全文获取类型
收费全文 | 33880篇 |
免费 | 1544篇 |
国内免费 | 135篇 |
专业分类
耳鼻咽喉 | 261篇 |
儿科学 | 531篇 |
妇产科学 | 418篇 |
基础医学 | 4497篇 |
口腔科学 | 1015篇 |
临床医学 | 2318篇 |
内科学 | 8574篇 |
皮肤病学 | 765篇 |
神经病学 | 2442篇 |
特种医学 | 1251篇 |
外科学 | 5530篇 |
综合类 | 138篇 |
一般理论 | 1篇 |
预防医学 | 1191篇 |
眼科学 | 619篇 |
药学 | 2340篇 |
中国医学 | 70篇 |
肿瘤学 | 3598篇 |
出版年
2022年 | 326篇 |
2021年 | 582篇 |
2020年 | 282篇 |
2019年 | 394篇 |
2018年 | 540篇 |
2017年 | 429篇 |
2016年 | 518篇 |
2015年 | 523篇 |
2014年 | 709篇 |
2013年 | 869篇 |
2012年 | 1370篇 |
2011年 | 1567篇 |
2010年 | 818篇 |
2009年 | 794篇 |
2008年 | 1378篇 |
2007年 | 1516篇 |
2006年 | 1573篇 |
2005年 | 1552篇 |
2004年 | 1438篇 |
2003年 | 1533篇 |
2002年 | 1592篇 |
2001年 | 1447篇 |
2000年 | 1448篇 |
1999年 | 1252篇 |
1998年 | 466篇 |
1997年 | 343篇 |
1996年 | 311篇 |
1995年 | 267篇 |
1994年 | 231篇 |
1993年 | 227篇 |
1992年 | 907篇 |
1991年 | 807篇 |
1990年 | 734篇 |
1989年 | 745篇 |
1988年 | 679篇 |
1987年 | 688篇 |
1986年 | 605篇 |
1985年 | 573篇 |
1984年 | 368篇 |
1983年 | 309篇 |
1982年 | 159篇 |
1979年 | 243篇 |
1978年 | 182篇 |
1977年 | 152篇 |
1975年 | 153篇 |
1974年 | 155篇 |
1973年 | 169篇 |
1970年 | 151篇 |
1969年 | 154篇 |
1967年 | 155篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
32.
33.
S-8666, [6, 7-dichloro-5-(N, N-dimethylsulfamoyl)-2, 3-dihydrobenzofurancarboxylic acid] is a potent diuretic with uricosuric action. Although the major site of action of S-8666 has been proven by the in vitro microperfusion study to be the thick ascending limb of Henle's loop, clearance studies in the rat suggested that this drug has an additional thiazide-like action. To provide direct evidence that S-8666 acts also on distal nephron segments, we examined effect of S-8666 on Cl- flux across the rabbit connecting tubule perfused in vitro. The drug suppressed the lumen-to-bath Cl- flux by 96 +/- 41 (S.E.)pmol.mm-1.min-1 (n = 9) without affecting transmural voltage. To demonstrate that S-8666 acts on the connecting tubule cell, the target of thiazide diuretics, we compared effects of S-8666 and trichlormethiazide on the basolateral membrane voltage of the connecting tubule cell. Both drugs added to the lumen caused a small but significant hyperpolarization of the basolateral membrane without affecting transmural voltage. We conclude that S-8666 is a unique uricosuric diuretic having actions on both thick ascending limb of Henle's loop and connecting tubule. 相似文献
34.
Kunihiro Ichinose Mitsuru Nakamura Kenji Takezawa Ichiro Masutomi Yoichi Shima Yoko Hirayama Kahoko Sorimachi Teruhiko Shimizu Hiroyo Ishikawa Namiko Kaji Sayaka Nakajima Michiko Wataru Shiho Nishigaki Hiroshi Suwa Yosuke Toyama Masaki Okumura Yoshikazu Ishitsuka Ken Shimizu Kazuya Kokubo Kenji Sasaki Shodai Saito 《Seishin shinkeigaku zasshi》2006,108(9):945-954
35.
Kazuo Yamakawa Masashi Takanashi Masao Watanabe Noriyuki Nakamura Tomonori Kobayashi Masato Hasegawa Yoshikuni Mizuno Shigeki Tanaka Hideo Mori 《Neuropathology》2006,26(6):586-591
We report on a male patient with Pick disease who had shown severe white matter atrophy and dilatation of the lateral ventricle in the frontal lobe from an early stage. Upon admission to our hospital 2 years after disease onset, the patient showed apathy, and MRI revealed severe atrophy of the cortex and white matter of the frontal lobe. He died at age 74, 11 years after disease onset. Autopsy revealed severe atrophy of the frontal and temporal lobes, severe loss of white matter in the frontal lobe, dilatation of the lateral ventricles, and cortical thinning. Histopathological examination showed severe loss of myelinated fibers in the frontal white matter and severe neuronal loss with gliosis in the frontal and temporal cortices. Many Pick bodies were seen. Our patient had a rare case of Pick disease predominantly affecting the frontal lobe with severe involvement of the white matter from an early stage. This case suggests that myelinated fibers in the white matter as well as cerebral neurons are primarily affected in Pick disease. 相似文献
36.
Shigeo Nakamura Takashi Koshikawa Tsuneko Sato Kayoko Hayashi Taizan Suchi 《Pathology international》1992,42(10):745-750
We describe a 54-year-old woman with primary pulmonary adenocarcinoma showing a characteristic papillary architecture and prominent cilia formation. Immunohistochemically, the tumor cells were positive for carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA) and Leu Ml, and negative for lactoferrin and surfactant apoprotein. An ultrastructural study also indicated differentiation toward bronchial surface epithelial cells. To our knowledge, this type of neoplasm has not been reported as peripheral-type adenocarcinoma of the lung. Acta Pathol Jpn 42: 745–750, 1992. 相似文献
37.
38.
When stimulating the mixed nerve to record evoked potential, both sensory and motor fibers are activated before entering the spinal cord. The N10 potential has been described as an antidromic motor evoked potential based on results obtained by recording at the anterior midneck. In the present study, we examined the changes in latencies of Erb's potential, N10, and N13 by stimulating the median nerve distally at the wrist and proximally at the elbow. The conduction velocity of N10 calculated by the difference between N10 latencies at the two stimulation points was consistent with motor conduction velocity, although N13 conduction velocity estimated by the same method reflected a sensory conduction velocity. A positive relation was also observed between the indirect latency from the stimulation point to the anterior root as calculated using the equation (F - M - 1) / 2 (ms) and the direct latency to the negative peak of the N10 potential. Our data support the notion that N10 represents antidromic motor potential originating in the spinal entry zone of the anterior root. 相似文献
39.
Kazuhiko Kyoshima Susumu Oikawa Miki Kanaji Hideo Zenisaka Takeomi Takizawa Tetsuya Goto Hisayoshi Takasawa Atsushi Watanabe Kazuo Tokushige Keiichi Sakai 《Journal of clinical neuroscience》2003,10(5):571-578
Some chordomas have a very poor prognosis because of their aggressive growth nature, but the efficacy of repeat operations for these cases has not been well documented. This report concerns 3 patients with aggressive chordoma of the clivus, who underwent operations 6 to 12 times over a period of 8 to 17 years because of symptomatic regrowth. Overall mean interval between repeat operations was 18 months with a range from 5 to 57 months and survival times were 9 to19 years after the first surgery. Main symptoms before each operation were diplopia and visual disturbance. Repeat palliative operations by intentional extradural debulking of the tumour to decompress offending neural structures, as well as maximal removal of the tumour, using appropriate skull base approaches, can mitigate progressive symptoms, and may result in better quality and some prolongation of life, although our patients gradually deteriorated neurologically throughout the clinical course. 相似文献
40.
Y Matsuki K Suzuki M Hara A Kitani T Hirose M Harigai M Kawakami N Tanaka M Kawagoe H Nakamura 《Ryūmachi》1992,32(2):154-9; discussion 159-62
Arterial thrombosis is one of the major symptoms of antiphospholipid syndrome (APS). However, thrombosis in a primary branch of the aorta has rarely been reported in APS. We report here a case of APS complicated by thromboses in both the left subclavian artery and the left external iliac vein. A 32-year-old woman was admitted in May, 1990 complaining of no pulse in the left superficial arteries (e.g., left radial artery) for the past 5 years and acute swelling of the left lower extremity. A left ascending phlebography showed an occlusion of the external iliac vein and arteriography revealed obstruction in the left subclavian artery. Collateral circulations were developed at the site of each thrombus. Clotting and immunological studies revealed a prolonged APTT, a high titer of anticardiolipin antibody and lupus anticoagulant positive. We ruled out various diseases and clinical risk factors predisposing to both arterial and venous thromboses. Accordingly, we concluded that both thromboses were based on APS. Following treatment with anticoagulants, aspirin and corticosteroid, the swelling of her left thigh was diminished and the antibody titer was decreased within 3 months. 相似文献