全文获取类型
收费全文 | 2286篇 |
免费 | 115篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 22篇 |
妇产科学 | 44篇 |
基础医学 | 256篇 |
口腔科学 | 20篇 |
临床医学 | 173篇 |
内科学 | 768篇 |
皮肤病学 | 45篇 |
神经病学 | 49篇 |
特种医学 | 121篇 |
外科学 | 337篇 |
综合类 | 5篇 |
预防医学 | 39篇 |
眼科学 | 5篇 |
药学 | 178篇 |
中国医学 | 18篇 |
肿瘤学 | 340篇 |
出版年
2024年 | 2篇 |
2023年 | 14篇 |
2022年 | 41篇 |
2021年 | 73篇 |
2020年 | 31篇 |
2019年 | 45篇 |
2018年 | 57篇 |
2017年 | 45篇 |
2016年 | 62篇 |
2015年 | 58篇 |
2014年 | 96篇 |
2013年 | 94篇 |
2012年 | 159篇 |
2011年 | 148篇 |
2010年 | 111篇 |
2009年 | 91篇 |
2008年 | 152篇 |
2007年 | 133篇 |
2006年 | 157篇 |
2005年 | 155篇 |
2004年 | 139篇 |
2003年 | 151篇 |
2002年 | 137篇 |
2001年 | 21篇 |
2000年 | 16篇 |
1999年 | 23篇 |
1998年 | 27篇 |
1997年 | 27篇 |
1996年 | 32篇 |
1995年 | 13篇 |
1994年 | 12篇 |
1993年 | 14篇 |
1992年 | 20篇 |
1991年 | 8篇 |
1990年 | 4篇 |
1989年 | 5篇 |
1988年 | 6篇 |
1986年 | 5篇 |
1985年 | 7篇 |
1984年 | 9篇 |
1983年 | 6篇 |
1982年 | 5篇 |
1981年 | 7篇 |
1980年 | 2篇 |
1978年 | 4篇 |
1977年 | 5篇 |
1975年 | 3篇 |
1972年 | 4篇 |
1971年 | 2篇 |
1970年 | 1篇 |
排序方式: 共有2441条查询结果,搜索用时 15 毫秒
71.
72.
Surgery Today - Procalcitonin (PCT) is an early predictor of bacterial infection. We reviewed the literature and analyzed data on our own patients to assess the value of PCT as a predictor of... 相似文献
73.
Hatem A. Elmezayen Hirohisa Okabe Yoshifumi Baba Toshihiko Yusa Rumi Itoyama Yosuke Nakao Takanobu Yamao Naoki Umzaki Masayo Tsukamoto Yuki Kitano Tatsunori Miyata Kota Arima Hiromitsu Hayashi Katsunori Imai Akira Chikamoto Yo-ichi Yamashita Hideo Baba 《Surgery today》2020,50(6):569-576
Programmed death ligand 1 (PD-L1) is a key target for the treatment of several malignancies. The present study was conducted to clarify the role of serum PD-L1 in hepatocellular carcinoma (HCC). Serum PD-L1 (sPD-L1) was examined by an enzyme-linked immunosorbent assay in 153 patients with HCC who underwent curative hepatectomy at Kumamoto University in 2011–2016. The expression of PD-L1 in tissue (tPD-L1) was investigated by immunohistochemistry. The clinical roles of the PD-L1 expression in both serum and tissue were examined. The sPD-L1 was significantly elevated in HCC patients compared to patients without any malignant or inflammatory disease (234 vs. 93 pg/mL, p < 0.0001). The percentage of the tPD-L1-positive area (%tPD-L1) in the background liver was significantly higher than in the tumor (1.52% vs. 0.48%, p < 0.0001). The %tPD-L1 in the background liver but not in the tumor was significantly correlated with the sPD-L1 level (p = 0.0079). The sPD-L1, %tPD-L1 in the tumor, and %tPD-L1 in the background liver were not correlated with the overall survival after surgery. PD-L1-expressing cells in the background liver, but not in the tumor tissue, appeared to contribute to the sPD-L1 level. The sPD-L1 level may thus not indicate the tumor burden in patients with HCC. 相似文献
74.
Effects of alcohol consumption on multiple hepatocarcinogenesis in patients with fatty liver disease
Yorinari Ochiai M.D. Ph.D Yusuke Kawamura Masahiro Kobayashi Junichi Shindoh Yuta Kobayashi Satoshi Okubo Nozomu Muraishi Akira Kajiwara Soichi Iritani Shunichiro Fujiyama Tetsuya Hosaka Satoshi Saitoh Hitomi Sezaki Norio Akuta Fumitaka Suzuki Yoshiyuki Suzuki Kenji Ikeda Yasuji Arase Masaji Hashimoto Hiromitsu Kumada 《Hepatology research》2021,51(1):62-68
75.
76.
77.
Masuda A Nakamura K Izutsu K Igarashi K Ohkawa R Jona M Higashi K Yokota H Okudaira S Kishimoto T Watanabe T Koike Y Ikeda H Kozai Y Kurokawa M Aoki J Yatomi Y 《British journal of haematology》2008,143(1):60-70
Autotaxin (ATX) is a tumour cell motility-stimulating factor originally isolated from melanoma cell supernatants. ATX is identical to lysophospholipase D, which produces a bioactive lipid mediator, lysophosphatidic acid (LPA), from lysophosphatidylcholine. ATX is overexpressed in various malignancies, including Hodgkin lymphoma, and ATX may stimulate tumour progression via LPA production. The present study measured the serum ATX antigen levels in patients with haematological malignancies using a recently developed automated enzyme immunoassay. The serum ATX antigen levels in patients with B-cell neoplasms, especially follicular lymphoma (FL), were higher than those in healthy subjects. Serum ATX antigen levels in FL patients were associated with tumour burden and changed in parallel with the patients' clinical courses. The serum ATX antigen levels were little affected by inflammation, unlike the soluble interleukin-2 receptor and beta2-microglobulin levels. As expected, the plasma LPA levels in FL patients were correlated with the serum ATX antigen levels. Given that leukaemic tumour cells from FL patients expressed ATX, the shedding of ATX from lymphoma cells probably leads to the elevation of serum ATX antigen levels. Our results suggest that the serum ATX antigen level may be a promising and novel marker for FL. 相似文献
78.
Hirasaki S Fujita K Matsubara M Kanzaki H Yamane H Okuda M Suzuki S Shirakawa A Saeki H 《World journal of gastroenterology : WJG》2008,14(18):2928-2931
We describe an 87-year-old woman with a large ileal gastrointestinal stromal tumor (GIST) causing hemoperitoneum. A CT scan demonstrated a large heterogeneous mass measuring about 13 cm × 11 cm in the pelvis and hemoperitoneum, with a non-uniform enhancement pattern. The mass was diagnosed as a GIST originating from the gastrointestinal tract. She underwent an urgent laparotomy and an ileal GIST with a rupture was found 130 cm from the anal to the Treitz’s ligament. Hemoperitoneum caused by ileal GIST rupture is a rare condition. Bleeding in the large tumor leading to rupture of the capsule might cause hemoperitoneum in the present case. 相似文献
79.
Hirozumi Sawai Akira Yasuda Nobuo Ochi Jiachi Ma Yoichi Matsuo Takehiro Wakasugi Hiroki Takahashi Hitoshi Funahashi Mikinori Sato Hiromitsu Takeyama 《BMC gastroenterology》2008,8(1):56
Background
The tumour suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling. To evaluate the correlation between PTEN expression and clinicopathological characteristics of colorectal cancer patients with and without liver metastases, we investigated PTEN expression in primary colorectal cancer and colorectal cancer liver metastases. 相似文献80.