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41.
S. Nakasu Y. Nakasu M. Nakajima M. Yokoyama M. Matsuda J. Handa 《Acta neurochirurgica》1996,138(6):763-770
Summary Cell kinetic study plays an important role in treatment planning of brain tumour patients. MIB-1 antibody has recently become available, which detects Ki-67 antigen even in the formalin-fixed paraffin-embedded specimens. We performed MIB-1 immunostaining in 50 meningiomas and 50 neurinomas, and estimated the cell cycle time (tc) and potential doubling time (Tpot) from MIB-1 staining index (MIB-1 SI) and mitotic index (MI). MIB-1 SI logarithmically correlated with MI in both meningiomas and neurinomas. The tc and the Tpot were expressed as a function of the mitosis time (tm), while the tm is known to be around one hour and not exceeding two hours. When the tm was assumed to be one hour, the average tcs of meningiomas and neurinomas were 6.53±3.56 days and 7.67±3.27 days, respectively. The Tpots were447 × (MIB-1 SI)–1.29 × tm in meningiomas, and490 × (MIB-1 SI)
–0.98
× tm in neurinomas.The tumour doubling times (Tds) were calculated from serial imaging studies in 22 neurinomas and 15 meningiomas. The Tds were formulated as794 × (MIB-1 SI)
–0.83 in meningiomas and1380 × (MIB-1 SI)
–0.97 in neurinomas. Most of the Tds correlated well with the Tpots in meningiomas and neurinomas, and exceeded values of the Tpot when the tm is assumed to be one hour, although a few tumours showed unexpectedly longer Tds. The Tpot and the tc estimated from MIB-1 SI and MI are clinically useful parameters for predicting the growth potential of meningiomas and neurinomas where no other simple methods are available. 相似文献
42.
Natural interferon enhances expression of placental alkaline phosphatase in human seminoma xenograft
T. Imao K. Koshida H. Konaka T. Uchibayashi K. Yokoyama K. Hirano M. Namiki 《Urological research》1998,26(6):377-382
The purpose of this study was to investigate the effect of natural interferon (IFN) on the expression of placental alkaline
phosphatase (PLAP) in a human seminoma xenograft in severe combined immunodeficient mice. Mice were injected intramuscularly
with 3 × 105 U/mouse of IFN, twice a day, for five consecutive days. A significant increase in PLAP level of the xenografts followed IFN
treatment. A radiolabeled anti-PLAP monoclonal antibody (MAb) was intravenously injected on the first day of IFN administration
in order to determine if IFN has the potential to enhance the efficacy of an anti-PLAP MAb in the detection of seminoma. Enhanced
retention of the anti-PLAP MAb was observed at 7 and 11 days after MAb administration. Thus, IFN treatment appears to have
some effect on the efficacy of the anti-PLAP MAb in the detection of seminoma xenografts.
Received: 26 September 1997 / Accepted: 23 April 1998 相似文献
43.
Kazunari Okada Yang Il Kim Kimihiro Nakashima Izuru Tada Takanori Yoshida Michio Kobayashi Shigeo Yokoyama 《Surgery today》1993,23(7):626-631
A case of small fibrolamellar hepatocellular carcinoma (HCC) coexistent with a HCC of common type is herein reported. A 56-year-old man was diagnosed as having multi-nodular type HCC with liver cirrhosis. The serum alpha-fetoprotein (AFP) level was slightly increased. The patient underwent a partial caudate lobectomy and lateral segmentectomy. Histologically, both resected tumors were small HCCs measuring less than 2 cm in diameter. One was a fibrolamellar type located in the caudate lobe, while the other was the common type in the lateral segment of the liver. Positive immunohistochemical staining for AFP was observed in the tumor cells of the HCC of common type but was not observed in the fibrolamellar HCC. We also reviewed previously reported cases of fibrolamellar HCC in Japan, and discussed the clinicopathologic implications of this disease. 相似文献
44.
Key words intractable pain - celiac plexus neurolysis - ultrasonography 相似文献
45.
Tatsuya Ishiguro Yoshikatsu Ozaki M. Mitsuo Yokoyama C. Howard Tseng William Chao 《Immunobiology》1980,157(1):24-29
Peripheral blood samples from 52 women including 16 with herpes genitalis and 36 healthy persons were studied to enumerate subpopulations of lymphocytes. T lymphocyte counts were done by SRBC rosette tests and B lymphocytes by immunobead rosette tests using antibody-coated polyacrylamide beads. It was found that the mean percentage of «active T lymphocytes was significantly less in the patients with herpes genitalis than in the controls (herpes genitalis; 13.9 ± 6.8%, controls; 25.0 ± 8.3%, p < 0.001). No difference was noted in the percentage of «total» T lymphocytes, «total» B lymphocytes and subsets of B lymphocytes (IgG-, IgA- and IgM-bearing lymphocytes) between the patients and controls. The present findings suggest that cell-mediated immune function associated with «active» T lymphocytes is suppressed in patients with herpes genitalis. 相似文献
46.
Anaplastic carcinomas in nude mice and in original donor strain rats inoculated with cultured oval cells. 总被引:1,自引:5,他引:1 下载免费PDF全文
H. Yoshimura R. Harris S. Yokoyama S. Takahashi M. A. Sells S. F. Pan B. Lombardi 《The American journal of pathology》1983,110(3):322-332
Male Sprague-Dawley rats were fed for 4-5 weeks a choline-devoid diet containing 0.1% DL-ethionine. Preparations of nonparenchymal epithelial cells, enriched in oval cells, were isolated from the livers of these animals and were placed in culture. Six lines of hepatic epithelial cells were thus established. The lines underwent transformation after several passages, became tumorigenic in nude mice and 3 lines also in rats of the same strain of origin of the isolated cells. The tumors were uniformly highly anaplastic carcinomas. Preliminary morphologic, cytologic, and cytochemical results were consistent with the tumoral cells being hepatocytelike cells. These findings are viewed and discussed in terms of the cellular source, in vivo, of longterm cultures of rat liver epithelial cells, and in relation to a possible role of hepatic nonparenchymal epithelial cells in the process of hepatocellular tumor induction by chemical carcinogens. 相似文献
47.
48.
49.
Kazuo Takayama Kanichi Yagawa Akiko Takahashi Hironori Nishio Morio Sudo Nobuyuki Sasaki Toru Yoshida Masanobu Satoh Hisaaki Abiko Akio Nunokawa Mitsuo Okazaki 《Pathology international》1969,19(4):547-562
A typical case of the D uchenne type of progressive muscular dystrophy with autopsy findings was presented. Changes in the myocardial and smooth muscle of many organs were found, and the skeletal muscles also revealed florid changes.
Histopathological examination of the skeletal muscle was made in detail through light and electron microscopic observation. 相似文献
Histopathological examination of the skeletal muscle was made in detail through light and electron microscopic observation. 相似文献
50.
Massive apoptosis in infantile myofibromatosis. A putative mechanism of tumor regression. 总被引:4,自引:3,他引:4 下载免费PDF全文
Y. Fukasawa H. Ishikura A. Takada S. Yokoyama M. Imamura T. Yoshiki H. Sato 《The American journal of pathology》1994,144(3):480-485
Two cases of solitary infantile myofibromatosis (IM) are presented. Solitary IM are tumors prone to spontaneous regression. Histopathologically, several tumor lobules in our IM cases had central areas of massive cell death, with nuclear pyknosis, cytoplasmic hyalinization and nuclear fragmentation but without lymphoid or neutrophilic cell infiltration. These central cell death areas consisted of about 40% in case 2 and 50% in case 1 of the entire tumor tissues, respectively. Electron microscopy revealed that the condensed nuclei and cytoplasm were fragmented into "apoptotic bodies", with or without phagocytosis by histiocytes. DNA fragmentation, as evidenced by the terminal deoxy transferase-mediated uptake of biotinylated dUTP, was identified at massive cell death areas on paraffin sections from both cases. A characteristic 180- to 190-bp nucleosomal ladder was detected in DNA obtained from the tumor cells in case 1. The collective evidence suggested that these tumors underwent a central, massive apoptosis. As massive cell death similar to that seen in the present cases has been described in other documented cases of IM, we propose that the spontaneous regression that frequently occurs with this type of tumor may be mediated by massive apoptotic cell death. 相似文献