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排序方式: 共有1035条查询结果,搜索用时 31 毫秒
71.
1 病例报告 男,7岁.因双下肢不等长,右膝及右踝关节骨性肿大就诊.无明显外伤史,亦无红、肿、热、痛病史.查体:发育正常,营养良好.双下肢不等长,左60cm,右64cm,有跛行.右膝及右踝内侧肿大,肤色正常,关节活动无异常.X线:右侧半身诸关节(肩、肘、腕、髋、膝、踝)骨骺及干骺发育均较左侧增大,肢体较长,骨骺出现亦较对侧提早.如右尺骨茎突骨骺较左侧提早出现(图1).右肘关节肱骨小头骨骺较左侧增大(图2).右髋臼发育浅平,边缘毛糙,右股骨头骨骺较左侧明显增大,其距泪滴之距离较左侧大1.0cm,呈… 相似文献
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Basal membrane-depleted scar in lesioned CNS: characteristics and relationships with regenerating axons. 总被引:2,自引:0,他引:2
The lesion scar formed after CNS injury is an impediment to axonal regeneration and leads to growth arrest or misrouting of sprouting axons. Our previous study showed that pharmacological reduction of basal membrane formation within the scar can overcome this scar impermeability [Stichel C. C. et al. (1999) Eur. J. Neurosci. 11, 632-646]. The aim of the present study was to characterize the basal membrane-depleted scar and to analyse its relationships with penetrating axons. The experiments comprised two groups of animals in which the left postcommissural fornix was transected; in addition, one group received a local immediate injection of the collagen IV-reducing agent dipyridyl, while the other group received an injection of phosphate-buffered saline. Immunohistochemical methods were used to characterize scar formation and scar-axon relationships. Animals receiving dipyridyl showed reduction of collagen IV-immunopositive basal membrane in the lesion center, which was accompanied by: (i) a decrease in laminin, as well as chondroitin and heparan sulfate proteoglycan, deposition in the lesion center; (ii) an increase in chondroitin and keratan sulfate proteoglycan expression in the perilesional area; (iii) a typical activation pattern of astrocytes and microglia/macrophages; (iv) axons regenerating through this modified scar were closely associated with various glial cell types and crossed a prominent chondroitin/keratan sulfate proteoglycan matrix. Our results suggest that neither the formation of a reactive astroglial network nor the accumulation of microglia/macrophages or the deposition of chondroitin and keratan sulfate proteoglycans in the perilesional area represent a barrier to regrowing axons. The present approach demonstrates that the lesion-induced basal membrane itself is the primary determinant of scar impermeability. 相似文献
75.
Maja Deković Jessica J. Asscher Jo Hermanns Ellen Reitz Peter Prinzie Alithe L. van den Akker 《Prevention science》2010,11(3):263-274
The present study aimed to (1) determine the long-term effectiveness of Home-Start, a preventive parenting program, and (2)
test the hypothesis that changes in maternal sense of competence mediate the program’s effects. Participants were 124 mothers
(n = 66 intervention, n = 58 comparison). Four assessments took place during a 1-year period. Latent growth modeling showed that Home-Start enhanced
growth in maternal sense of competence and supportive parenting, and led to a decrease in the use of inept discipline. Results
of mediational and cross-lagged analyses were consistent with the hypothesized model: Participation in Home-Start was related
to the changes in maternal sense of competence, which in turn predicted changes in parenting. The results affirm the importance
of directly targeting parental sense of competence in the context of prevention work with parents. 相似文献
76.
Gabriella M van Dijk Cindy Veenhof Francois Schellevis Harry Hulsmans Jan PJ Bakker Henk Arwert Jos HM Dekker Guus J Lankhorst Joost Dekker 《BMC musculoskeletal disorders》2008,9(1):95
Background
This study aims to contribute to the knowledge of the influence of comorbidity in OA. The objectives of the study were (i) to describe the prevalence of comorbidity and (ii) to describe the relationship between comorbidity (morbidity count, severity and the presence of specific diseases) and limitations in activities and pain in elderly patients with knee or hip OA using a comprehensive inventory of comorbidity. 相似文献77.
78.
Norbert Hermanns Marina Mahr Bernd Kulzer Sören E Skovlund Thomas Haak 《Health and quality of life outcomes》2010,8(1):113
Background
The course of barriers towards insulin therapy was analysed in three different groups of type 2 diabetic patients. This observational longitudinal study surveyed a three-month follow-up. 相似文献79.
Rubin JI; Arger PH; Pollack HM; Banner MP; Coleman BG; Mintz MC; VanArsdalen KN 《Radiology》1987,162(1):21
80.