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61.
Nakagoe T Sawai T Tsuji T Jibiki MA Nanashima A Yamaguchi H Yasutake T Ayabe H 《Hepato-gastroenterology》2003,50(51):704-708
BACKGROUND/AIMS: Minimally invasive surgery, with its advantages of early return to normal activity and good cosmetic results, is an important goal in the treatment of patients with mucosal ulcerative colitis. The aim of this study was to compare outcomes utilizing a mini-laparotomy approach to total abdominal colectomy for mucosal ulcerative colitis with those of the conventional approach. METHODOLOGY: Eleven patients scheduled to undergo the first (total abdominal colectomy) of a 2 or 3-stage operation for mucosal ulcerative colitis via a mini-laparotomy between 1999 and 2001 were prospectively studied. The mini-laparotomy described here involves total abdominal colectomy performed through a skin incision shorter than 7 cm. Seven similar patients who underwent conventional laparotomy between 1995 and 1998 served as the control group. RESULTS: The mini-laparotomy approach was accomplished in 9 patients (81.8%). Patient characteristics between cases and controls were similar. Postoperative intervals until standing, walking, flatus, urinary catheter removal, and tolerance of solid diet were significantly shorter in the mini-laparotomy group (P = 0.031, P = 0.023, P = 0.0033, P = 0.0093, and P = 0.023, respectively). CONCLUSIONS: A mini-laparotomy approach to total abdominal colectomy appears feasible and safe in selected patient with mucosal ulcerative colitis and poses an attractive alternative to conventional laparotomy in patients similar to those presented here. 相似文献
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64.
Yoshiyuki Tamura Shunsuke Orino Yoshiaki Saijyo Tetsuo Nishimoto Norio Nagase Hiroyoshi Mori 《Heart and vessels》1986,2(4):202-207
Summary The relations of the light chains of myosins of the atria, ventricles, and atrioventricular conducting tissue (specialized myocardial tissue) and the distribution of the light chains of myosin in different regions of the atrioventricular conducting tissue in bovine heart were examined. Two-dimensional gel electrophoresis showed that the atrial and ventricular myosins each had two light chains (LC1 and LC2). Ventricular LC1 differed from atrial LC1, but ventricular LC2 corresponded to atrial LC2. The specialized myocardial tissue myosin had three light chains (named here SL1, SL2, and SL3). SL1 comigrated with ventricular LC1, SL2 with atrial LC1, and SL3 with ventricular LC2 and atrial LC2. The compositions of the three light chains of myosins in various regions of the atrioventricular conducting tissue were determined by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis. The percentage proportion of SL1 decreased in the order—atrioventricular node (AVN), right and left bundle branches (RLBB), His bundle (HIS), false tendon (FT) myosin; while the percentage proportion of SL2 decreased in the order—FT and HIS, RLBB, AVN myosin. The percentages of SL3 in these four regions were similar. The Ca2+-activated ATPase activity of myosin was highest in the AVN and lowest in the FT. The activities in the HIS and RLBB were intermediate between those in the AVN and FT. Thus, the composition of the light chains and the Ca2+-activated ATPase activity were different in various regions of the atrioventricular conducting tissue. 相似文献
65.
Hiroyoshi Furukawa M.D. Tsuyoshi Hara Tetsushi Taniguchi 《Journal of gastroenterology》1992,27(1):102-107
A 66-year-old Japanese woman was admitted to our hospital with upper right quadrant pain and jaundice. Laboratory data indicated
the presence of obstructive jaundice. A diagnosis of cholecystocholedocholithiasis was made by ultrasonography. Endoscopic
retrograde cholangiography revealed choledochal stones with septum formation in a portion of the common hepatic duct up to
where an anomalous bile duct drained from the caudate lobe of the liver. We performed a cholecystectomy, T-tube drainage,
and partial resection of the septum when these findings were confirmed at surgery. Histological examination of the removed
septum showed fibrous stroma under atrophic mucosa. To our knowledge, this is the eighteenth reported case in Japan of septum
formation of the bile duct. However, no other such case to date has been seen combined with an anomalous hepatic duct of the
caudate lobe of the liver. Selective cholangiography by choledochoscope and computed tomography with a thin guide-wire inserted
to the bile duct were useful in confirming the origin of the anomalous bile duct. This case may serve as further evidence
of the assumption that septum formation of the common (hepatic) bile duct is a malformation of congenital origin.
An erratum to this article is available at . 相似文献
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Ricardo Petraco Rasha Al-Lamee Matthias Gotberg Andrew Sharp Farrel Hellig Sukhjinder S. Nijjer Mauro Echavarria-Pinto Tim P. van de Hoef Sayan Sen Nobuhiro Tanaka Eric Van Belle Waldemar Bojara Kunihiro Sakoda Martin Mates Ciro Indolfi Salvatore De Rosa Christian J. Vrints Steven Haine Hiroyoshi Yokoi Flavio L. Ribichini Martjin Meuwissen Hitoshi Matsuo Luc Janssens Ueno Katsumi Carlo Di Mario Javier Escaned Jan Piek Justin E. Davies 《American heart journal》2014
68.
69.
Hosen N Ichihara H Mugitani A Aoyama Y Fukuda Y Kishida S Matsuoka Y Nakajima H Kawakami M Yamagami T Fuji S Tamaki H Nakao T Nishida S Tsuboi A Iida S Hino M Oka Y Oji Y Sugiyama H 《British journal of haematology》2012,156(2):213-224
Monoclonal antibody (mAb) drugs are desirable for the improvement of multiple myeloma (MM) treatment. In this study, we found for the first time that CD48 was highly expressed on MM plasma cells. In 22 out of 24 MM patients, CD48 was expressed on more than 90% of MM plasma cells at significantly higher levels than it was on normal lymphocytes and monocytes. CD48 was only weakly expressed on some CD34(+) haematopoietic stem/progenitor cells, and not expressed on erythrocytes or platelets. We next examined whether CD48 could serve as a target antigen for mAb therapy against MM. A newly generated in-house anti-CD48 mAb induced mild antibody-dependent cell-mediated cytotoxicity and marked complement-dependent cytotoxicity against not only MM cell lines but also primary MM plasma cells in vitro. Administration of the anti-CD48 mAb significantly inhibited tumour growth in severe combined immunodeficient mice inoculated subcutaneously with MM cells. Furthermore, anti-CD48 mAb treatment inhibited growth of MM cells transplanted directly into murine bone marrow. Finally and importantly, we demonstrated that the anti-CD48 mAb did not damage normal CD34(+) haematopoietic stem/progenitor cells. These results suggest that the anti-CD48 mAb has the potential to become an effective therapeutic mAb against MM. 相似文献
70.
Doi H Iyer TK Carpenter E Li H Chang KM Vonderheide RH Kaplan DE 《Hepatology (Baltimore, Md.)》2012,55(3):709-719
Chronic hepatitis C virus (HCV) infection is a leading cause of cirrhosis and hepatocellular carcinoma (HCC). Both advanced solid tumors and HCV have previously been associated with memory B-cell dysfunction. In this study, we sought to dissect the effect of viral infection, cirrhosis, and liver cancer on memory B-cell frequency and function in the spectrum of HCV disease. Peripheral blood from healthy donors, HCV-infected patients with F1-F2 liver fibrosis, HCV-infected patients with cirrhosis, patients with HCV-related HCC, and non-HCV-infected cirrhotics were assessed for B-cell phenotype by flow cytometry. Isolated B cells were stimulated with anti-cluster of differentiation (CD)40 antibodies and Toll-like receptor (TLR)9 agonist for assessment of costimulation marker expression, cytokine production, immunoglobulin (Ig) production, and CD4(+) T-cell allostimulatory capacity. CD27(+) memory B cells and, more specifically, CD27(+) IgM(+) B cells were markedly less frequent in cirrhotic patients independent of HCV infection. Circulating B cells in cirrhotics were hyporesponsive to CD40/TLR9 activation, as characterized by CD70 up-regulation, tumor necrosis factor beta secretion, IgG production, and T-cell allostimulation. Last, blockade of TLR4 and TLR9 signaling abrogated the activation of healthy donor B cells by cirrhotic plasma, suggesting a role for bacterial translocation in driving B-cell changes in cirrhosis. CONCLUSION: Profound abnormalities in B-cell phenotype and function occur in cirrhosis independent of HCV infection. These B-cell defects may explain, in part, the vaccine hyporesponsiveness and susceptibility to bacterial infection in this population. 相似文献