全文获取类型
收费全文 | 3095篇 |
免费 | 202篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 81篇 |
妇产科学 | 41篇 |
基础医学 | 351篇 |
口腔科学 | 36篇 |
临床医学 | 234篇 |
内科学 | 1113篇 |
皮肤病学 | 56篇 |
神经病学 | 110篇 |
特种医学 | 73篇 |
外科学 | 573篇 |
综合类 | 13篇 |
预防医学 | 76篇 |
眼科学 | 29篇 |
药学 | 182篇 |
中国医学 | 2篇 |
肿瘤学 | 338篇 |
出版年
2023年 | 33篇 |
2022年 | 40篇 |
2021年 | 117篇 |
2020年 | 47篇 |
2019年 | 71篇 |
2018年 | 86篇 |
2017年 | 78篇 |
2016年 | 94篇 |
2015年 | 106篇 |
2014年 | 131篇 |
2013年 | 136篇 |
2012年 | 231篇 |
2011年 | 243篇 |
2010年 | 145篇 |
2009年 | 139篇 |
2008年 | 203篇 |
2007年 | 196篇 |
2006年 | 172篇 |
2005年 | 192篇 |
2004年 | 166篇 |
2003年 | 142篇 |
2002年 | 128篇 |
2001年 | 33篇 |
2000年 | 30篇 |
1999年 | 31篇 |
1998年 | 31篇 |
1997年 | 24篇 |
1996年 | 19篇 |
1995年 | 22篇 |
1994年 | 23篇 |
1993年 | 12篇 |
1992年 | 13篇 |
1991年 | 13篇 |
1990年 | 11篇 |
1989年 | 9篇 |
1988年 | 14篇 |
1987年 | 16篇 |
1986年 | 14篇 |
1985年 | 10篇 |
1984年 | 12篇 |
1983年 | 5篇 |
1981年 | 5篇 |
1980年 | 5篇 |
1979年 | 8篇 |
1978年 | 6篇 |
1977年 | 7篇 |
1975年 | 8篇 |
1974年 | 13篇 |
1973年 | 11篇 |
1972年 | 5篇 |
排序方式: 共有3326条查询结果,搜索用时 125 毫秒
71.
72.
73.
74.
Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis. 总被引:1,自引:0,他引:1
75.
76.
Kosuke Okuwaki Hironori Masutani Hiroshi Imaizumi Tsutomu Yoshida Mitsuhiro Kida Tomohisa Iwai Hiroshi Yamauchi Masayoshi Tadehara Kai Adachi Masafumi Watanabe Takahiro Kurosu Wasaburo Koizumi 《Pancreatology》2019,19(3):419-423
Background/Objectives
A breakthrough in chemotherapy for pancreatic ductal adenocarcinoma (PDAC) may be achieved using precision medicine, which involves identifying cases that are highly likely to respond to a certain treatment and then performing that treatment. BRCAness has been receiving attention as a novel predictor of anticancer drug sensitivity in PDAC, making the screening of BRCAness paramount.Methods
We conducted the first-ever examination of the feasibility of analyzing BRCAness using multiplex ligation-dependent probe amplification (MLPA). Formalin-fixed paraffin-embedded (FFPE) tissue samples obtained via endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) from 20 patients with the highest pancreatic carcinoma cell counts in tissue samples out of 40 consecutive PDAC patients who underwent EUS-FNAB at our hospital were analyzed by MLPA for BRCAness.Results
We were able to accurately analyze BRCAness in 75% of the 20 cases of PDAC using FFPE tissue obtained by EUS-FNAB. BRCAness was observed in one of the 20 cases.Conclusions
In PDAC, analyzing BRCAness by MLPA using FFPE tissue obtained by EUS-FNAB offers the remarkable benefit of yielding results in a short period of time and at a low cost. In addition, this method of BRCAness analysis may prove to be a feasible and effective approach for performing precision medicine. 相似文献77.
Satoshi Taniwaki Makoto Kataoka Hironori Tanaka Yoshiki Mizuno Masao Hirose 《Journal of gastroenterology》1997,32(4):548-552
68-year-old woman presented with abdominal pain and vomiting. After initial conservative therapy, laparotomy showed multiple
ulcers of the ileum, one of which had perforated and adhered to the uterus. The affected segment of the ileum was resected.
Numerous cytomegalic cells, corresponding to endothelia and macrophages, with intranuclear inclusion bodies, were found in
microscopic sections of the ulcerated lesions. These findings were consistent with cytomegalic vasculitis and enteritis.Cytomegalovirus infections of the alimentary tract have been, reported mainly in severely immunocompromised patients or those with predisposing
disorders such as ulcerative colitis; their prognosis is usually poor. In our patient, there was no obvious immunocompromised
state or other gastrointestinal disorders. The postoperative course has been uneventful for 2 years after surgery. The prognosis
ofCytomegalovirus-associated lesions in the alimentary tract may be quite good in the immunocompetent patient. 相似文献
78.
79.
Takagi T Matsuda M Abe M Kobayashi H Fukuhara A Komuro R Kihara S Caslake MJ McMahon A Shepherd J Funahashi T Shimomura I 《Atherosclerosis》2008,196(1):114-121
In the West of Scotland Coronary Prevention Study (WOSCOPS), treatment of hypercholesterolemic men with pravastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, reduced their likelihood to progress to diabetes mellitus by 30%. However, the mechanism of this effect of pravastatin has not been investigated. In the current study, we examined the effect of pravastatin on the development of diabetes in obese diabetic mice, and on the insulin-induced glucose uptake and adiponectin production. Pravastatin treatment attenuated the development of diabetes in db/db and high fat/high sucrose diet-fed C57BL/6J mice. An in vivo glucose transport assay showed that pravastatin upregulated glucose uptake in adipose tissue. Insulin-stimulated glucose uptake was enhanced in primary adipocytes isolated from pravastatin-treated mice. Pravastatin treatment increased adiponectin production in 3T3-L1 adipocytes. Plasma adiponectin levels were significantly increased in pravastatin-treated mice. Analyses of plasma samples from the WOSCOPS biobank indicated a significant increase of plasma adiponectin levels with pravastatin treatment (placebo -0.28+/-0.34 microg/ml versus pravastatin +1.47+/-0.33 microg/ml, p=0.0003). Taken together, our findings suggest that pravastatin may have beneficial effects on adipose tissue, which may partly explain the reduction of the development of diabetes by pravastatin treatment. 相似文献
80.