Zeitschriften

Ohne Zusammenfassung     

Zeitschriften

Ohne Zusammenfassung     

Zeitschriften

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Einzelreferate und Buchbesprechungen

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Die Abderhalden-Reaktion Mittels der Quantitativen „Interferometrischen Methode Nach P. Hirsch-Jena“

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Studies to elucidate the mechanism of fenarimol-induced infertility in male rats

Fenarimol (alpha-(2-chlorophenyl)-alpha-(4-chlorophenyl)-5- pyrimidinemethanol a pyrimidine carbinol fungicide, caused a dose-related decrease in male fertility in Wistar rats. The effect was particularly evident in the anatomically normal progeny of dams treated with fenarimol throughout gestation and lactation. Based on the observation that the infertility was associated with the absence of vaginal sperm at the time of mating, the effect appeared to be the result of an absence of male sexual behavior. Fenarimol does not readily cross the placenta but does concentrate in milk, reaching three- to fivefold higher concentrations than those observed in the maternal plasma. These results suggest that fenarimol might be acting to block the perinatal development of male patterns of sexual behavior which involves the action of gonadal steroids within the central nervous system (CNS). To test this hypothesis, [14C]fenarimol was administered to dams and the radioactivity measured in the brains of the neonates. Radioactivity in the hypothalamus was three- to fourfold higher and the half-life four times longer than that observed in the remainder of the brain. Since the hypothalamus is believed to play a key role in the development and expression of male sexual behavior, it appears likely that fenarimol is acting centrally to decrease male sexual behavior, thereby decreasing male fertility.     

Anforderungs- und Qualifikationsprofil an den Notarzt in der Telenotfallmedizin

The increasing shortage of emergency medical physicians combined with an increasing number of rescue missions—partially due to demographic changes—makes it necessary to use available resources in emergency medical services (EMS) in a demand-optimized manner. This goal can be achieved by establishing a tele-EMS physician in conjunction with a comprehensive telemedicine system that allows transmission of vital data in real time, 12-lead Electrocardiogramm (ECG), voice, images, and video. The advantage of a tele-EMS physician is that the therapy-free interval will be shortened and a highly-qualified support of nonmedical as well as medical personnel can be provided, while being in compliance with German law. However, to achieve a high-quality standard, a defined requirement profile is necessary. The tele-EMS physician must have extensive experience combined with sound knowledge in the field of emergency medicine as well as the ability to lead checklist-based, guideline-oriented patient care. The communication of a working diagnosis in the shortest possible time by interpreting of information provided and situation-dependent, goal-oriented questions is required. In addition, confidence in the rescue team regarding the delegation of actions and administration of drugs is necessary.