全文获取类型
收费全文 | 86504篇 |
免费 | 41722篇 |
国内免费 | 489篇 |
专业分类
耳鼻咽喉 | 1534篇 |
儿科学 | 4318篇 |
妇产科学 | 804篇 |
基础医学 | 16396篇 |
口腔科学 | 5298篇 |
临床医学 | 13328篇 |
内科学 | 24202篇 |
皮肤病学 | 7669篇 |
神经病学 | 13581篇 |
特种医学 | 2445篇 |
外国民族医学 | 3篇 |
外科学 | 14859篇 |
综合类 | 1764篇 |
现状与发展 | 2篇 |
一般理论 | 23篇 |
预防医学 | 5059篇 |
眼科学 | 1500篇 |
药学 | 6632篇 |
10篇 | |
中国医学 | 1469篇 |
肿瘤学 | 7819篇 |
出版年
2024年 | 35篇 |
2023年 | 174篇 |
2022年 | 384篇 |
2021年 | 1711篇 |
2020年 | 5369篇 |
2019年 | 11073篇 |
2018年 | 10317篇 |
2017年 | 11710篇 |
2016年 | 12323篇 |
2015年 | 12275篇 |
2014年 | 12272篇 |
2013年 | 12794篇 |
2012年 | 4796篇 |
2011年 | 4763篇 |
2010年 | 9433篇 |
2009年 | 5719篇 |
2008年 | 2592篇 |
2007年 | 1439篇 |
2006年 | 1426篇 |
2005年 | 1146篇 |
2004年 | 1037篇 |
2003年 | 1064篇 |
2002年 | 1095篇 |
2001年 | 1015篇 |
2000年 | 898篇 |
1999年 | 431篇 |
1998年 | 98篇 |
1997年 | 80篇 |
1996年 | 61篇 |
1995年 | 66篇 |
1994年 | 61篇 |
1993年 | 53篇 |
1992年 | 121篇 |
1991年 | 102篇 |
1990年 | 92篇 |
1989年 | 83篇 |
1988年 | 82篇 |
1987年 | 82篇 |
1986年 | 71篇 |
1985年 | 57篇 |
1984年 | 37篇 |
1983年 | 33篇 |
1982年 | 30篇 |
1981年 | 24篇 |
1979年 | 23篇 |
1978年 | 17篇 |
1977年 | 15篇 |
1976年 | 26篇 |
1974年 | 12篇 |
1972年 | 12篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
71.
Mark S. Wallace Steven G. Charapata Robert Fisher Michael Byas‐Smith Peter S. Staats Martha Mayo Dawn McGuire David Ellis 《Neuromodulation》2006,9(2):75-86
Objective. The safety and efficacy of intrathecal (IT) ziconotide was studied in a randomized, double‐blind, placebo‐controlled trial. Materials and Methods. Patients (169 ziconotide, 86 placebo) with severe chronic nonmalignant pain unresponsive to conventional therapy and a visual analog scale of pain intensity (VASPI score) ≥ 50 mm were treated over a 6‐day period in an inpatient hospital setting. Initial starting dose was 0.4 µg/hour and was titrated to analgesia or intolerance (maximum dose 7.0 µg/hour). The starting and maximum doses were reduced to 0.1 µg/hour and 2.4 µg/hour, respectively, due to adverse events (AEs). Results. The mean percent reduction in VASPI score from baseline was 31.2% and 6.0% for ziconotide‐ and placebo‐treated patients, respectively (p ≤ 0.001). During the initial titration phase, a significantly greater percentage of patients in the ziconotide group compared to the placebo group reported AEs, including abnormal gait, amblyopia, dizziness, nausea, nystagmus, pain, urinary retention, and vomiting. Conclusion. Ziconotide provided significant analgesia in patients for whom conventional therapy failed. However, there was a considerable incidence of ziconotide‐associated AEs due to the rapid titration and high doses administered. 相似文献
72.
Vincent Chung Liang Liu Zhaoxiang Bian Zhongzhen Zhao Wai Leuk Fong Wan Fung Kum Jing Gao Min Li 《Movement disorders》2006,21(10):1709-1715
The objective of this study is to assess the efficacy and safety of herbal medicines (HMs), as a monotherapy or adjunct therapy, compared to placebo or conventional approaches in the treatment of idiopathic Parkinson's disease (PD). We conducted a systematic review of randomized controlled trials from both conventional and alternative medicine sources. Outcome measures were overall improvement, quality of life, reduction of levodopa dose, and adverse events. Nine studies were included, each testing a different HM. Six of the trials had limited internal validity due to major flaws in design, including the lack of proper randomization; insufficient blinding; unclear inclusive criteria in terms of diagnostic criteria, baseline staging, and duration of disease; lack of proper sample size calculation; and insufficient data analysis. Imbalances in gender and ethnicity among the patients in the included trials were observed. No major adverse events emerged, and no specific pattern was detected from the trials describing such data. In addition to major methodological defects, heterogeneity in (1) HM tested, (2) control treatment, and (3) outcome measure hindered in-depth data analysis and synthesis. Current evidence is insufficient to evaluate the efficacy and safety of various HMs. Further studies with improved trial design and reporting, with assessment on cost-effectiveness, quality of life, and qualitative data are warranted. 相似文献
73.
74.
Abstract: Background: Identification of risk drinking in expectant fathers may be helpful as an important part of efforts to minimize maternal alcohol use, and as an opportunity to inform them about a problematic practice during a critical developmental stage for the couple. The purpose of this study was to evaluate the T‐ACE screening questionnaire, which asks about t olerance to alcohol, being a nnoyed by other's comments about drinking, attempts to c ut down, and having a drink first thing in the morning (“ e ye‐opener”), in the male partners of pregnant women who themselves were T‐ACE positive. Methods: Two hundred fifty‐four male partners were asked to complete the T‐ACE embedded in a health survey, the Alcohol Use Disorders Identification Test (AUDIT), and other questions about their alcohol use in the past 30 days when their pregnant partners had a median gestation of 11.5 weeks (T1). After delivery, male partners again completed the T‐ACE and quantity‐frequency questions (T2). The predictive ability of the T‐ACE and AUDIT was compared, using risk drinking (>4 drinks/day or >14 drinks/week) as the criterion standard. Results: A substantial minority of male partners had risk drinking, 31 percent at T1 and 25 percent at T2. Although the AUDIT was better than the T‐ACE as an independent predictor of risk drinking, the latter was most accurate when the tolerance threshold exceeded 2 drinks, the same established for pregnant women. The sensitivity (T1 = 84.6%, T2 = 82.8%) and specificity (T1 = 43.8%, T2 = 51.1%) of the T‐ACE at this threshold compared favorably with those of the AUDIT at the standard cut point of 8. Conclusions: The T‐ACE may be a practical way for clinicians to identify risk drinking in both pregnant women and expectant fathers. (BIRTH 33:2 June 2006) 相似文献
75.
76.
Dry skin (xerosis) is a common dermatosis affecting people of varying skin types and ages and various areas of the body. It is associated with both skin thickening and skin thinning and is triggered by both exogenous (e.g. climate, environment, lifestyle) and endogenous (e.g. medication, hormone fluctuations, organ diseases) factors. Skin requires a water content of 10–15% to remain supple and intact. This water is either ‘static’ (i.e. bound) or ‘dynamic’. The predominance of hydrophobic substances in intercellular constituents is a means of regulating the humidity of the skin. Emollients, highly effective treatment adjuncts in the management of all dry skin disorders, help to restore damaged intercorneocyte lipid structures and increase the water content of the skin, helping to reduce scaling and improving its barrier function. 相似文献
77.
78.
79.