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31.
Afifi K. Bellanger G. Buyck P. J. Zuurbier S. M. Garcia-Esperon C. Barboza M. A. Costa P. Escudero I. Renard D. Lemmens R. Hinteregger N. Fazekas F. Jimenez-Conde J. Giralt-Steinhauer E. Hiltunen S. Arauz A. Pezzini A. Montaner J. Putaala J. Weimar C. Schlamann Marc Gattringer T. Tatlisumak T. Coutinho J. M. Demaerel P. Thijs V. 《Journal of neurology》2020,267(11):3299-3300
Journal of Neurology - The original version of this article unfortunately contained mistakes. The correct information is given below. 相似文献
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Female rats, trained to discriminate between IP administered 1.2 g/kg ethanol (ETOH) and the saline vehicle (12 ml/kg), did not press the nondrug associated lever in tests with ETOH (0.9 and 1.2 g/kg) plus the purported amethystic imidazo benzodiazepine Ro 15-4513 (3 and 10 mg/kg) as examined at two intervals after ETOH administrations viz. 7.5 and 15 min. The two doses of Ro 15-4513 were administered 5 min prior to ETOH. Response times were increased in tests with the combination. ETOH in expired air was not different in the two drug conditions, i.e., ETOH singly and together with Ro 15-4513, irrespective of the dose combinations examined. Rats trained to press a bar (FR-10 operant behavior) for sweetened water disclosed increases in the time used to obtain the reinforcer after treatments with ETOH and Ro 15-4513. Thus, Ro 15-4513 did not seem to reverse any of the behaviors examined in this study. 相似文献
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Modulation of in vitro eosinophil progenitors by hydrocortisone: role of accessory cells and interleukins 总被引:1,自引:0,他引:1
The growth of human eosinophil progenitors (CFU-Eo) and the modulation of growth by hydrocortisone were studied as functions of the presence of lymphocytes and monocytes in marrow cells under study; and the source of colony-stimulating factors, specifically, media conditioned by macrophage-like cell line, GCT; phytohemagglutinin-stimulated mononuclear cells (PHA-LCM); or the T cell line, MO. CFU-Eo growth was greatest in marrow containing accessory cells as compared to marrow depleted of accessory cells; and in marrow treated with phytohemagglutinin-stimulated leukocyte conditioned media (PHA-LCM) or MO (T cell line)-conditioned medium (MO-CM) as compared with GCT cell- conditioned medium (GCT-CM). Hydrocortisone reproducibly inhibited eosinophil progenitor growth in unfractionated marrow stimulated by GCT- CM. This effect was abrogated by admixing irradiated mononuclear cells or T lymphocytes with the target marrow or by adding interleukin 1 or interleukin 2 (IL-1, IL-2). Inhibition by hydrocortisone did not occur when monocyte and T lymphocyte depleted marrow was studied. Unlike GCT- CM, MO-CM and PHA-LCM stimulated equal proportions of eosinophil progenitors in nondepleted and accessory cell-depleted marrow and demonstrated less hydrocortisone inhibition. However, both GCT-CM and PHA-LCM produced in the presence of hydrocortisone stimulated significantly fewer CFU-Eos in both unfractionated and accessory cell- depleted marrow target populations. These results indicate that the growth of CFU-Eo and inhibition of growth by hydrocortisone is a direct function of a monocyte-T cell interaction and probably is mediated through effects on the production/release of eosinophil colony stimulating factor (Eo-CSF). 相似文献
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Absence of association between an intercellular adhesion molecule 1 gene E469K polymorphism and Alzheimer's disease in Finnish patients 总被引:7,自引:0,他引:7
Mattila KM Hiltunen M Rinne JO Mannermaa A Röyttä M Alafuzoff I Laippala P Soininen H Lehtimäki T 《Neuroscience letters》2003,337(1):61-63
Increased expression of intercellular adhesion molecule 1 (ICAM1), a protein known to contribute to inflammatory responses, has been detected in the brain tissue of patients with Alzheimer's disease (AD) and animals modelled to mimic AD or Parkinson's disease (PD). ICAM1 may, thus, be implicated in the pathogenesis of these disorders. Our purpose was to investigate whether genetic variants of the ICAM1 gene have a role in causing susceptibility to AD and/or PD. We genotyped the E469K polymorphism of ICAM1 in 196 AD, 52 PD and 202 control patients of Finnish origin. The distributions of the genotype and allele frequencies of the polymorphism did not differ significantly between the AD, PD or the control patients. We therefore conclude that the E469K polymorphism of ICAM1 is not a risk factor for AD or PD. 相似文献
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Expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in ischemic skeletal muscle and its regeneration 总被引:11,自引:0,他引:11 下载免费PDF全文
Rissanen TT Vajanto I Hiltunen MO Rutanen J Kettunen MI Niemi M Leppänen P Turunen MP Markkanen JE Arve K Alhava E Kauppinen RA Ylä-Herttuala S 《The American journal of pathology》2002,160(4):1393-1403
Vascular endothelial growth factor (VEGF) is a hypoxia-inducible endothelial cell mitogen and survival factor. Its receptor VEGFR-2 (KDR/Flk-1) mediates these effects. We studied the expression of VEGF and VEGFR-2 in ischemic human and rabbit skeletal muscle by immunohistochemistry and in situ hybridization. Human samples were obtained from eight lower limb amputations because of acute or chronic critical ischemia. In chronically ischemic human skeletal muscle VEGF and VEGFR-2 expression was restricted to atrophic and regenerating skeletal myocytes, whereas in acutely ischemic limbs VEGF and VEGFR-2 were expressed diffusely in the affected muscle. Hypoxia-inducible factor-1alpha was associated with VEGF and VEGFR-2 expression both in acute and chronic ischemia but not in regeneration. Hindlimb ischemia was induced in 20 New Zealand White rabbits by excising the femoral artery. Magnetic resonance imaging and histological sections revealed extensive ischemic damage in the thigh and leg muscles of ischemic rabbit hindlimbs with VEGF expression similar to acute human lower limb ischemia. After 1 and 3 weeks of ischemia VEGF expression was restricted to regenerating myotubes and by 6 weeks regeneration and expression of VEGF was diminished. VEGFR-2 expression was co-localized with VEGF expression in regenerating myotubes. Macrophages and an increased number of capillaries were associated with areas of ischemic muscle expressing VEGF and VEGFR-2. In conclusion, two patterns of VEGF and VEGFR-2 expression in human and rabbit ischemic skeletal muscle are demonstrated. In acute skeletal muscle ischemia VEGF and VEGFR-2 are expressed diffusely in the affected muscle. In chronic skeletal muscle ischemia and in skeletal muscle recovering from ischemia VEGF and VEGFR-2 expression are restricted to atrophic and regenerating muscle cells suggesting the operation of an autocrine pathway that may promote survival and regeneration of myocytes. 相似文献
40.
Genotype-phenotype correlation for nucleotide substitutions in the IgII- IgIII linker of FGFR2 总被引:3,自引:3,他引:3