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71.
Yasunobu Yamashita MD Jun Kato MD PhD Kazuki Ueda MD PhD Yasushi Nakamura MD PhD Hiroko Abe MD Takashi Tamura MD Masahiro Itonaga MD Takeichi Yoshida MD PhD Hiroki Maeda MD Kosaku Moribata MD PhD Toru Niwa MD PhD Takao Maekita MD PhD Mikitaka Iguchi MD PhD Hideyuki Tamai MD PhD Masao Ichinose MD PhD 《Journal of clinical ultrasound : JCU》2015,43(2):89-97
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Development and internal validation of a nomogram for predicting stone‐free status after flexible ureteroscopy for renal stones 下载免费PDF全文
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Hepatic Circulation and Hepatic Oxygen Consumption in Alcoholic and Nonalcoholic Fatty Liver 总被引:2,自引:0,他引:2
Akinori Kasahara Norio Hayashi Yutaka Sasaki Kazuhiro Katayama Michikazu Kono Takashi Yashima Hideyuki Fusamoto Nobuhiro Sato Takenobu Kamada 《The American journal of gastroenterology》1988,83(8):846-849
The purpose of this study was to determine the differences in hepatic circulation and oxygen consumption in two groups: those with nonalcoholic obesity-related fatty live and those with alcoholic fatty liver. Although the histological degree of fatty infiltration was equal in the two groups, the delta Er569-650, as an index of the regional liver blood flow estimated by spectrophotometric method, was significantly lower in alcoholic fatty liver than in nonalcoholic fatty liver, and the in vivo hepatic oxygen consumption (VO2), also determined by hepatic reflectance spectrophotometry during peritoneoscopy, tended to be lower in alcoholic fatty liver than in nonalcoholic fatty liver. The oxygen saturation of hemoglobin in local liver blood (SO2) was, however, significantly higher in alcoholic fatty liver than in nonalcoholic fatty liver. These results suggest that an increase in oxygen extraction to maintain oxygen consumption, which was indicated by the lowering of the SO2, was not found in alcoholic fatty liver, in spite of a reduction of oxygen supply to the liver. It is concluded that the impairment of hepatic circulation and hepatic oxygen consumption was more serious in alcoholic fatty liver than in nonalcoholic fatty liver, possibly contributing to a different prognosis for the two forms of fatty liver. 相似文献
74.
Eiji Masuda Sunao Kawano Kouichi Nagano Shingo Tsuji Yoshitaka Ishigami Nobuhiko Hayashi Masahiko Tsujii Yoshiaki Sasayama Tomoki Michida Hideyuki Fusamoto et al. 《Journal of gastroenterology》1991,26(Z3):81-82
The effects of ethanol on gastric vasculature in isolated vascularly perfused rabbit stomach was investigated. The isolated
stomach was perfused with Krebs-Henseleit solution containing 3% dextran bubbled with 95% O2 and 5% CO2 at a rate of 12 ml/min. After mixture and perfusion of 10 mM to 400 mM of ethanol, perfusion pressure and endothelin-1 concentration
in effluent from gastric vasculature were measured. Perfusion pressure and endothelin-1 concentration in effluent increased
in a dose-dependent manner with increasing ethanol concentrations. In conclusion, the data suggest that ethanol may stimulate
the release of endothelin from gastric vasculature and may cause gastric ischemia due to vasoconstriction resulting in acute
gastric mucosal injury. 相似文献
75.
Masato Yoneda Emmanuel Thomas Yoshio Sumida Kento Imajo Yuichiro Eguchi Hideyuki Hyogo Hideki Fujii Masafumi Ono Takumi Kawaguchi Eugene R. Schiff 《Hepatology research》2014,44(14):E499-E502
Serum ferritin was recently reported to have low diagnostic accuracy for the detection of advanced fibrosis in patients with non‐alcoholic fatty liver disease (NAFLD). To corroborate these findings, we investigated the diagnostic accuracy of serum ferritin levels for detecting liver fibrosis in NAFLD patients utilizing a large Japanese cohort database. A total 1201 biopsy‐proven NAFLD patients, seen between 2001 and 2013, were enrolled into the Japan Study Group of NAFLD. Analysis was performed on data from this cohort comparing between serum ferritin levels and hepatic histology. Serum ferritin increased with increasing histological grade of steatosis, lobular inflammation and ballooning. Multivariate analyses revealed that sex differences, steatotic grade and fibrotic stage were independently associated with serum ferritin levels (P < 0.0001, <0.0001, 0.0248, respectively). However, statistical analyses performed using serum ferritin levels demonstrated that the area under the receiver–operator curve for detecting fibrosis was not adequate for rigorous prediction. Several factors including sex differences, steatosis and fibrosis were found to correlate with serum ferritin levels. Therefore, serum ferritin may have low diagnostic accuracy for specifically detecting liver fibrosis in NAFLD patients due to the involvement of multiple hepatocellular processes. 相似文献
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79.
Kimio Sugaya Saori Nishijima Katsumi Kadekawa Katsuhiko Noguchi Tomoyuki Ueda Hideyuki Yamamoto 《Lower urinary tract symptoms.》2020,12(1):92-98
The effects of solifenacin and mirabegron on vesical and urethral function were compared in rats with or without spinal cord injury (SCI). Isovolumetric cystometry and urethral pressure recording were initially performed in intact rats. Then, the bladder neck was ligated under urethane anesthesia, after which a catheter was inserted through the bladder dome for isovolumetric cystometry and another catheter was inserted into the urethra to measure urethral pressure. Solifenacin (0.03–3 mg/kg) or mirabegron (0.03–3 mg/kg) was injected intravenously, and bladder and urethral activity were recorded. To create rats with SCI, the spinal cord was transected at the lower thoracic level under isoflurane anesthesia. After 2 weeks, a catheter was inserted through the bladder dome for single cystometry and bladder activity was recorded without anesthesia following intravenous injection of solifenacin or mirabegron. Isovolumetric cystometry revealed a larger decrease in maximum bladder contraction pressure after injection of solifenacin, whereas prolongation of the interval between bladder contractions was greater with mirabegron. In SCI rats, single cystometry showed that solifenacin and mirabegron both increased bladder volume at the first non‐voiding bladder contraction and decreased the maximum bladder contraction pressure. Mirabegron also increased the voided volume and decreased the percentage residual volume without altering bladder capacity. Solifenacin and mirabegron both inhibited bladder contractility, and mirabegron possibly also induced urethral relaxation. Mirabegron may be suitable for patients with overactive bladder and residual urine. 相似文献
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