Chotoko (IC(50) 244.3 microg/ml). Epicatechin (IC(50) 10.4 microM), caffeic acid (IC(50) 13.8 microM), and quercetin (IC(50) 7.1 microM) also revealed scavenging activity against DPPH radicals. Choto-san (IC(50) 67.7 microg/ml) exhibited stronger inhibitory activity against superoxide anion formation than Choto-san without Chotoko (IC(50) 92.4 microg/ml) but weaker activity than Chotoko (IC(50) 18.3 microg/ml). The generation of superoxide anion was also inhibited by epicatechin (IC(50) 175.2 microM), caffeic acid (IC(50) 141.7 microM), and quercetin (IC(50) 18.7 microM). In a hydroxyl radical-scavenging experiment, Choto-san (IC(50) 2.4 mg/ml), Chotoko (IC(50) 2.2 mg/ml), Choto-san without Chotoko (IC(50) 2.8 mg/ml), epicatechin (IC(50) 3.9 mM), caffeic acid (IC(50) 3.6 mM), and quercetin (IC(50) 1.9 mM) exhibited activity. In NG108-15 cells, when added simultaneously with H(2)O(2) (500 microM), Choto-san (250 microg/ml), Chotoko (250 microg/ml), Choto-san without Chotoko (500 microg/ml), epicatechin (200 microM), caffeic acid (200 microM), and quercetin (200 microM) effectively protected cells from oxidative damage. In conclusion, the present results provide evidence that Choto-san acts as an antioxidant and cytoprotective agent against oxidative damage, which is due at least partly to the phenolic compounds contained in Chotoko. 相似文献
33.
Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria
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Newton PN van Vugt M Teja-Isavadharm P Siriyanonda D Rasameesoroj M Teerapong P Ruangveerayuth R Slight T Nosten F Suputtamongkol Y Looareesuwan S White NJ 《Antimicrobial agents and chemotherapy》2002,46(4):1125-1127
Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated falciparum malaria. The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate. 相似文献
34.
Cytoprotective and cytotoxic effects of curcumin: dual action on H2O2-induced oxidative cell damage in NG108-15 cells 总被引:3,自引:0,他引:3
Mahakunakorn P Tohda M Murakami Y Matsumoto K Watanabe H Vajaragupta O 《Biological & pharmaceutical bulletin》2003,26(5):725-728
The ability of curcumin, a natural antioxidant isolated from Curcuma longa, to inhibit hydrogen peroxide (H(2)O(2))-induced cell damage in NG108-15 cells was examined. When added simultaneously with 500 microM H(2)O(2), curcumin (25-100 microM) effectively protected cells from oxidative damage. However, when the cells were pretreated with curcumin (25-100 microM) for 1.5 h before H(2)O(2) exposure, curcumin was unable to inhibit H(2)O(2)-induced cell damage. Instead, it caused a significant concentration-dependent decrease in cell viability after H(2)O(2) exposure. This dual action of curcumin suggests that pretreatment with curcumin by itself did not have any significant effect on the viability of the NG108-15 cells, but it sensitized them to oxidative damage induced by H(2)O(2) under our experimental conditions. It appears that these events may not relate to the antioxidant and free radical scavenging activities of curcumin. 相似文献
35.
Hochareon P Manning KB Fontaine AA Tarbell JM Deutsch S 《ASAIO journal (American Society for Artificial Internal Organs : 1992)》2004,50(6):537-542
Flow stasis in an artificial heart may provide a situation where thrombus develops. Should part, or all, of the clot dislodge, a thromboembolism may lead to stroke(s), neurologic deficits, or even death. In an effort to determine if the regime of low shear or stasis exists, a two-dimensional particle image velocimetry (PIV) system was implemented to measure the velocity field within the 50 cc Penn State Artificial Heart. The velocity measurements were decomposed nearest the wall to obtain wall shear rates along the bottom of the chamber. The PIV measurements were made in three image planes across the depth of the chamber to reconstruct a surface distribution of the wall shear rates at the bottom over the entire heart cycle. The wall shear rate is shown to be spatially nonuniform, with persistently low wall shear rates. An area near the front edge of the chamber at the bottom showed wall shear rates not exceeding 250 s(-1). This was an area of clot formation seen in vivo, suggesting a link may exist between the low wall shear rate zone and thrombus formation. 相似文献
36.
Haque QM Yoshimura H Midorikawa Y Nakamura S Sugiyama A Iwade Y Thongkrajai P Kuyyakanond T Mairiang P Pienthaweechai K Yamauchi T 《Environmental health and preventive medicine》1996,1(1):20-27
An epidemiological and bacteriological study of diarrheal diseases as well as the relation between domestic-use water and passage of enteric pathogens with stools of the villagers was performed in the northeastern rural area of Thailand on 4 different occasions during the 3 years from 1992-1994. The questionnaire study indicated that 93% of the residents used rain water stored in containers for drinking and other domestic uses, and that 28% of them filtrated and/or boiled the water before drinking it. About 90% of drinking water samples collected from the same residents showed positive responses for the preliminary test ofEscherichia coli contamination. Furthermore, a precise bacteriological survey indicated that more than half of the drinking water samples collected from containers storing rain water were contaminated with various enteropathogenic bacteria, includingE. coli, Vibrio spp. andShigella spp. The new serotype ofV. cholerae O139, synonym 'Bengal cholerae,' which could be isolated from different specimens, is replacing the traditional species ofVibrio. Forty-one per cent of the villagers carried enteropathogenic bacteria in their stools. Most of them were asymptomatic carriers and only a few of them showed clinical features of diarrhea. A few concrete propositions were discussed to supply safe water in these areas where drinkable underground water is not available. 相似文献
37.
Hill K Vapattanawong P Prasartkul P Porapakkham Y Lim SS Lopez AD 《International journal of epidemiology》2007,36(2):374-384
BACKGROUND: In the late 1980s and early 1990s a generalized HIV epidemic affected Thailand which was relatively well controlled by an intensive national campaign by the mid 1990s. The extent to which the epidemic has slowed or possibly reversed the epidemiological transition in Thailand is relatively unknown. METHODS: Under-five mortality rates (U5MR) were determined from various sources and weighted least squares regression conducted to determine U5MR over the years 1980-2000. Direct and indirect estimates of the completeness of death registration were used to estimate mortality levels in those aged more than 5 years for the 1980-90 and 1990-2000 periods. Life tables were constructed using the various estimates to determine changes in life-expectancy between the two time periods. RESULTS: U5MR in Thailand is estimated to have been 58/1000 live births in 1980, declining to 30 in 1990 and to 23 in 2000. The vital registration system clearly underestimates U5MR. Successive surveys of Population Change (SPC) imply coverage of death registration improving from 75-77% in 1985-86 to 95% in 1995-96, partly due to a reliance on self-reported registration in the latter survey. In contrast, the General Growth Balance-Synthetic Extinction Generations (GGB-SEG) method suggests coverage worsening from 78-85% in 1980-90 to 64-72% in 1990-2000. Life tables based on SPC adjustments show continued declines in female, and to a lesser extent, male adult mortality with corresponding increases in life-expectancy at birth of around 6 years for both sexes from 1980-90 to 1990-2000. In contrast, the indirect adjustments suggest a substantial increase in male adult mortality with female adult mortality unchanged; life expectancy decreased by 4 years for males and was only marginally higher in females. CONCLUSION: Given the conflicting evidence a definitive assessment of mortality change in Thailand between 1980 and 2000 is difficult to make. Indirect adjustments, based on demographic methods point to a major reversal in mortality decline among males, and a slowing in females. If adult mortality registration has declined, and given the continued under-registration of infant and child deaths, remedial measures are urgently required if the mortality system is to better inform and monitor health development in Thailand. 相似文献
38.
A male neonate with seizures, linear sebaceous nevus syndrome and hemimegalencephaly underwent hemispherectomy at 36 weeks' gestational age. He has had no clinical seizures in the 13 months since surgery but continues to have sharp wave activity over some parts of the intact hemisphere. He has moderate developmental delay and a mild hemiparesis but is making developmental progress. 相似文献
39.
Patama Vapattanawong Wichai Aekplakorn Uthaithip Rakchanyaban Pramote Prasartkul Yawarat Porapakkham 《BMC public health》2010,10(1):604
Background
To assess the association of body mass index with mortality in a population-based setting of older people in Thailand. 相似文献40.