全文获取类型
收费全文 | 3127篇 |
免费 | 191篇 |
国内免费 | 30篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 83篇 |
妇产科学 | 41篇 |
基础医学 | 351篇 |
口腔科学 | 36篇 |
临床医学 | 239篇 |
内科学 | 1119篇 |
皮肤病学 | 56篇 |
神经病学 | 110篇 |
特种医学 | 73篇 |
外科学 | 575篇 |
综合类 | 13篇 |
预防医学 | 80篇 |
眼科学 | 29篇 |
药学 | 182篇 |
中国医学 | 2篇 |
肿瘤学 | 341篇 |
出版年
2023年 | 40篇 |
2022年 | 52篇 |
2021年 | 117篇 |
2020年 | 47篇 |
2019年 | 71篇 |
2018年 | 86篇 |
2017年 | 78篇 |
2016年 | 94篇 |
2015年 | 106篇 |
2014年 | 131篇 |
2013年 | 136篇 |
2012年 | 231篇 |
2011年 | 243篇 |
2010年 | 145篇 |
2009年 | 139篇 |
2008年 | 203篇 |
2007年 | 196篇 |
2006年 | 172篇 |
2005年 | 192篇 |
2004年 | 166篇 |
2003年 | 142篇 |
2002年 | 128篇 |
2001年 | 33篇 |
2000年 | 30篇 |
1999年 | 31篇 |
1998年 | 31篇 |
1997年 | 24篇 |
1996年 | 19篇 |
1995年 | 22篇 |
1994年 | 23篇 |
1993年 | 12篇 |
1992年 | 13篇 |
1991年 | 13篇 |
1990年 | 11篇 |
1989年 | 9篇 |
1988年 | 14篇 |
1987年 | 16篇 |
1986年 | 14篇 |
1985年 | 10篇 |
1984年 | 12篇 |
1983年 | 5篇 |
1981年 | 5篇 |
1980年 | 5篇 |
1979年 | 8篇 |
1978年 | 6篇 |
1977年 | 7篇 |
1975年 | 8篇 |
1974年 | 13篇 |
1973年 | 11篇 |
1972年 | 5篇 |
排序方式: 共有3348条查询结果,搜索用时 15 毫秒
121.
Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease 总被引:10,自引:0,他引:10
Sumida Y Nakashima T Yoh T Furutani M Hirohama A Kakisaka Y Nakajima Y Ishikawa H Mitsuyoshi H Okanoue T Kashima K Nakamura H Yodoi J 《Journal of hepatology》2003,38(1):32-38
BACKGROUND/AIMS: Thioredoxin (TRX) is a stress-inducible thiol-containing protein. The aim of this study was to evaluate the clinical significance of serum TRX in patients with nonalcoholic steatohepatitis (NASH) or simple steatosis. METHODS: Serum TRX levels were determined using an enzyme-linked immunosorbent assay kit in 25 patients with NASH, 15 patients with simple steatosis, and 17 healthy volunteers. RESULTS: Serum TRX levels (medians and (ranges), ng/ml) were significantly elevated in patients with NASH (60.3 (17.6-104.7)), compared to those in patients with simple steatosis (24.6 (16.6-69.7), P=0.0009) and in healthy controls (23.5 (1.3-50.7), P<0.0001). Serum ferritin levels in patients with NASH were also significantly higher than the levels in patients with simple steatosis. The receiver operating characteristic curve confirmed that serum TRX and ferritin levels were predictors for distinguishing NASH from simple steatosis. Higher grades of histological iron staining were observed in NASH than in simple steatosis. Serum TRX tended to increase in accordance with hepatic iron accumulation and the histological severity in patients with NASH. CONCLUSIONS: The pathogenesis of NASH may be associated with iron-related oxidative stress. The serum TRX level is a parameter for discriminating NASH from simple steatosis as well as a predictor of the severity of NASH. 相似文献
122.
Endoscopic therapy of early gastric cancer 总被引:3,自引:0,他引:3
Endoscopic therapy of early gastric cancer is applicable for differentiated-type mucosal carcinomas that have an extremely low potency of lymph-node metastasis. Among various kinds of endoscopic therapy, endoscopic mucosal resection is the most recommended procedure, because pathological evaluation of affected tissues is available using this method. Recently, endoscopic submucosal dissection, a novel method of endoscopic mucosal resection, has gained interest as a more reliable therapeutic procedure. In the present chapter several issues will be presented on endoscopic therapy for early gastric cancer, including endoscopic diagnosis of early gastric cancer, currently accepted indications of endoscopic therapy, and the possibility of extending the indication and techniques used for mucosal resection. 相似文献
123.
Tomoyuki Akiyama Masahiko Inamori Hiroshi Iida Hironori Mawatari Hiroki Endo Kunihiro Hosono Kyoko Yoneda Koji Fujita Masato Yoneda Hirokazu Takahashi Ayumu Goto Yasunobu Abe Noritoshi Kobayashi Kensuke Kubota Satoru Saito Atsushi Nakajima 《BMC gastroenterology》2008,8(1):1-6
Background
The precise role of capsule endoscopy in the diagnostic algorithm of obscure gastrointestinal bleeding has yet to be determined. Despite the higher diagnostic yield of capsule endoscopy, the actual impact on clinical outcome remains poorly defined. The aim of this study was to evaluate the follow-up results of patients with obscure gastrointestinal bleeding to determine which management strategies after capsule endoscopy reduced rebleeding.Methods
All patients in whom the cause of obscure gastrointestinal bleeding was investigated between May 2004 and March 2007 were studied retrospectively. We evaluated the clinical outcome of patients with obscure gastrointestinal bleeding after capsule endoscopy using the rebleeding rate as the primary outcome.Results
Seventy-seven patients with obscure gastrointestinal bleeding underwent capsule endoscopy. Capsule endoscopy identified clinically significant findings that were thought to be the sources of obscure gastrointestinal bleeding in 58.4% of the patients. The overall rebleeding rate was 36.4%. The rebleeding rate was significantly higher among patients with insignificant findings than among those with significant findings (p = 0.036). Among the patients in whom capsule endoscopy produced significant findings, the rebleeding rate of the patients who underwent therapeutic interventions was significantly lower than that in those who did not undergo intervention (9.5% vs 40.0%, p = 0.046).Conclusion
Follow-up and further aggressive interventions are necessary for patients with obscure gastrointestinal bleeding and significant capsule endoscopy findings to reduce the chance of rebleeding. 相似文献124.
Bhandari RK Taniyama S Kitahashi T Ando H Yamauchi K Zohar Y Ueda H Urano A 《General and comparative endocrinology》2003,130(1):55-63
Gonadotropin-releasing hormone (GnRH) is considered to stimulate secretion of growth hormone (GH), prolactin (PRL), and somatolactin (SL) at particular stages of growth and sexual maturation in teleost fishes. We therefore examined seasonal variation in the pituitary levels of GH/PRL/SL mRNAs, and tried to clarify seasonal changes of responses to GnRH in expression of GH/PRL/SL genes, in the pituitaries of growing and maturing masu salmon (Oncorhynchus masou). Pituitary samples were monthly collected one week after implantation with GnRH analog (GnRHa). The levels of mRNAs encoding GH, PRL, and SL precursors in single pituitaries were determined by a real-time polymerase chain reaction method. The fork lengths and body weights of control and GnRHa-implanted fish of both sexes gradually increased and peaked out in September of 2-year-old (2+) when fish spawned. GnRHa implantation did not stimulate somatic growth, nor elevate gonadosomatic index (GSI) of 1+ and 2+ males, whereas it significantly increased GSI of 2+ females in late August to early September. The GnRHa-implanted 1+ males had higher levels of GH and PRL mRNAs in July, and SL mRNA from June to August than the control males. The levels of GH, PRL, and SL mRNAs in the control and GnRHa-implanted 1+ females, however, did not show any significant changes. Afterward, the PRL mRNA levels elevated in the control 2+ fish of both sexes in spring. GnRHa elevated the GH mRNA levels in both males and females in 2+ winter, and the PRL mRNA levels in females in early spring. Regardless of sex and GnRHa-implantation, the SL mRNA levels increased during sexual maturation. In growing and maturing masu salmon, expression of genes encoding GH, PRL, and SL in the pituitary is thus sensitive to GnRH in particular seasons probably in relation to physiological roles of the hormones. 相似文献
125.
Takashi Morihara Noriyuki Hayashi Mikiko Yokokoji Hiroyasu Akatsu Michael A. Silverman Nobuyuki Kimura Masahiro Sato Yuhki Saito Toshiharu Suzuki Kanta Yanagida Takashi S. Kodama Toshihisa Tanaka Masayasu Okochi Shinji Tagami Hiroaki Kazui Takashi Kudo Ryota Hashimoto Naohiro Itoh Kouhei Nishitomi Yumi Yamaguchi-Kabata Tatsuhiko Tsunoda Hironori Takamura Taiichi Katayama Ryo Kimura Kouzin Kamino Yoshio Hashizume Masatoshi Takeda 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(7):2638-2643
126.
127.
Yasushi Imamura Hirofumi Uto Yasunari Hiramine Kaori Hosoyamada Sho Ijuin Shiro Yoshifuku Hironori Miyahara Shigeho Maenohara Makoto Oketani Akio Ido Hirohito Tsubouchi 《Journal of gastroenterology》2014,49(10):1406-1413
Background
The prevalence of diabetes mellitus (DM) has been increasing. The present study was carried out to examine the relationship between this increase and fatty liver.Methods
Japanese participants who underwent regular health examinations in 1991, 1996, 2001, 2006, and 2011 were enrolled. Fatty liver was diagnosed using ultrasonography. DM was defined as requiring the use of medication for DM, having a fasting blood glucose level ≥126 mg/dl, or hemoglobin A1c level ≥6.5 %.Results
Logistic regression analysis on data from 11,235 participants (6,882 men and 4,271 women) in 2011 revealed that the association between fatty liver and DM was independent of age, body composition, and other confounders [odds ratio (OR) 1.97, 95 % confidence interval (95 % CI) 1.66–2.32 in men, and OR, 3.12; 95 % CI, 2.29–4.26 in women]. In 2006, 5,318 participants did not have DM and were able to be followed up in 2011. Fatty liver in 2006 was an independent predictor of DM in 2011 [OR 1.73 (95 % CI 1.20–2.50) in men, 4.13 (2.16–8.10) in women]. The prevalence of DM increased significantly during the 20-year period examined among both men (6.0, 8.9, 10.0, 10.8, 12.0 %, P < 0.001) and women (3.3, 4.5, 4.2, 4.1, 5.1 %, P = 0.004), accompanied with an increased prevalence of fatty liver among both men (10.8, 26.3, 33.8, 36.7, and 38.0 %, P < 0.001) and women (6.5, 16.7, 22.2, 21.3, and 20.8 %, P < 0.001).Conclusion
Fatty liver independently predicts both present and future DM. Fatty liver may play an important role in the recent increases in the prevalence of DM. 相似文献128.
129.
Tetsurou Yamamoto Sachiko Minamiguchi Yoshiki Watanabe Jun Tsuji Ryo Asato Toshiaki Manabe Hironori Haga 《Head and neck pathology》2014,8(2):198-203
Kimura disease (KD) affecting an unusual site is a diagnostic challenge. We report herein the case of a 62-year-old Japanese woman who presented with swelling of the epiglottis, resulting in airway narrowing. Microscopically, biopsied and resected specimens both revealed lymphoid proliferation of a reactive immunophenotype, accompanied by vascular proliferation, eosinophilic infiltration, and stromal sclerosis. Adjunctive immunohistochemistry with immunoglobulin E in addition to laboratory and histological findings led us to seriously consider a diagnosis of KD. The patient underwent surgical removal with postoperative steroid therapy and has no evidence of recurrence. Our experience suggests that KD is potentially fatal as well as showing difficulty in the histological diagnosis when occurring in the upper respiratory tract, such as the epiglottis. A literature review disclosed that our case is the 11th case so far reported in this location, and that KD of the epiglottis did not show any male preponderance, as seen in other places. 相似文献
130.
Hironori Ochi Ryuichi Ohno Mitsuaki Kubota Ryo Hanyu Kensuke Sakai Yu Sugawara Fumihiro Mukasa Kazuo Kaneko 《International journal of surgery case reports》2014,5(12):1178-1182