全文获取类型
收费全文 | 2030篇 |
免费 | 176篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 30篇 |
妇产科学 | 24篇 |
基础医学 | 331篇 |
口腔科学 | 22篇 |
临床医学 | 255篇 |
内科学 | 465篇 |
皮肤病学 | 61篇 |
神经病学 | 81篇 |
特种医学 | 88篇 |
外科学 | 239篇 |
综合类 | 22篇 |
一般理论 | 1篇 |
预防医学 | 209篇 |
眼科学 | 82篇 |
药学 | 171篇 |
中国医学 | 6篇 |
肿瘤学 | 129篇 |
出版年
2023年 | 24篇 |
2022年 | 78篇 |
2021年 | 145篇 |
2020年 | 51篇 |
2019年 | 86篇 |
2018年 | 80篇 |
2017年 | 41篇 |
2016年 | 60篇 |
2015年 | 63篇 |
2014年 | 98篇 |
2013年 | 101篇 |
2012年 | 152篇 |
2011年 | 133篇 |
2010年 | 68篇 |
2009年 | 68篇 |
2008年 | 110篇 |
2007年 | 113篇 |
2006年 | 94篇 |
2005年 | 89篇 |
2004年 | 86篇 |
2003年 | 74篇 |
2002年 | 60篇 |
2001年 | 47篇 |
2000年 | 38篇 |
1999年 | 34篇 |
1998年 | 14篇 |
1997年 | 11篇 |
1996年 | 19篇 |
1995年 | 8篇 |
1994年 | 7篇 |
1993年 | 9篇 |
1992年 | 23篇 |
1991年 | 17篇 |
1990年 | 16篇 |
1989年 | 12篇 |
1988年 | 22篇 |
1987年 | 13篇 |
1986年 | 11篇 |
1985年 | 17篇 |
1984年 | 7篇 |
1983年 | 8篇 |
1982年 | 4篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1972年 | 1篇 |
1969年 | 1篇 |
1968年 | 4篇 |
1964年 | 1篇 |
排序方式: 共有2227条查询结果,搜索用时 15 毫秒
31.
32.
33.
Nguyen Van Vinh Chau Nguyen Thi Thu Hong Nghiem My Ngoc Tran Tan Thanh Phan Nguyen Quoc Khanh Lam Anh Nguyet Le Nguyen Truc Nhu Nguyen Thi Han Ny Dinh Nguyen Huy Man Vu Thi Ty Hang Nguyen Thanh Phong Nguyen Thi Hong Que Pham Thi Tuyen Tran Nguyen Hoang Tu Tran Tinh Hien Ngo Ngoc Quang Minh Le Manh Hung Nguyen Thanh Truong Lam Minh Yen H. Rogier van Doorn Nguyen Thanh Dung Guy Thwaites Nguyen Tri Dung Le Van Tan for the OUCRU COVID- research group 《Emerging infectious diseases》2021,27(1):310
34.
Douglass A Morrison Hoang Thai Steven Goldman Edward Felix Joseph Hernandez 《Catheterization and cardiovascular interventions》2006,67(4):571-579
We hypothesized that the use of stents and aggressive adjunctive pharmacotherapies has been associated with lower rates of complicating myocardial infarction (MI) and improved long-term outcomes compared to either previous balloon-only percutaneous coronary intervention (PCI) or atheroablative intervention for lesions of or through saphenous vein grafts (SVGs) and/or internal mammary arteries (IMAs). PCI of SVG has been complicated by relatively high rates of procedural MI and less favorable long-term outcomes than native vessel PCI, stimulating the development and application of an array of technologies. This study was based on retrospective review of stent-era (1999-2004) 5-year experience of a single center with 95 SVG procedures in 85 patients and 20 IMA procedures in 20 patients. These cases were compared with the previously published experience of one of the operators during the balloon-only period and literature review of the application of multiple technologies to SVG intervention, as well as consideration of the reoperation alternative. There was one in-hospital death each in the SVG cohort (1%) and in the IMA cohort (5%). There were SIX procedural MIs (6%), defined by total CK > normal, and 19 procedural MIs (20%) based on troponin-I > 1.0. Follow-up has been from 4 months to 5 years (average, 2.5 years), with 91% survival and one late CABG in the IMA group. SVG PCI with stents and adjunctive pharmacotherapies is associated with relatively low rates of procedural MI and favorable long-term outcomes. 相似文献
35.
36.
Antibiotic therapy for inpatients with community‐acquired pneumonia in a developing country
下载免费PDF全文
![点击此处可从《Pharmacoepidemiology and drug safety》网站下载免费的PDF全文](/ch/ext_images/free.gif)
37.
38.
39.
Effects of interleukin-11 on the proliferation and cell cycle status of myeloid leukemic cells 总被引:1,自引:0,他引:1
Interleukin-11 (IL-11) is a pleiotropic cytokine with effects on many different targets. Within the hematopoietic system, the effects of IL- 11 are largely manifest only through combination with other cytokines, including IL-3 and Steel factor (SF). In the present study, we addressed the question of IL-11 responsiveness within the different types of human leukemic cells, as well as the mechanism of action of IL- 11 at the cellular level. Analysis of a panel of samples from different patients with acute myeloblastic leukemia (AML) and myeloid leukemic cell lines indicated that IL-11 alone was ineffective in supporting myeloid leukemic cell growth but frequently enhanced growth supported by IL-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), or SF. In contrast, three acute pre-B lymphocytic leukemia (pre-B-ALL) and two acute T lymphocytic leukemia (T-ALL) lines failed to respond to IL- 11 alone or when combined with other cytokines. The growth enhancement of IL-11 among the AML patient samples was dose dependent and remarkably constant with half-efficient concentrations in the range of 0.3 to 0.4 ng/mL. The thymidine suicide studies with the patient samples revealed that 40% to 50% of the blast cells were in S-phase when exposed for 16 hours to IL-3 and this level was increased to 70% to 90% in response to either IL-11 or IL-6. Our data suggest that the latter two interleukins act synergistically with the direct mitogenic factor, IL-3, in triggering AML blast-cell proliferation. Detailed analysis with several patient samples further revealed that SF and IL- 11 both enhance IL-3-supported clonogenic growth of AML blasts and the combination of all three growth factors yields optimal growth. In contrast, IL-6 does not further enhance the effect of IL-11. These results indicate that SF and IL-11 enhance IL-3-dependent clonogenic growth through two distinct pathways, whereas IL-6 and IL-11 may trigger the same pathway. 相似文献
40.
Yeong Zen Chua Hoang Tam Do Christoph Schick Dzmitry Zaitsau Christoph Held 《RSC advances》2018,8(12):6365
The properties of melting are required for the prediction of solubility of solid compounds. Unfortunately, direct determination of the enthalpy of fusion and melting temperature by using conventional DSC or adiabatic calorimetry is often not possible for biological compounds due to decomposition during the measurement. To overcome this, fast scanning calorimetry (FSC) with scanning rates up to 2 × 104 K s−1 was used in this work to measure the melting parameters for l-alanine and glycine. The enthalpy of fusion and melting temperature (extrapolated to zero heating rate) were ΔfusH = (22 ± 5) kJ mol−1 and Tfus = (608 ± 9) K for l-alanine, and ΔfusH = (21 ± 4) kJ mol−1 and Tfus = (569 ± 7) K for glycine. These melting properties were used in the modeling framework PC-SAFT to predict amino-acid solubility in water. The pure-component PC-SAFT parameters and one binary parameter were taken from literature, in which these parameters were fitted to solubility-independent thermodynamic properties such as osmotic coefficients or mixture densities. It was shown that this allowed accurately predicting amino-acid solubility in water over a broad temperature range. The combined methodology of PC-SAFT and FSC proposed in this work opens the door for predicting solubility of molecules that decompose before melting.New experimental melting properties combined with PC-SAFT allow quantitative solubility predictions of amino acids in water. 相似文献