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991.
Takagawa R Kunisaki C Makino H Nagano Y Fujii S Kimura J Kosaka T Ono HA Akiyama H Endo I 《Journal of chemotherapy (Florence, Italy)》2011,23(1):44-48
The purpose of this study was to clarify the efficacy and safety of docetaxel and cisplatin as second-line treatment for patients with S-1 refractory advanced gastric cancer. Between 1999 and 2006, 32 patients received docetaxel (60 mg/m2) and cisplatin (60 mg/m2) (Dp regimen) on day 1 every 3 weeks. This regimen was repeated at least three times at 3-week intervals until disease progression or unacceptable toxicity was detected. The overall response rate was 21.9%. Seven patients showed partial response, 17 showed stable disease and 8 showed disease progression. The median survival time was 12.3 months after the start of the first-line treatment. The median survival time and time to progression following the DP regimen was 7.8 months and 4.0 months, respectively. The major adverse effects were leukopenia and neutropnea. Non-hematological toxicities were generally mild to moderate and controllable. this study showed satisfactory therapeutic outcomes for patients with gastric cancer refractory to S- 1 chemotherapy. 相似文献
992.
T. Sugai M. Yoshizawa T. Kobayashi K. Ono R. Takagi N. Kitamura T. Okiji C. Saito 《International journal of oral and maxillofacial surgery》2010,39(12):1193-1203
Autotransplantation is often performed to replace a missing tooth, but tooth autotransplantation has been reported in fewer teeth with complete root formation than those with incomplete root formation. The aim of this prospective study was to evaluate the factors that affect the prognosis of autotransplantation of teeth with complete root formation. 109 patients with 117 transplants were studied. Of the 117 transplants investigated, 14 (12%) failed during the observation period. The overall 1-year survival rate was 96%; the 5-year survival rate was 84%. The major causes of failure were unsuccessful initial healing and replacement root resorption with periodontal inflammation. Factors significantly associated with unsuccessful transplantation, in single factor analysis, were age 40 years or more, molar tooth as donor, probing pocket depth to 4 mm or more, history of root canal treatment, multi-rooted teeth and fixation with sutures. Pocket depth of 4 mm or more and history of root canal treatment appeared to increase the risk of unsuccessful transplantation in multivariate analysis. It is suggested that the pocket depth of the donor tooth and history of root canal treatment are related to the healing of paratransplantal tissue and root resorption. 相似文献
993.
Objective
This study evaluated the interfacial quality of sound and caries-affected primary tooth dentin bonded with a self-reinforcing one-step self-etch adhesive.Methods
Non-carious, sound dentin was prepared with water-cooled high-speed diamond burs. Caries-infected dentin was removed with water-cooled low-speed round steel burs and hand instrument. Dentin was bonded with Bond Force (Tokuyama Dental). A nano-indentation tester was employed for determination of hardness (H) and Young's modulus (Y) of resin–dentin interface. Similar resin–dentin interfaces were examined with a SEM/EDX, and with a TEM using ammoniacal silver nitrate tracer for nanoleakage.Results
In the comparison of the H and Y values between the interfacial dentin and the underlying mineralized dentin, no significant difference was seen in caries-affected dentin, however, the values of the interfacial dentin were significantly lower in sound dentin. The H value of the interfacial dentin of sound dentin was significantly lower than that of caries-affected dentin with significantly higher Ca content. No significant difference was observed in the Y values of the interfacial dentin of the two substrates. For both sound and caries-affected dentin, TEM revealed silver deposits in the interfacial dentin and adhesive layer, and smear layer remained within the resin–dentin interface. However, Ca and P contents of the adhesive layer at 10 μm above the dentin surface were the same as those present in the interfacial dentin.Conclusions
Both for sound teeth and caries teeth, Bond Force does not prevent the nanoleakage along the resin–dentin interface. 相似文献994.
995.
996.
997.
L Kang MQ Zheng M Morishima Y Wang T Kaku K Ono 《British journal of pharmacology》2009,157(3):404-414
Background and purpose:
Bepridil is an anti-arrhythmic agent with anti-electrical remodelling effects that target many cardiac ion channels, including the voltage-gated Na+ channel. However, long-term effects of bepridil on the Na+ channel remain unclear. We explored the long-term effect of bepridil on the Na+ channel in isolated neonatal rat cardiomyocytes and in a heterologous expression system of human Nav1.5 channel.Experimental approach:
Na+ currents were recorded by whole-cell voltage-clamp technique. Na+ channel message and protein were evaluated by real-time RT-PCR and Western blot analysis.Key results:
Treatment of cardiomyocytes with 10 µmol·L−1 bepridil for 24 h augmented Na+ channel current (INa) in a dose- and time-dependent manner. This long-term effect of bepridil was mimicked or masked by application of W-7, a calmodulin inhibitor, but not KN93 [2-[N-(2-hydroxyethyl)-N-(4-methoxy benzenesulphonyl)]-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine], a Ca2+/calmodulin-dependent kinase inhibitor. During inhibition of protein synthesis by cycloheximide, the INa increase due to bepridil was larger than the increase without cycloheximide. Bepridil and W-7 significantly slowed the time course of Nav1.5 protein degradation in neonatal cardiomyocytes, although the mRNA levels of Nav1.5 were not modified. Bepridil and W-7 did not increase INa any further in the presence of the proteasome inhibitor MG132 [N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide]. Bepridil, W-7 and MG132 but not KN93 significantly decreased 20S proteasome activity in a concentration-dependent manner.Conclusions and implications:
We conclude that long-term exposure of cardiomyocytes to bepridil at therapeutic concentrations inhibits calmodulin action, which decreased degradation of the Nav1.5 α-subunit, which in turn increased Na+ current. 相似文献998.
999.
1000.
Osamu Kimura Shigeru Ono Taizo Furukawa Koji Higuchi Eiichi Deguchi Naomi Iwai 《Journal of pediatric surgery》2009,44(8):1564-466